Antimicrobial Resistance of
            <i>Neisseria gonorrhoeae</i>
            and High Prevalence of Ciprofloxacin-Resistant Isolates in Japan, 1993 to 1998

Tanaka, Masatoshi; Nakayama, Hiroshi; Haraoka, Masashi; Saika, Takeshi; Kobayashi, Ichiro; Naito, Seiji

doi:10.1128/jcm.38.2.521-525.2000

Cited by 131 publications

(46 citation statements)

References 37 publications

(36 reference statements)

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“…This is similar to the mutational sites in QRDR ( grlA and gyrA ) reported by Descloux et al. , 14 and the results from previous studies 40–42 . However, the difference in the MICs between the individual highly resistant strains might be caused by the degree of activation of efflux pumps.…”

Section: Discussionsupporting

confidence: 89%

Antimicrobial resistance of Staphylococcus pseudintermedius isolates from healthy dogs and dogs affected with pyoderma in Japan

Onuma

Tanabe

Sato

2011

Veterinary Dermatology

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Staphylococcus pseudintermedius strains were isolated from healthy dogs and dogs with pyoderma in 2000-2002 and 2009. All the isolates from dogs with pyoderma in 1999-2000 and from healthy dogs in 2000-2002 and 2009 were susceptible to cefalexin and/or other cephalosporins and oxacillin. However, 7.1-12.5 and 11.4% of S. pseudintermedius isolates from dogs with pyoderma in 2009 were resistant to cephalosporins and oxacillin, respectively. All S. pseudintermedius isolates from dogs with pyoderma in 1999-2000 and those from healthy dogs in 2000-2002 were susceptible to fluoroquinolones; however, 50% of the S. pseudintermedius strains isolated from dogs with pyoderma in 2009 and 30% of the S. pseudintermedius strains isolated from healthy dogs in 2009 were resistant to fluoroquinolones. Of the 21 oxacillin-resistant S. pseudintermedius (MRSP) isolates, 11 carried SCCmec type V and 10 carried hybrid SCCmec types II-III. Staphylococcus pseudintermedius strains that were resistant to only one of three fluoroquinolones had a mutation in the quinolone resistance determination region of grlA, whereas S. pseudintermedius strains that were resistant to two or more fluoroquinolones had mutations in the quinolone resistance determination regions of both grlA and gyrA.

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Section: Discussionsupporting

confidence: 89%

Antimicrobial resistance of Staphylococcus pseudintermedius isolates from healthy dogs and dogs affected with pyoderma in Japan

Onuma

Tanabe

Sato

2011

Veterinary Dermatology

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“…In other species also increased efflux out of the cell [76], decreased uptake [77] and protection by competitive binding to target enzymes [78,79] Although these mutations are most common, alterations in other positions have been reported. Three different single mutations in GyrA were reported at Ala67 to Ser, Ala75 to Ser and Ala 84 to Pro, all with wild type ParC and MICs of ciprofloxacin 0.004-0.063 mg/L; however, since strains with alterations at position 91 or 95 were included, it is not possible to state a correlation between resistance and mutations at other positions [96]. An Ala92 to Pro substitution in addition to a Ser91 to Phe substitution was also reported [87].…”

Section: And(37%/7mentioning

confidence: 99%

Verification of clinical samples, positive in AMPLICOR Neisseria gonorrhoeae polymerase chain reaction, by 16S rRNA and gyrA compared with culture

Airell

Lindbäck²,

Ataker

et al. 2005

Int J STD AIDS

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We compared 956 samples for AMPLICOR Neisseria gonorrhoeae polymerase chain reaction (PCR) (Roche) with species verification using the 16S rRNA gene to verification using gyrA gene. Control was the culture method. The gyrA verification uses pyrosequencing of the quinolone resistance-determining region of gyrA. Of 52 samples with optical density >/=0.2 in PCR, 27 were negative in culture, two samples from pharynx were false negative in culture and four samples from pharynx were false positives in verification with 16S rRNA. Twenty-five samples showed growth of gonococci, 18 of the corresponding PCR samples were verified by both methods; three urine samples were positive only in gyrA ; and one pharynx specimen was positive only in 16S rRNA. Three samples were lost. We conclude that AMPLICOR N. gonorrhoeae PCR with verification in gyrA gene can be considered as a diagnostic tool in populations with low prevalence of gonorrhoea and that pharynx specimens should not be analysed by PCR.

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“…GyrA and parcC genes were amplified and sequencing to investigate ciprofloxacin resistance [11]. The gonococcal isolate was PPNG-negative and susceptible to all the antimicrobials tested except to ciprofloxacin (MIC value of 12 mg/L).…”

mentioning

confidence: 99%

Management of a Case of Peritonitis Due to Neisseria gonorrhoeae Infection Following Pelvic Inflammatory Disease (PID)

et al. 2020

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Pelvic inflammatory disease (PID), a serious infection in sexually active women, is one of the reasons for which females seek care in emergency departments and therefore represents an important public health problem. PID is the result of an endocervical infection with different microorganisms, which then ascend to the endometrium and fallopian tubes. Symptoms of PID may be mild and aspecific, making its diagnosis difficult. However, this clinical condition requires effective antibiotic treatment to reduce incidence of complications and late sequelae. We describe here a case of peritonitis as a complication of pelvic inflammatory disease (PID) due to Neisseria gonorrhoeae infection in a 49-year-old woman who presented at the Emergency Department with acute abdominal pain.

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Antimicrobial Resistance of Neisseria gonorrhoeae and High Prevalence of Ciprofloxacin-Resistant Isolates in Japan, 1993 to 1998

Cited by 131 publications

References 37 publications

Antimicrobial resistance of Staphylococcus pseudintermedius isolates from healthy dogs and dogs affected with pyoderma in Japan

Antimicrobial resistance of Staphylococcus pseudintermedius isolates from healthy dogs and dogs affected with pyoderma in Japan

Verification of clinical samples, positive in AMPLICOR Neisseria gonorrhoeae polymerase chain reaction, by 16S rRNA and gyrA compared with culture

Management of a Case of Peritonitis Due to Neisseria gonorrhoeae Infection Following Pelvic Inflammatory Disease (PID)

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