Antimicrobial resistance in <i>Vibrio cholerae</i> O1/O139 clinical isolates: a systematic review and meta-analysis

Liu, Chaoying; Wang, Ye; Azizian, Khalil; Omidi, Nazanin; Kaviar, Vahab Hassan; Kouhsari, Ebrahim; Maleki, Afshin

doi:10.1080/14787210.2022.2098114

Cited by 4 publications

(3 citation statements)

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“…The WPR was calculated as follows: azithromycin had a 1%, erythromycin 36%, ciprofloxacin 3%, cotrimoxazole 79%, doxycycline 7%, and tetracycline had a success rate of 20% WPR. Between the years Frontiers in Pharmacology frontiersin.org 1980 and 2020, there was a growth in drug resistance to cotrimoxazole, ciprofloxacin, and tetracycline (Liu et al, 2022).…”

Section: Discussionmentioning

confidence: 99%

“…According to the O antigen, V. cholera species are divided into 206 serotypes. Although the O1 and O139 serotypes are linked to epidemic cholera and non-agglutinating V. cholera (NOVC), which are negative to the O1 and O139 antigens, they cause infrequent severe illnesses ( Liu et al, 2022 ; Onohuean et al, 2022 ). Seventh cholera pandemics linked to O1 and O139 V. cholera serotypes.…”

Section: Introductionmentioning

confidence: 99%

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Resistance of Vibrio cholera to antibiotics that inhibit cell wall synthesis: A systematic review and meta-analysis

et al. 2023

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Objective: Cholera is a challenging ancient disease caused by Vibrio cholera (V. cholera). Antibiotics that prevent cell wall synthesis are among the first known antibiotic groups. Due to its high consumption, V. cholera has developed resistance to the majority of antibiotics in this class. Resistance to recommended antibiotics for the treatment of V. cholera has also increased. In light of the decrease in consumption of certain antibiotics in this group that inhibit cell wall synthesis and the implementation of new antibiotics, it is necessary to determine the antibiotic resistance pattern of V. cholera and to employ the most effective treatment antibiotic.Method: An comprehensive systematic search for relevant articles was conducted in PubMed, Web of Science, Scopus, and EMBASE through October 2020. Stata version 17.1 utilized the Metaprop package to execute a Freeman-Tukey double arcsine transformation in order to estimate weighted pooled proportions.Results: A total of 131 articles were included in the meta-analysis. Ampicillin was the most investigated antibiotic. The prevalence of antibiotic resistance was in order aztreonam (0%), cefepime (0%), imipenem (0%), meropenem (3%), fosfomycin (4%), ceftazidime (5%), cephalothin (7%), augmentin (8%), cefalexin (8%), ceftriaxone (9%), cefuroxime (9%), cefotaxime (15%), cefixime (37%), amoxicillin (42%), penicillin (44%), ampicillin (48%), cefoxitin (50%), cefamandole (56%), polymyxin-B (77%), carbenicillin (95%) respectively.Discussion: Aztreonam, cefepime, and imipenem are the most efficient V. cholera cell wall synthesis inhibitors. There has been an increase in resistance to antibiotics such as cephalothin, ceftriaxone, amoxicillin, and meropenem. Over the years, resistance to penicillin, ceftazidime, and cefotaxime, has decreased.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Resistance of Vibrio cholera to antibiotics that inhibit cell wall synthesis: A systematic review and meta-analysis

et al. 2023

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“…N16961 is a natural locked LCD mutant of V. cholerae with a non-functional hapR, and thus the role of QS in CBASS activity could not be observed in this study. In response to increased usage of SMX to treat cholera infections, SMX resistance has been observed in 79% of O1/O139 isolates (40). However, such resistance is not due to the loss of CBASS function but rather the acquisition of other resistance mechanisms like the SXT integrative conjugative element (41,42).…”

Section: Discussionmentioning

confidence: 99%

Activation of aVibrio choleraeCBASS anti-phage system by quorum sensing and folate depletion

Severin

Ramliden

Ford

et al. 2023

Preprint

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A major challenge faced by bacteria is infection by bacteriophage (phage). Abortive infection is one strategy for combating phage in which an infected cell kills itself to limit phage replication, thus protecting neighboring kin. One class of abortive infection systems is the cyclic oligonucleotide based anti-phage signaling system (CBASS) which relies on two core enzymatic activities; an oligo-nucleotide cyclase that is activated following phage infection and a cyclic-oligo-nucleotide sensitive effector whose activity kills the infected cell. However, the mechanisms behind the deployment and activation of these lethal CBASS systems prior-to and following infection have largely remained a mystery. While exploring unique genomic features of the current pandemic Vibrio cholerae biotype El Tor for clues underlying its pandemic success we found its CBASS was spuriously activated by the folate biosynthesis inhibitor sulfamethoxazole, but only after the population had reached a high-cell density. This population density dependent activity revealed that transcription of both the oligo-nucleotide cyclase, dncV, and the CBASS phospholipase effector, capV, is enhanced at high-cell density by quorum sensing. Together, these results demonstrate that the V. cholerae CBASS is deployed when the environment is densely populated and activated in response to a perturbation in folate biosynthesis.

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Insight into novel inhibitors fromSterculia urensagainst Cholera via pharmacoinformatics and molecular dynamics simulation approaches

Rahman,

Ahmed,

Alqahtani

et al. 2023

Journal of Biomolecular Structure and Dynamics

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Antimicrobial resistance in Vibrio cholerae O1/O139 clinical isolates: a systematic review and meta-analysis

Cited by 4 publications

References 142 publications

Resistance of Vibrio cholera to antibiotics that inhibit cell wall synthesis: A systematic review and meta-analysis

Resistance of Vibrio cholera to antibiotics that inhibit cell wall synthesis: A systematic review and meta-analysis

Activation of aVibrio choleraeCBASS anti-phage system by quorum sensing and folate depletion

Insight into novel inhibitors fromSterculia urensagainst Cholera via pharmacoinformatics and molecular dynamics simulation approaches

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