Flavonoids are a category of plant-derived compounds which exhibit a large number of health-related effects. One of the most well-known and studied flavonoids is kaempferol, which can be found in a wide variety of herbs and plant families. Apart from their anticarcinogenic and anti-inflammatory effects, kaempferol and its associated compounds also exhibit antibacterial, antifungal, and antiprotozoal activities. The development of drugs and treatment schemes based on these compounds is becoming increasingly important in the face of emerging resistance of numerous pathogens as well as complex molecular interactions between various drug therapies. In addition, many of the kaempferol-containing plants are used in traditional systems all over the world for centuries to treat numerous conditions. Due to its variety of sources and associated compounds, some molecular mechanisms of kaempferol antimicrobial activity are well known while others are still under analysis. This paper thoroughly documents the vegetal and food sources of kaempferol as well as the most recent and significant studies regarding its antimicrobial applications.

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Antimony has been known and used since ancient times, but its applications have increased significantly during the last two centuries. Aside from its few medical applications, it also has industrial applications, acting as a flame retardant and a catalyst. Geologically, native antimony is rare, and it is mostly found in sulfide ores. The main ore minerals of antimony are antimonite and jamesonite. The extensive mining and use of antimony have led to its introduction into the biosphere, where it can be hazardous, depending on its bioavailability and absorption. Detailed studies exist both from active and abandoned mining sites, and from urban settings, which document the environmental impact of antimony pollution and its impact on human physiology. Despite its evident and pronounced toxicity, it has also been used in some drugs, initially tartar emetics and subsequently antimonials. The latter are used to treat tropical diseases and their therapeutic potential for leishmaniasis means that they will not be soon phased out, despite the fact the antimonial resistance is beginning to be documented. The mechanisms by which antimony is introduced into human cells and subsequently excreted are still the subject of research; their elucidation will enable us to better understand antimony toxicity and, hopefully, to improve the nature and delivery method of antimonial drugs.

Hepatocellular carcinoma (HCC) is the most common primary liver cancer and affects about 8% of cirrhotic patients, with a recurrence rate of over 50%. There are numerous therapies available for the treatment of HCC, depending on cancer staging and condition of the patient. The complexity of the treatment is also justified by the unique pathogenesis of HCC that involves intricate processes such as chronic inflammation, fibrosis, and multiple molecular carcinogenesis events. During the last three decades, multiple in vivo and in vitro experiments have used somatostatin and its analogs (SSAs) to reduce the proliferative and metastatic potential of hepatoma cells by inducing their apoptosis and reducing angiogenesis and the inflammatory component of HCC. Most experiments have proven successful, revealing several different pathways and mechanisms corresponding to the aforementioned functions. Moreover, a correlation between specific effects and expression of somatostatin receptors (SSTRs) was observed in the studied cells. Clinical trials have tested either somatostatin or an analog, alone or in combination with other drugs, to explore the potential effects on HCC patients, in various stages of the disease. While the majority of these clinical trials exhibited minor to moderate success, some other studies were inconclusive or even reported negative outcomes. A complete evaluation of the efficacy of somatostatin and SSAs is still the matter of intense debate, and, if deemed useful, these substances may play a beneficial role in the management of HCC patients.

The focus of this paper is the obsidian quarries of the Pacific coast of pre-Columbian South America, which were exploited by the indigenous populations since ca. 11000 BC. The importance of obsidian in geoarchaeology and palaeoanthropology has already been demonstrated in sites from all around the world. In this paper, the presence of obsidian in correlation to tectonic activity and volcanism of South America is presented, along with the main sources in their regional geological context. Obsidian artefacts were the mainstay of everyday life of indigenous populations and obsidian was also used in manufacturing weapons. Despite advances in metallurgy, which were comparable with those of contemporary European states, obsidian was never supplanted by metal implements and weapons, until the Spanish conquest. Obsidian is as useful today, as it was to these civilisations, albeit in the different role, of discerning interactions between local societies, elucidating aspects of everyday life, and tracing palaeomobility and trade networks. ΠερίληψηΤο θέμα αυτού του άρθρου είναι τα ορυχεία οψιδιανού της ακτής του Ειρηνικού ωκεανού της Προκολομβιανής Αμερικής, των οποίων η εκμετάλλευση είχε αρχίσει από τους ιθαγενείς πληθυσμούς περίπου από το 11000 π.Χ. Η σημασία του οψιδιανού στην γεωαρχαιολογία και στην παλαιοανθρωπολογία έχει ήδη αποδειχθεί σε περιοχές από όλα τα μέρη του κόσμου. Σε αυτό το άρθρο, παρουσιάζεται η ύπαρξη του οψιδιανού, συναρτήσει της τεκτονικής δραστηριότητας και της ηφαιστειότητας της

Medicine is inextricably linked to the notions of progress and innovation which have enabled medical practitioners to diagnose and treat successfully an ever-increasing number of pathologies. The history of innovation in medicine is marked by the development of novel drugs, of anaesthesia, of antisepsis, and of the application of new surgical methods. From the 19th century onwards, which marks the development of modern medical practices, the numerous wars in the West, contributed to the exponential emergence of new medical techniques. Today, not only new methods of therapy and diagnosis are available, but new multidisciplinary medical fields provide new insights and potential for integrative methods of prevention and therapy.

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Gifted children exhibit advanced cognitive abilities, usually beyond their emotional development, which puts them at higher risk of the negative consequences of isolation. This study investigates the effects of distance learning and home confinement on the emotional and social stability, motivation, and attitudes of gifted and non-gifted children in Greece. Our study includes two subsets, from before (September 2017 to March 2020) and after the outbreak of the COVID-19 pandemic (April 2020 to March 2022). The analysis indicated that home confinement and distance learning caused children to create a stronger attachment with their parents, and it increased the involvement of parents in their child’s school experience. Non-gifted children displayed high levels of certain attitudes (perfectionism, desire for acceptance, and condescending behavior) and demonstrated elevated motivation. Gifted children in the pre-COVID-19 period had already displayed increased levels of condescending attitude, which is assumed to be the result of already existing expectations from their parents. The pandemic further increased this attitude, as a result of the higher expectations of their parents. Overall, the study highlighted the importance of children to have more than one support system and the need for them to strengthen their self-image.