Antimicrobial resistance of germs isolated from invasive infections – Romania 2012

Popescu, Gabriel Adrian; Şerban, Roxana; Iosif, Ionel; Codiţă, Irina; Dorobăţ, O; Tălăpan, Daniela; Buzea, Mariana; Székely, Edit; Dorneanu, Olivia; Bota, Karina; Nica, Manuela; Papageorghe, Raluca; Ghiță, Camelia; Nistor, Irina; Indrared, Marina; Pistol, Adriana; Rafilă, Alexandru

doi:10.1186/1471-2334-13-s1-o16

Cited by 2 publications

(2 citation statements)

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“…Capsaicin in particular has been the focus of recent research as a potential solution against antibiotic resistance [62]. Apart from finding natural alternatives to antibiotics, this is important both for those patients in which some antibiotics may be toxic-typical examples include allergies [63][64][65], liver toxicity [66][67][68][69], and other side effects [70]-and also, and perhaps more significantly, due to the increasing antibiotic resistance [71][72][73][74][75][76][77]. The rapid increase in antibiotic resistance is mainly explained by the overuse of antibiotics [78][79][80] and the high adaptability of bacteria in general, which may survive, depending on the species, even in extreme environments such as hot springs (e.g., [81][82][83]).…”

Section: Antibacterial Properties Of Capsaicinmentioning

confidence: 99%

Antimicrobial Properties of Capsaicin: Available Data and Future Research Perspectives

Periferakis,

Periferakis

et al. 2023

Nutrients

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Capsaicin is a phytochemical derived from plants of the genus Capsicum and subject of intensive phytochemical research due to its numerous physiological and therapeutical effects, including its important antimicrobial properties. Depending on the concentration and the strain of the bacterium, capsaicin can exert either bacteriostatic or even bactericidal effects against a wide range of both Gram-positive and Gram-negative bacteria, while in certain cases it can reduce their pathogenicity by a variety of mechanisms such as mitigating the release of toxins or inhibiting biofilm formation. Likewise, capsaicin has been shown to be effective against fungal pathogens, particularly Candida spp., where it once again interferes with biofilm formation. The parasites Toxoplasma gondi and Trypanosoma cruzi have been found to be susceptible to the action of this compound too while there are also viruses whose invasiveness is significantly dampened by it. Among the most encouraging findings are the prospects for future development, especially using new formulations and drug delivery mechanisms. Finally, the influence of capsaicin in somatostatin and substance P secretion and action, offers an interesting array of possibilities given that these physiologically secreted compounds modulate inflammation and immune response to a significant extent.

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Section: Antibacterial Properties Of Capsaicinmentioning

confidence: 99%

Antimicrobial Properties of Capsaicin: Available Data and Future Research Perspectives

Periferakis,

Periferakis

et al. 2023

Nutrients

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“…The antibacterial properties of the secondary metabolites of plants have been in the foreground of research in the last two decades [ 189 , 190 , 191 , 192 , 193 , 194 , 195 ]. Such research is even more important considering the emergence of numerous resistant [ 196 , 197 ] and multi-drug resistant (MRD) bacteria [ 198 ]. Kaempferol-containing extracts and preparations, as well as pure kaempferol compounds, have been tested as possible antibacterials for quite some time [ 121 , 144 , 199 ].…”

Section: Kaempferol As An Antibacterial Agentmentioning

confidence: 99%

Kaempferol: Antimicrobial Properties, Sources, Clinical, and Traditional Applications

Periferakis

Bădărău

et al. 2022

IJMS

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Flavonoids are a category of plant-derived compounds which exhibit a large number of health-related effects. One of the most well-known and studied flavonoids is kaempferol, which can be found in a wide variety of herbs and plant families. Apart from their anticarcinogenic and anti-inflammatory effects, kaempferol and its associated compounds also exhibit antibacterial, antifungal, and antiprotozoal activities. The development of drugs and treatment schemes based on these compounds is becoming increasingly important in the face of emerging resistance of numerous pathogens as well as complex molecular interactions between various drug therapies. In addition, many of the kaempferol-containing plants are used in traditional systems all over the world for centuries to treat numerous conditions. Due to its variety of sources and associated compounds, some molecular mechanisms of kaempferol antimicrobial activity are well known while others are still under analysis. This paper thoroughly documents the vegetal and food sources of kaempferol as well as the most recent and significant studies regarding its antimicrobial applications.

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Antimicrobial resistance of germs isolated from invasive infections – Romania 2012

Cited by 2 publications

References 0 publications

Antimicrobial Properties of Capsaicin: Available Data and Future Research Perspectives

Antimicrobial Properties of Capsaicin: Available Data and Future Research Perspectives

Kaempferol: Antimicrobial Properties, Sources, Clinical, and Traditional Applications

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