Antimicrobial Resistance in Nontyphoidal <i>Salmonella</i> Isolates from Human and Swine Sources in Brazil: A Systematic Review of the Past Three Decades

Rodrigues, Grazielle Lima; Panzenhagen, Pedro; Ferrari, Rafaela Gomes; Paschoalin, Vânia Margaret Flosi; Conté-Júnior, Carlos Adam

doi:10.1089/mdr.2019.0475

Cited by 14 publications

(19 citation statements)

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“…The high frequency of these resistance genes in animal-based food sources can be explained by the routine use of tetracycline and sulfonamide as growth promoters in poultry and swine husbandry in Brazil (Dias de Oliveira et al, 2005;dos Santos et al, 2009). In agreement with our previous study regarding the phenotypical resistance of Salmonella for the last 30 years in Brazil (Rodrigues et al, 2020), both tetracycline and sulfonamide displayed high frequency rates of antimicrobial resistance among Salmonella isolated from swine. These results corroborate with the evidence that the indiscriminate use of antimicrobials in animal husbandry is increasing the antimicrobial resistance in Salmonella (Van Boeckel et al, 2019).…”

Section: Discussionsupporting

confidence: 93%

“…This underreporting situation makes the comprehension of the real level of Salmonella AMR in the country difficult. Several national studies have focused on analyzing the phenotypic antimicrobial resistance in Salmonella ( Dias de Oliveira et al, 2005 ; Campioni et al, 2012 ; Mattiello et al, 2015 ; Zishiri et al, 2016 ; Rodrigues et al, 2020 ), but few recent studies have focused on whole-genome sequence (WGS) analyses of resistant genes ( Almeida et al, 2018 ; Monte et al, 2019a ). Moreover, the current global trend is to use whole-genome sequencing in outbreak detection and surveillance routine of pathogenic bacteria ( Didelot et al, 2012 ; Wilson, 2012 ; Leekitcharoenphon et al, 2014 ).…”

Section: Introductionmentioning

confidence: 99%

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Frequency of Antimicrobial Resistance Genes in Salmonella From Brazil by in silico Whole-Genome Sequencing Analysis: An Overview of the Last Four Decades

et al. 2020

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Rodrigues et al. AMR Salmonella From Brazil frequency rates of antimicrobial resistance genes and predicted resistance phenotypes in the 2000s and the 2010s when compared with the 1980s and 1990s. The results presented herein contributed significantly to the understanding of the strategic use of WGS associated with in silico analysis and the predictions for the determination of AMR in Salmonella from Brazil.

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Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Frequency of Antimicrobial Resistance Genes in Salmonella From Brazil by in silico Whole-Genome Sequencing Analysis: An Overview of the Last Four Decades

et al. 2020

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“…Typhimurium strains displayed the highest frequency of mcr genes. It is well known that S. Typhimurium is the most frequent serovar worldwide (Hendriksen et al 2011;Ferrari et al 2019). This endemic characteristic increases the chance that this serovar has suffered higher selective pressure from the intense and uncontrolled use of colistin over the last years in livestock, in which more S. Typhimurium strains carrying the mcr gene than the other serovars were detected.…”

Section: Accepted Articlementioning

confidence: 99%

Global distribution of plasmid‐mediated colistin resistance mcr gene in Salmonella : A systematic review

Portes

Rodrigues

Leitão

et al. 2021

J of Applied Microbiology

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This systematic review focuses on obtaining the most relevant information from multiple studies that detected a mobilized colistin resistance mcr gene in Salmonella for a better comprehension of its global distribution. A group of strategic and systematic keywords was combined to retrieve research data on the detection frequency of the mcr gene globally from four database platforms (Google Scholar, Science Direct, PubMed, and Scielo). Forty eight studies attended all the eligibility criteria and were selected. China was the country with the highest frequency of Salmonella strains with the mcr gene, and Europe exhibited a wide diversity of countries with positive mcr strains. Also, animals and humans carried the highest frequency of positive strains for the mcr gene. Salmonella Typhimurium was the most frequent serovar carrying the mcr gene.Apparently, colistin overuse in animal husbandry has increased the selective pressure of antimicrobial resistance, resulting in the emergence of a plasmid-mediated colistin resistance mcr gene in China. The mcr-positive Salmonella strains are recently predominant worldwide, which is probably due to the capacity of this gene to be swiftly horizontally transmissible. The transmission ability of mcr-positive Salmonella strains to humans through the consumption of contaminated animal-based food is a public health concern.

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“…As expected, the prevalence of non- S. Enteritidis isolates from poultry meat refers to the change in the epidemiology of Salmonella in the country [ 37 ]. Serotypes Typhimurium and Heidelberg have been prevalent not only in meat but also among the poultry and porcine production chains [ 15 , 38 , 39 ]. These serotypes are also highlighted for presenting a multidrug resistant profile [ 11 , 39 ]; in our study, the totality of S .…”

Section: Discussionmentioning

confidence: 99%

“…Serotypes Typhimurium and Heidelberg have been prevalent not only in meat but also among the poultry and porcine production chains [ 15 , 38 , 39 ]. These serotypes are also highlighted for presenting a multidrug resistant profile [ 11 , 39 ]; in our study, the totality of S . Typhimurium and S .…”

Section: Discussionmentioning

confidence: 99%

Characterization of Salmonella enterica Contamination in Pork and Poultry Meat from São Paulo/Brazil: Serotypes, Genotypes and Antimicrobial Resistance Profiles

et al. 2022

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Salmonellosis is a zoonosis of major relevance to global public health. Here we present the assessment of Salmonella enterica contamination in pork and poultry meat sold at retail markets in São Paulo, Brazil. A total of 780 meat samples (386 poultry meat and 394 pork samples) were collected from 132 markets. From these, 57 samples (7.3%) were positive for S. enterica isolation, including 32 (8.3%) poultry meat and 25 (6.3%) pork samples. S. enterica isolates were further characterized for serotyping, antimicrobial resistance and genotyping by amplified fragment length polymorphism and pulsed field gel electrophoresis. Antimicrobial resistance analysis demonstrated two main profiles: pork isolates were more resistant to macrolides, β-lactams, tetracycline, phenicols, and fluoroquinolones, and poultry meat isolates presented higher resistance to fluoroquinolones, sulfonamides, tetracycline, and β-lactams. A total of 72.4% of poultry meat isolates were identified as S. Heidelberg, while most of pork isolates were S. Typhimurium (31.7%) and S. Give (16.7%). Genotyping resulted in most clusters consisting exclusively of pork or poultry meat, no cross-contamination was detected, and a tendency to differentiate isolates according to their serotypes and markets of origin. High resistance rates to critically important antimicrobials reinforce the importance of controlling Salmonella contamination in meat production chains.

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Antimicrobial Resistance in Nontyphoidal Salmonella Isolates from Human and Swine Sources in Brazil: A Systematic Review of the Past Three Decades

Cited by 14 publications

References 53 publications

Frequency of Antimicrobial Resistance Genes in Salmonella From Brazil by in silico Whole-Genome Sequencing Analysis: An Overview of the Last Four Decades

Frequency of Antimicrobial Resistance Genes in Salmonella From Brazil by in silico Whole-Genome Sequencing Analysis: An Overview of the Last Four Decades

Global distribution of plasmid‐mediated colistin resistance mcr gene in Salmonella : A systematic review

Characterization of Salmonella enterica Contamination in Pork and Poultry Meat from São Paulo/Brazil: Serotypes, Genotypes and Antimicrobial Resistance Profiles

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