Antimicrobial resistance. Characteristic of resistance to antimicrobial preparations of Gram-negative bacteria

Abstract

The scope is the literature review on the resistance of Gramnegative bacteria to antimicrobial preparations is presented. 131 different materials were analyzed, including WHO documents and scientifi c publications. Bacterial resistance remains a significant threat and a leading cause of death worldwide. Resistant bacteria proliferate by natural selection when drug-sensitive ones are removed by antibiotics. These organisms can be spread to all health care facilities as well in community, which requires increased attention to infection control measures and the administration of β-lactamcontaining medicines in an effort to control the selection of other even more harmful pathogens. Several strategies for combating and controlling Gram-negative resistant bacteria have been reported, such as the development of antimicrobial auxiliaries, structural modifi cation of existing antibiotics, research and study of chemical structures with new mechanisms of action. In addition to new therapy, an effective infection control system, along with the prudent use of antimicrobials, is extremely important.