Antimicrobial resistance patterns of bacteria isolated from canine urinary samples submitted to a New Zealand veterinary diagnostic laboratory between 2005–2012

McMeekin, CH; Hill, KE; Gibson, IR; Bridges, James P.; Benschop, Jackie

doi:10.1080/00480169.2016.1259594

Cited by 32 publications

(44 citation statements)

References 15 publications

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“…E. coli was the most frequently isolated uropathogen in this study with a prevalence similar to that reported elsewhere (35%–70%) 3 6 13 15 18 19. The prevalence of Staphylococcus sp.…”

Section: Discussionsupporting

confidence: 88%

Prevalence of bacteria and changes in trends in antimicrobial resistance ofEscherichia coliisolated from positive canine urinary samples from an Australian referral hospital over a 5‐year period (2013–2017)

Roberts¹,

White²,

Lam³

2019

Veterinary Record Open

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Lower urinary tract disease is common in dogs with approximately 14% developing a bacterial lower urinary tract infection (UTI) during their lifetime. Empirical antimicrobials are often prescribed while waiting urine culture and susceptibility results. Regional knowledge of bacterial prevalence and antimicrobial resistance patterns aids veterinarians in antimicrobial choice. This study aimed to identify the prevalence of uropathogens in canine urine tract isolates and to assess for changes in antimicrobial resistance of Escherichia coli (E. coli) over a 5-year study period at a large multidisciplinary private referral hospital in Australia (January 2013–December 2017). The proportion of resistant isolates was compared across 5 years (Fisher’s exact test and Cochran Armitage test for trend) for select antimicrobials towards E. coli. A total of 246 positive urine cultures were included. E. coli was the most prevalent uropathogen at 64%, followed by Proteus sp., Staphylococcus sp. and Enterococcus sp., respectively (9%, 8% and 7%). E. coli was most commonly resistant to amoxicillin at 41%. There was no statistically significant difference, nor trend, in resistance of E. coli isolates towards the selected antimicrobials over the 5 years. Resistance towards trimethoprim–sulfonamide was lower at 15%. This information will aid local veterinarians in selecting empirical antimicrobials pending culture results for the treatment of UTIs in dogs.

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“…E. coli was the most frequently isolated uropathogen in this study with a prevalence similar to that reported elsewhere (35%–70%) 3 6 13 15 18 19. The prevalence of Staphylococcus sp.…”

Section: Discussionsupporting

confidence: 88%

Prevalence of bacteria and changes in trends in antimicrobial resistance ofEscherichia coliisolated from positive canine urinary samples from an Australian referral hospital over a 5‐year period (2013–2017)

Roberts¹,

White²,

Lam³

2019

Veterinary Record Open

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“…Close contact within the home, between partners, parents and children, and between pets and their owners may be a factor in the transmission of the MDR bacteria isolated in this study. In New Zealand, clinical infections with MDR E. coli occur in pets, but at rates that are unknown and assumed to be low [8,49]. Interestingly, isolates of E. coli collected from dog fecal samples in two different households had unique fecal AMR E. coli, all of which were a different ST from the clinical case.…”

Section: Downloaded Frommentioning

confidence: 99%

Carriage of Extended-Spectrum-Beta-Lactamase- and AmpC Beta-Lactamase-Producing Escherichia coli Strains from Humans and Pets in the Same Households

Toombs-Ruane

Benschop

French

et al. 2020

Appl Environ Microbiol

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Extended spectrum beta-lactamase (ESBL)- or AmpC beta-lactamase (ACBL)- producing Escherichia coli are the most common cause of community-acquired multidrug resistant urinary tract infections (UTIs) in New Zealand. The carriage of antimicrobial resistant bacteria has been found in both people and pets from the same household; thus, the home environment may be a place where antimicrobial resistant bacteria are shared between humans and pets. In this study we sought to determine whether household members (pets and people), from households of human index cases with a UTI caused by an ESBL- or ACBL- producing E. coli strain, also carried an ESBL- or ACBL- producing Enterobacteriaceae strain and if so, whether it was a clonal match to the index case clinical strain. Index cases with a community-acquired UTI were recruited based on antimicrobial susceptibility testing of urine isolates. Fecal samples were collected from 18 non-index people and 36 pets across 27 households. Eleven of the 27 households screened had non-index household members (8/18 people and 5/36 animals) positive for ESBL- and/or ACBL- E. coli. Whole-genome sequence analysis of 125 E. coli isolates (including the clinical urine isolate) from these 11 households showed that within seven households the same strain of ESBL-/ACBL- producing E. coli was cultured, from both the index case and another person (5/11 households) or pet dog (2/11 households). These results suggest that transmission within the household may contribute to community spread of ESBL- or ACBL- producing E. coli. IMPORTANCE Enterobacteriaceae that produce extended-spectrum beta-lactamase (ESBL) and AmpC beta-lactamases (ACBL) are important pathogens and can cause community-acquired illnesses such as urinary tract infections (UTIs). Fecal carriage of these resistant bacteria by companion animals may pose a risk for transmission to humans. Our work evaluated the sharing of ESBL- and ACBL- producing E. coli between humans and companion animals. We found that in some households, dogs carried the same strain of ESBL producing E. coli as the household member with a UTI. This suggests that transmission events between humans and animals (or vice versa) are likely to be occurring within the home environment and therefore the community as a whole. This is significant from a health perspective when considering measures to minimize community transmission and highlights that in order to manage community spread, we need to consider interventions at the household level.

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“…Clavulansäure fördert die Selektion von so genannten pAmpC-Resistenzen und Keime mit diesem Resistenzgen sind gegen Cephalosporine der 1. bis 3. Generation unempfindlich (Karkaba et al, 2017;McMeekin et al, 2017 (Sigel et al, 1981b). gestörtem Allgemeinbefinden mit Zeichen einer Sepsis und/oder SIRS (systemic inflammatory response syndrome) indiziert ist.…”

Section: Therapie Von Harnwegsinfektionenunclassified

AntibioticScout.ch: A decision supporting tool for antimicrobial stewardship: application to companion animal medicine

Ruth

Demuth

Müntener

et al. 2017

SAT

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Bacterial resistances to antimicrobial drugs pose serious public health challenges. The observed increase of resistances is attributed to the uncontrolled, massive and often unnecessary administration of antibiotics both in human and veterinary medicine. To support the responsible use of antimicrobials in animals and help veterinarians selecting the most suitable antimicrobial drugs, we developed the AntibioticScout.ch as a comprehensive decision supporting tool providing online access to the current knowledge of rational antibiotic prescription practices. User-friendly search functions allow for the fast and efficient retrieval of information that is structured in this database by animal species, organ systems and therapeutic indications. In addition, an online form allows to report treatment failures in order to identify problematic cases as well as ensuing risks and take appropriate mitigation measures. The present report describes the workflow of this decision support system applied to the prudent use of antimicrobials in companion animal medicine.

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Antimicrobial resistance patterns of bacteria isolated from canine urinary samples submitted to a New Zealand veterinary diagnostic laboratory between 2005–2012

Cited by 32 publications

References 15 publications

Prevalence of bacteria and changes in trends in antimicrobial resistance ofEscherichia coliisolated from positive canine urinary samples from an Australian referral hospital over a 5‐year period (2013–2017)

Prevalence of bacteria and changes in trends in antimicrobial resistance ofEscherichia coliisolated from positive canine urinary samples from an Australian referral hospital over a 5‐year period (2013–2017)

Carriage of Extended-Spectrum-Beta-Lactamase- and AmpC Beta-Lactamase-Producing Escherichia coli Strains from Humans and Pets in the Same Households

AntibioticScout.ch: A decision supporting tool for antimicrobial stewardship: application to companion animal medicine

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