Antimicrobial resistance plasmid reservoir in food and food-producing animals

Madec, Jean‐Yves; Haenni, Marisa

doi:10.1016/j.plasmid.2018.09.001

Cited by 74 publications

(69 citation statements)

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“…1,2,4 The absence of carbapenem use in the veterinarian setting has not prevented the appearance of CRE and CPE in animals. 3 Studies have reported CRE emergence, 5,11,[14][15][16] and underlined the risk of their transmission from animals to humans through foodproducing animals. 3,5,11 In Algeria, the large-scale spread of CPE in human, livestock, and food (fresh vegetables and foodproducing animals) suggests an endemic situation.…”

Section: Discussionmentioning

confidence: 99%

“…Carbapenems are not approved for veterinary use, 2 however, resistance to these antimicrobial agents has emerged in animals in recent years because of successful transmission of Enterobacteriaceae clonal groups and frequent horizontal gene transfer of carbapenemase-expressing plasmids among Gram-negative bacilli. 3,5 Public health officials sounded the alarm when a carbapenemase-producing Enterobacteriaceae (CPE) was isolated for the first time in German swine farms in 2012 6 and carbapenemase-producing Acinetobacter spp. isolates from livestock (dairy farm) in France in 2010.…”

Section: Introductionmentioning

confidence: 99%

“…8 Following this report, several worldwide investigations have reported CPE in food, livestock, companion animals, and wildlife. 3,5 Altogether, these observations led to the One Health initiative, a movement to forge a multidisciplinary network between physicians, veterinarians, and other scientific health and environment-related disciplines (www.onehealthglobal.net). In Algeria, the presence of CPE in nonhuman samples has been extensively reported.…”

Section: Introductionmentioning

confidence: 99%

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Spread of OXA-48 and NDM-1-Producing Klebsiella pneumoniae ST48 and ST101 in Chicken Meat in Western Algeria

Chaalal

Touati

Bakour

et al. 2021

Microbial Drug Resistance

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We investigated the prevalence of carbapenemase-producing Enterobacteriaceae (CPE) in chicken meat in Western Algeria in 2017. Results: From February to July 2017, samples of chicken meat from three poultry farms in Western Algeria were screened for the presence of CPE. Strains were characterized with regard to antibiotic resistance, blactamase content, Plasmid-mediated quinolone resistance, sulfonamide resistance genes, clonality (repetitive sequence-based profiles and multilocus sequence typing) and virulence traits. Of 181 samples analyzed, 29 (16.0%) carbapenemase-producing Klebsiella pneumoniae were detected. Twenty-three OXA-48-producers (79.3%) and six (20.7%) New Delhi metallo (NDM)-1-producers were observed. Clonality analysis showed three distinct lineages and clonal expansions of the OXA-48-producing K. pneumoniae ST48 and the NDM-1producing K. pneumoniae ST101. These isolates harbored fimH, ureA, mrkD, entB, uge, and wabG. Neither capsular serotype genes nor hypermucoviscous phenotype were detected. Plasmid analysis confirmed that all these isolates harbored the transferable IncL and IncFIIK plasmids. Conclusions: This study reports the spread of OXA-48 and NDM-1-producing K. pneumoniae ST48 and ST101 in chicken meat in Western Algeria and demonstrates that food represents a reservoir of the carbapenemases encoding genes.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Spread of OXA-48 and NDM-1-Producing Klebsiella pneumoniae ST48 and ST101 in Chicken Meat in Western Algeria

Chaalal

Touati

Bakour

et al. 2021

Microbial Drug Resistance

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“…The mcr gene has been detected in many plasmid types, including IncI2, IncHI2, IncP, IncX4, IncY, IncF, and ColE10-like ones (Madec and Haenni, 2018) from different origins (Sun et al, 2018). Nevertheless, Matamoros et al (2017) and García-Meniño et al (2019) found that the majority of the mcr-carrier plasmids belonged mainly to four plasmid incompatibility groups: IncX4, IncI2, IncHI2, and ColE10-like.…”

Section: Introductionmentioning

confidence: 99%

Whole Genome Sequencing and Characteristics of mcr-1–Harboring Plasmids of Porcine Escherichia coli Isolates Belonging to the High-Risk Clone O25b:H4-ST131 Clade B

et al. 2020

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“…3GC-resistance is increasingly common in E. coli causing infections in humans (6) and is also found in farmed and domestic animals around the world (7). The production of CTX-M (an extended-spectrum β-lactamase) is the most common mechanism of 3GC-resistance in E. coli in humans in the UK; for example, in a recent study of urinary E. coli from humans in South West England, 82.2% of 3GC-resistant isolates carried bla CTX-M (8).…”

Section: Introductionmentioning

confidence: 99%

Reduced antibacterial drug resistance and bla_CTX-M β-lactamase gene carriage in cattle-associated Escherichia coli at low temperatures, at sites dominated by older animals and on pastureland: implications for surveillance

Schubert

Morley

Puddy

et al. 2019

Preprint

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16Little is known about the drivers of critically important antibacterial resistance in 17 species with zoonotic potential present on farms (e.g. CTX-M ꞵ-lactamase-positive 18 Escherichia coli). There is also debate about the influence of farms on the circulation 19 of resistance in local human populations. This was a two-year surveillance study on 20 53 dairy farms. E. coli positive for blaCTX-M were detected in 224/4145 (5.4%) of all 21 samples from faecally-contaminated sites. E. coli positive for blaCTX-M were more 22 prevalent (98/631; 15.5%) in calf samples and less prevalent (12/630; 1.9%) in 23 samples collected from pastureland, including publicly accessible sites. Multilevel, 24 multivariable logistic regression showed antibiotic dry cow therapeutic choice to be 25 associated with risk of blaCTX-M positivity, including use of cefquinome or framycetin; 26 74% of blaCTX-M-positive E. coli were framycetin-resistant. Low temperature was 27 associated with low risk of blaCTX-M positivity. This was additional to the effect of 28 temperature on total E. coli density, a finding with profound implications for 29 surveillance. There was no evidence that study farms had a significant impact on 30 circulating blaCTX-M plasmids in the local human population: across 296 fully 31 sequenced E. coli isolates, two cattle isolates shared blaCTX-M plasmids with eight 32 urinary isolates collected in parallel.33 34 Antimicrobial resistance (AMR) -and particularly antibacterial resistance (ABR) -is a 35 significant global challenge. Many countries are implementing plans to reduce the 36 use of antibacterial drugs (ABs) in food-producing animals. For example, the most 37 recent UK five-year National Action Plan includes a target to reduce AB use (ABU) in 38the treatment of food-producing animals by 25% (1). In Europe, AB sales for food-39 producing animals fell by 20% from 2011 to 2016 (2). In the UK dairy industry, 40 overall ABU dropped from 24 mg/kg in 2015 to 17 mg/kg in 2017 (3, 4). In 2018, 41 additional industry-led policies were enforced in the UK that aim to almost eliminate 42 the use of highest priority critically important antimicrobials (HP-CIAs) such as third-43 and fourth-generation cephalosporins (3GCs and 4GCs) and fluoroquinolones on 44 dairy farms. One reason for reducing ABU in farming is the belief that such 45 measures will reduce the prevalence of ABR bacteria carried by farm animals. 46 However, there is a need for better data on drivers of ABR in farming. More 47 granularity of understanding is required concerning the risks of using individual ABs 48 and other management practices. This is especially important in terms of drivers of 49 HP-CIA resistance. One key focus is on 3GC resistance in Escherichia coli, a 50 species commonly found in animal faeces and considered one of the most significant 51 potential zoonotic threats to humans (5). 523GC-resistance is increasingly common in E. coli causing infections in humans (6) 53 and is also found in farmed and domestic animals around the world (7). The...

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Antimicrobial resistance plasmid reservoir in food and food-producing animals

Cited by 74 publications

References 122 publications

Spread of OXA-48 and NDM-1-Producing Klebsiella pneumoniae ST48 and ST101 in Chicken Meat in Western Algeria

Spread of OXA-48 and NDM-1-Producing Klebsiella pneumoniae ST48 and ST101 in Chicken Meat in Western Algeria

Whole Genome Sequencing and Characteristics of mcr-1–Harboring Plasmids of Porcine Escherichia coli Isolates Belonging to the High-Risk Clone O25b:H4-ST131 Clade B

Reduced antibacterial drug resistance and bla_CTX-M β-lactamase gene carriage in cattle-associated Escherichia coli at low temperatures, at sites dominated by older animals and on pastureland: implications for surveillance

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Antimicrobial resistance plasmid reservoir in food and food-producing animals

Cited by 74 publications

References 122 publications

Spread of OXA-48 and NDM-1-Producing Klebsiella pneumoniae ST48 and ST101 in Chicken Meat in Western Algeria

Spread of OXA-48 and NDM-1-Producing Klebsiella pneumoniae ST48 and ST101 in Chicken Meat in Western Algeria

Whole Genome Sequencing and Characteristics of mcr-1–Harboring Plasmids of Porcine Escherichia coli Isolates Belonging to the High-Risk Clone O25b:H4-ST131 Clade B

Reduced antibacterial drug resistance and blaCTX-M β-lactamase gene carriage in cattle-associated Escherichia coli at low temperatures, at sites dominated by older animals and on pastureland: implications for surveillance

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Reduced antibacterial drug resistance and bla_CTX-M β-lactamase gene carriage in cattle-associated Escherichia coli at low temperatures, at sites dominated by older animals and on pastureland: implications for surveillance