Antimicrobial resistance: new insights and therapeutic implications

Sheikh, Bashir Ahmad; Bhat, Basharat Ahmad; Mir, Manzoor Ahmad

doi:10.1007/s00253-022-12175-8

Cited by 14 publications

(8 citation statements)

References 103 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…8-Oxoguanine Detection: 8-Oxoguanine, a DNA damage product induced by 1 O 2 , can generate from the photosensitizer component, [26] porphyrin, in PIL-P and PIL-P-Ce membranes upon light irradiation. To evaluate the photocatalytic activity of PIL-P-based membranes on DNA bases, human genomic DNA was extracted from HEK293T cells.…”

Section: Methodsmentioning

confidence: 99%

Antimicrobial and Antiviral Nanofibers Halt Co‐Infection Spread via Nuclease‐Mimicry and Photocatalysis

Yao,

Luo,

Lin

et al. 2024

Advanced Science

View full text Add to dashboard Cite

The escalating spread of drug‐resistant bacteria and viruses is a grave concern for global health. Nucleic acids dominate the drug‐resistance and transmission of pathogenic microbes. Here, imidazolium‐type poly(ionic liquid)/porphyrin (PIL‐P) based electrospun nanofibrous membrane and its cerium (IV) ion complex (PIL‐P‐Ce) are developed. The obtained PIL‐P‐Ce membrane exhibits high and stable efficiency in eradicating various microorganisms (bacteria, fungi, and viruses) and decomposing microbial antibiotic resistance genes and viral nucleic acids under light. The nuclease‐mimetic and photocatalytic mechanisms of the PIL‐P‐Ce are elucidated. Co‐infection wound models in mice with methicillin‐resistant S. aureus and hepatitis B virus demonstrate that PIL‐P‐Ce integrate the triple effects of cationic polymer, photocatalysis, and nuclease‐mimetic activities. As revealed by proteomic analysis, PIL‐P‐Ce shows minimal phototoxicity to normal tissues. Hence, PIL‐P‐Ce has potential as a “green” wound dressing to curb the spread of drug‐resistant bacteria and viruses in clinical settings.

show abstract

Section: Methodsmentioning

confidence: 99%

Antimicrobial and Antiviral Nanofibers Halt Co‐Infection Spread via Nuclease‐Mimicry and Photocatalysis

Yao,

Luo,

Lin

et al. 2024

Advanced Science

View full text Add to dashboard Cite

show abstract

“…The only treatment therapies available in such circumstances to stop the transmission of the infection and its related problems are frequent isolation of the patient to quarantine and excision of the affected region (69). Even though new antimicrobial agents are constantly established, most of them share the same mode of activity as already existing drugs, making the emergence of tolerance to antimicrobial drugs appear to be unavoidable (70)(71)(72). Such an issue in the pathogenic bacterial organism is made worse by the presence of persister cell subpopulations, which are susceptible to low drug dosages and frequently result in disease resistance (73).…”

Section: Immunotherapies Against Human Bacterial Infectionsmentioning

confidence: 99%

Immunotherapies against human bacterial and fungal infectious diseases: A review

et al. 2023

Self Cite

View full text Add to dashboard Cite

Nations’ ongoing struggles with a number of novel and reemerging infectious diseases, including the ongoing global health issue, the SARS-Co-V2 (severe acute respiratory syndrome coronavirus 2) outbreak, serve as proof that infectious diseases constitute a serious threat to the global public health. Moreover, the fatality rate in humans is rising as a result of the development of severe infectious diseases brought about by multiple drug-tolerant pathogenic microorganisms. The widespread use of traditional antimicrobial drugs, immunosuppressive medications, and other related factors led to the establishment of such drug resistant pathogenic microbial species. To overcome the difficulties commonly encountered by current infectious disease management and control processes, like inadequate effectiveness, toxicities, and the evolution of drug tolerance, new treatment solutions are required. Fortunately, immunotherapies already hold great potential for reducing these restrictions while simultaneously expanding the boundaries of healthcare and medicine, as shown by the latest discoveries and the success of drugs including monoclonal antibodies (MAbs), vaccinations, etc. Immunotherapies comprise methods for treating diseases that specifically target or affect the body’s immune system and such immunological procedures/therapies strengthen the host’s defenses to fight those infections. The immunotherapy-based treatments control the host’s innate and adaptive immune responses, which are effective in treating different pathogenic microbial infections. As a result, diverse immunotherapeutic strategies are being researched more and more as alternative treatments for infectious diseases, leading to substantial improvements in our comprehension of the associations between pathogens and host immune system. In this review we will explore different immunotherapies and their usage for the assistance of a broad spectrum of infectious ailments caused by various human bacterial and fungal pathogenic microbes. We will discuss about the recent developments in the therapeutics against the growing human pathogenic microbial diseases and focus on the present and future of using immunotherapies to overcome these diseases.Graphical AbstractThe graphical abstract shows the therapeutic potential of different types of immunotherapies like vaccines, monoclonal antibodies-based therapies, etc., against different kinds of human Bacterial and Fungal microbial infections.

show abstract

“…These pathogens are also ubiquitous in livestock production systems worldwide, threatening food security and economic development ( 4 , 5 ). Antibiotic and anti-parasitic drug resistance limit effective treatment options for many of these pathogens, and thus, novel solutions are urgently required ( 5 , 6 ).…”

Section: Introductionmentioning

confidence: 99%

Diet composition drives tissue-specific intensity of murine enteric infections

Israelson,

Vedsted-Jakobsen,

Zhu

et al. 2024

mBio

View full text Add to dashboard Cite

Diet composition plays a large role in regulating gut health and enteric infection. In particular, synthetic “Western-style” diets may predispose to disease, while whole-grain diets containing high levels of crude fiber are thought to promote gut health. Here, we show that, in contrast to this paradigm, mice fed with unrefined chow are significantly more susceptible to infection with Trichuris muris , a caecum-dwelling nematode, than mice fed with refined, semi-synthetic diets (SSDs). Moreover, mice fed with SSD supplemented with inulin, a fermentable fiber, developed chronic T. muris burdens, whereas mice fed with SSD efficiently cleared the infection. Diet composition significantly impacted infection-induced changes in the host gut microbiome. Mice infected with the bacterium Citrobacter rodentium were also more susceptible to pathogen colonization when fed with either chow or inulin-enriched SSD. However, transcriptomic analysis of tissues from mice fed with either SSD or inulin-enriched SSD revealed that, in contrast to T. muris , increased C. rodentium infection appeared to be independent of the host immune response. Accordingly, exogenous treatment with interleukin (IL)-25 reduced T. muris burdens in inulin-fed mice, whereas IL-22 treatment was unable to restore resistance to C. rodentium colonization. Diet-mediated effects on pathogen burden were more pronounced for large intestine-dwelling pathogens, as effects on small the intestinal helminth ( Heligmosomoides polygyrus ) were less evident, and protozoan ( Giardia muris ) infection burdens were equivalent in mice fed with chow, inulin-enriched SSD, or SSD, despite higher cyst excretion in chow-fed mice. Collectively, our results point to a tissue- and pathogen-restricted effect of dietary fiber levels on enteric infection intensity. IMPORTANCE Enteric infections induce dysbiosis and inflammation and are a major public health burden. As the gut environment is strongly shaped by diet, the role of different dietary components in promoting resistance to infection is of interest. While diets rich in fiber or whole grain are normally associated with improved gut health, we show here that these components predispose the host to higher levels of pathogen infection. Thus, our results have significance for interpreting how different dietary interventions may impact on gastrointestinal infections. Moreover, our results may shed light on our understanding of how gut flora and mucosal immune function is influenced by the food that we eat.

show abstract

Antimicrobial resistance: new insights and therapeutic implications

Cited by 14 publications

References 103 publications

Antimicrobial and Antiviral Nanofibers Halt Co‐Infection Spread via Nuclease‐Mimicry and Photocatalysis

Antimicrobial and Antiviral Nanofibers Halt Co‐Infection Spread via Nuclease‐Mimicry and Photocatalysis

Immunotherapies against human bacterial and fungal infectious diseases: A review

Diet composition drives tissue-specific intensity of murine enteric infections

Contact Info

Product

Resources

About