Antimicrobial resistance in urinary isolates from inpatients and outpatients at a tertiary care hospital in South-Kivu Province (Democratic Republic of Congo)

Irenge, Léonid M.; Kabego, Landry; Vandenberg, Olivier; Chirimwami, Raphael B; Gala, Jean‐Luc

doi:10.1186/1756-0500-7-374

Cited by 40 publications

(63 citation statements)

References 38 publications

(32 reference statements)

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“…Nitrofurantoin, an oral drug displaying satisfactory activity against uropathogens in South Kivu, [18] was not included in the antimicrobial panel because only parenteral antimicrobials were administered for the treatment of BSIs.…”

Section: Resultsmentioning

confidence: 99%

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Antimicrobial resistance of bacteria isolated from patients with bloodstream infections at a tertiary care hospital in the Democratic Republic of the Congo

et al. 2015

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Corresponding author: L M Irenge (leonid.irenge@uclouvain.be)Background. Bloodstream infection (BSI) is a life-threatening condition that requires rapid antimicrobial treatment. Methods. We determined the prevalence of bacterial isolates associated with BSI at Bukavu General Hospital (BGH), South Kivu Province, Democratic Republic of the Congo, and their patterns of susceptibility to antimicrobial drugs, from February 2013 to January 2014. Results. We cultured 112 clinically relevant isolates from 320 blood cultures. Of these isolates, 104 (92.9%) were Gram-negative bacteria (GNB), with 103 bacilli (92.0%) and one coccus (0.9%). Among GNB, Escherichia coli (51.9%), Klebsiella spp. (20.2%), Enterobacter spp. (6.7%), Shigella spp. (5.8%) and Salmonella spp. (4.8%) were the most frequent agents causing BSIs. Other GNB isolates included Proteus spp., Citrobacter spp. and Pseudomonas aeruginosa (both 2.9%), and Acinetobacter spp. and Neisseria spp. (both 0.9%). High rates of resistance to co-trimoxazole (100%), erythromycin (100%) and ampicillin (66.7 -100%) and moderate to high resistance to ciprofloxacin, ceftazidime, ceftriaxone, cefuroxime and cefepime were observed among GNB. Furthermore, there were high rates of multidrug resistance and of extended-spectrum β-lactamase (ESBL) production phenotype among Enterobacteriaceae. Gram-positive bacteria included three Staphylococcus aureus isolates (2.7%), four oxacillin-resistant coagulase-negative staphylococci (CoNS) isolates (3.6%) and one Streptococcus pneumoniae (0.9%). No oxacillin-resistant S. aureus was isolated. Among clinically relevant staphylococci, susceptibility to co-trimoxazole and ampicillin was low (0 -25%). In addition, 58 contaminant CoNS were isolated from blood cultures, and the calculated ratio of contaminants to pathogens in blood cultures was 1:2. Conclusions. Multidrug-resistant and ESBL-producing GNB are the leading cause of BSI at BGH. Med J 2015;105(9):752-755. S Afr

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Section: Resultsmentioning

confidence: 99%

“…This report follows on from a previous study that documented a high rate of antimicrobial drug-resistant isolates in patients with urinary tract infections at the same healthcare facility. [18] …”

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Antimicrobial resistance of bacteria isolated from patients with bloodstream infections at a tertiary care hospital in the Democratic Republic of the Congo

et al. 2015

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“…Nevertheless, our results are in line with those of Irenge et al, showing 100% prevalence of resistance for ceftriaxone and ceftazidime on ESBL producing Klebsiella spp. strains isolated from urine in Congo [41]. For piperacillin-tazobactam and cefoxitin two β-lactams subject of comparative study on their efficiency on ESBL producing Enterobacteriaceae [42][43][44], we found a prevalence of resistance at 30.91% and 20.93% for Klebsiella pneumoniae and 22.22%, 33.33% for Klebsiella oxytoca respectively.…”

Section: Discussionmentioning

confidence: 93%

“…strains were resistant to ciprofloxacin [41], in Tunisia, 80% (32/40) of Klebsiella spp. strains were resistant to nalidixic acid and 67.5% (27/40) to ciprofloxacin [49].…”

Section: Discussionmentioning

confidence: 99%

Detection of High Prevalence of TEM/SHV/CTX-M Genes in ESBL Producing and Multidrug Resistant Klebsiella Pneumoniae and Klebsiella Oxytoca

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et al. 2016

J Clin Diagn Res

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Background: Klebsiella spp. are Enterobacteriaceae frequently isolated from pathological specimens during urinary tract infections, bloodstream infection, and pus. They are becoming more and more resistant to antibiotics and challenging treatment options. β-lactamases are a great variety of enzymes capable of inducing resistance to β-lactams. The objective of this study was to identify extended-spectrum-β-lactamase (ESBL) genes in Klebsiella spp. strains isolated from various specimens in Lomé, Togo.

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“…[1][2][3] Antibiotics are the cornerstone for treating UTI. Extended-spectrum beta-lactamase (ESBL) producing organisms are increasingly being isolated in cultures from urine samples in Bangladesh.…”

Section: Introductionmentioning

confidence: 99%

Frequency of Extended-Spectrum Beta-Lactamase Producing Organisms Causing Urinary Tract Infection and Their Antibiotic Sensitivity Pattern

et al. 2017

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Abstract Abstract AbstractBackgr Backgr Backgr Backgr Background: ound: ound:ound: ound: The spectrum of bacteria causing urinary tract infection (UTI) and their antibiotic sensitivity pattern is not uniform. Escherichia coli and Klebsiella sp. are two common organisms responsible for UTI through-out the world. The incidence of UTI due to infection with extended-spectrum beta-lactamase (ESBL) producing organisms are increasing. This study was aimed to describe the frequency of ESBL positive organisms causing UTI and their antibiotic sensitivity pattern. Methods:Methods: Methods: Methods: Methods: This cross-sectional study was done in the Department of Internal Medicine, BIRDEM General Hospital from January to April, 2016. Results:Results: Results: Results: Results: Total number of patients was 137 with females predominance (M:F ratio 1 : 3.7). Mean age was 60.3 ±11.7 years. Most patients (131, 95.6%) of the study population were diabetic and glycaemic control was poor (mean HbA1c 9.3 ±2.3) in these subjects. Common symptoms were fever, vomiting, increased urinary frequency, dysuria, suprapubic pain, and loin pain. Neutrophilic leukocytosis was common (94.9%). E. coli (73.7%) was the commonest aetiological agent followed by Klebsiella (8.8%), Enterococcus (4.4%), Citrobacter (3.6%), Staphylococcus aureus (3.6%), Acinetobacter (2.9%), Enterobacter (1.5%), and Pseudomonas (1.5%). Over half of E. coli and of Klebsiella sp. and 100% of Enterobacter organisms were ESBL positive. Imipenem (100%), amikacin, netilmycin,and nitrofurantoin were among the most sensitive antibiotics. Conclusion:Conclusion: Conclusion: Conclusion: Conclusion: More than half (71, 51.82%) of UTI cases were due to ESBL positive organisms. Imipenem, amikacin, netilmycin, and nitrofurantoin remain the drug of choice.

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Antimicrobial resistance in urinary isolates from inpatients and outpatients at a tertiary care hospital in South-Kivu Province (Democratic Republic of Congo)

Cited by 40 publications

References 38 publications

Antimicrobial resistance of bacteria isolated from patients with bloodstream infections at a tertiary care hospital in the Democratic Republic of the Congo

Antimicrobial resistance of bacteria isolated from patients with bloodstream infections at a tertiary care hospital in the Democratic Republic of the Congo

Detection of High Prevalence of TEM/SHV/CTX-M Genes in ESBL Producing and Multidrug Resistant Klebsiella Pneumoniae and Klebsiella Oxytoca

Frequency of Extended-Spectrum Beta-Lactamase Producing Organisms Causing Urinary Tract Infection and Their Antibiotic Sensitivity Pattern

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