Antimicrobial resistance: Prevalence, economic burden, mechanisms of resistance and strategies to overcome

Pulingam, Thiruchelvi; Parumasivam, Thaigarajan; Gazzali, Amirah Mohd; Sulaiman, A. Mohd; Chee, Jiun Yee; Lakshmanan, Manoj; Chin, Chai Fung; Sudesh, Kumar

doi:10.1016/j.ejps.2021.106103

Cited by 234 publications

(190 citation statements)

References 93 publications

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“…Sporadic infection cases by similar strains have been identified in our hospital and seem to be increasing. As the advent and dissemination of the multidrug-resistant and highly virulent KP raises an alert, against the backdrop of population ageing and the rising prevalence of chronic conditions such as diabetes, 44 surveillance at epidemiological and molecular levels is paramount to avoid an endemic outbreak.…”

Section: Discussionmentioning

confidence: 99%

Report of a Fatal Purulent Pericarditis Case Caused by ST11-K64 Carbapenem-Resistant Hypervirulent Klebsiella pneumoniae

Liang¹,

Cao²,

Fei³

et al. 2022

IDR

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The report describes a 44-year-old female patient who died of the rare acute purulent pericarditis caused by Klebsiella pneumoniae (KP). The genomic analysis revealed an extensively drug-resistant ST11-K64 KP strain from five isolates (blood cultures, urine, ascites, pericardial effusion, and sputum). Several high virulence (hv) and carbapenem-resistant (CR) genes were identified in the pericardial effuse isolate. The isolates showed low resistance to healthy human serum. This study highlights the potential lethality of CR-hvKP infections in patients suffering from underlying comorbidities such as diabetes mellitus and chronic ailments.

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Section: Discussionmentioning

confidence: 99%

Report of a Fatal Purulent Pericarditis Case Caused by ST11-K64 Carbapenem-Resistant Hypervirulent Klebsiella pneumoniae

Liang¹,

Cao²,

Fei³

et al. 2022

IDR

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“…Antimicrobial resistance is a current public health major threat and World Health Organization (WHO) foresees that, by 2050, 10 million deaths will occur, due to the constant rise of multidrug resistant pathogens, especially in clinical settings [1] . Among them, Klebsiella pneumoniae possesses an extremely developed plastic capability of acquiring resistance to many antibiotics, even to those considered last resort, such as carbapenems [2] .…”

Section: Introductionmentioning

confidence: 99%

Computational design and characterization of a multiepitope vaccine against carbapenemase-producing Klebsiella pneumoniae strains, derived from antigens identified through reverse vaccinology

Cuscino

Fatima²,

Pilato³

et al. 2022

Computational and Structural Biotechnology Journal

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“…The various mechanisms by which bacteria can become resistant to an antimicrobial agent due to the diverse resistance genes possessed by different microbial species are being elucidated [24,66]. Antibiotic therapy boosts the emergence of MDR strains through selection pressure and the transfer of genetic resistance elements.…”

Section: Antibiotic Resistance Trendsmentioning

confidence: 99%

A Systematic Review of Antibiotic Resistance Trends and Treatment Options for Hospital-Acquired Multidrug-Resistant Infections

Agyeman¹,

Bisht²,

Gopinath³

et al. 2022

Cureus

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Antimicrobial resistance is a major public health challenge described by the World Health Organization as one of the top 10 public health challenges worldwide. Drug-resistant microbes contribute significantly to morbidity and mortality in the hospital, especially in the critical care unit. The primary etiology of increasing antibiotic resistance is inappropriate and excessive use of antibiotics. The alarming rise of drugresistant microbes worldwide threatens to erode our ability to treat infections with our current armamentarium of antibiotics.Unfortunately, the pace of development of new antibiotics by the pharmaceutical industry has not kept up with rising resistance to expand our options to treat microbial infections. The costs of antibiotic resistance include death and disability, extended hospital stays due to prolonged sickness, need for expensive therapies, rising healthcare expenditure, reduced productivity from time out of the workforce, and rising penury. This review sums up the common mechanisms, trends, and treatment options for hospital-acquired multidrug-resistant microbes.

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Antimicrobial resistance: Prevalence, economic burden, mechanisms of resistance and strategies to overcome

Cited by 234 publications

References 93 publications

Report of a Fatal Purulent Pericarditis Case Caused by ST11-K64 Carbapenem-Resistant Hypervirulent Klebsiella pneumoniae

Report of a Fatal Purulent Pericarditis Case Caused by ST11-K64 Carbapenem-Resistant Hypervirulent Klebsiella pneumoniae

Computational design and characterization of a multiepitope vaccine against carbapenemase-producing Klebsiella pneumoniae strains, derived from antigens identified through reverse vaccinology

A Systematic Review of Antibiotic Resistance Trends and Treatment Options for Hospital-Acquired Multidrug-Resistant Infections

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