Antimicrobial resistance, carbapenemase production, and genotypes of nosocomial Acinetobacter spp. isolates in Russia: results of multicenter epidemiological study ”MARATHON 2015–2016”

Edelstein, Mikhail V.; Шек, Е А; Сухорукова, М В; Skleenova, E.Yu.; Иванчик, Н В; Shaidullina, Elvira; Mikotina, Anna V.; Kuzmenkov, Alexey Yu.; Дехнич, А В; Kozlov, Roman; Semyonova, N. V.; Слепакова, С А; Shepotajlova, N.V.; Strebkova, V.V.; Рыбина, Н А; Yaranceva, N.Z.; Perevalova, E.Yu.; Rozanova, S. M.; Nagovicina, S.G.; Moldovanu, M.G.; Nasybullova, Z.Z.; Архипенко, М. В.; Shakhmuradyan, R.M.; Nizhegorodceva, I.A.; Varibrus, E.V.; Александрова, И. А.; Lazareva, Anna; Kryzhanovskaya, O.A.; Маркелова, Н. Н.; Chernyavskaya, Yu.L.; Лебедева, Е. В.; Kirillova, G.Sh.; Bekker, G.G.; Попова, Л.Д.; Елохина, Е В; Smol’kova, Yu.E.; Zinovev, Dmitriy; Ityaeva, L.N.; Blinova, G.Yu.; Зубарева, Н А; Vityazeva, V.P.; Plaksina, M.G.; Kucevalova, O.Yu.; Panova, N.I.; Суборова, Т Н; Полухина, О. В.; Voroshilova, T. M.; Churikova, E.M.; Москвитина, Е Н; Кречикова, О И; Petrova, T. A.; Mart’yanova, N.M.; Khokhlova, K.O.; Gudkova, L. V.; Bykonya, S.A.; Khokhlyavina, R.M.; Шпилькина, Л В; Бурасова, Е Г; Khrebtovskaya, V.A; Molchanova, I. V.; Zvonaryova, O.V.; Корнилова, П А; Kryanga, V.G.; Portnyagina, U.S.; Шамаева, С. Х.

doi:10.36488/cmac.2019.2.171-180

Cited by 18 publications

(19 citation statements)

References 4 publications

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“…Even though carbapenems remain active against the majority of nosocomial enterobacteria strains (89.5%-90%), the increase in the proportion of isolates resistant to drugs of this group due to the production of carbapenemases (14.4%) is alarming. An increase in resistance to carbapenems was also noted among nosocomial isolates of P. aeruginosa (67.5% for imipenem and 55.5% for meropenem) [4] and A. baumannii (77.4% and 77.1% respectively) [5].…”

Section: Introductionmentioning

confidence: 86%

“…Antimicrobial resistance is one of the key issues limiting the successful treatment of infectious diseases and associated with adverse medical, social and economic consequences on a global scale [1,2]. In recent decades a significant increase in the prevalence of multiresistant microorganisms, primarily Enterobacterales producing extended-spectrum beta-lactamases (ESBLs), carbapenem-resistant strains of Pseudomonas aeruginosa and Acinetobacter baumanii and methicillin-resistant strains of Staphylococcus aureus has been observed in Russian hospitals [3][4][5][6].…”

Section: Introductionmentioning

confidence: 99%

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Longitudinal Point Prevalence Survey of Antimicrobial Consumption in Russian Hospitals: Results of the Global-PPS Project

et al. 2020

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Antimicrobial resistance is one of the key issues limiting the successful treatment of infectious diseases and associated with adverse medical, social and economic consequences on a global scale. The present study aims to evaluate antimicrobials prescribing patterns and assess progress in quality indicators in Russian multidisciplinary hospitals using three repetitive point prevalence studies (PPSs) over 4 years (Global-PPS 2015, 2017 and 2018). Out of 13,595 patients from 21 hospitals surveyed over the three time points, 3542 (26.14%) received antimicrobials, predominantly third-generation cephalosporins (44.7% in 2015, 34.1% in 2017 and 41.8% in 2018). Compliance with the hospital antibiotic guidelines was 74.8%, 66.8% and 74.3%, respectively. Indication for treatment was recorded in 72.6%, 84.1% and 82.6%, while stop/review date was documented only in 40.5%, 46.5% and 61.1% of cases. Perioperative antibiotic prophylaxis exceeded 1 day in 92%, 84% and 81% of cases. Targeted therapy rate at all time points did not exceed 15.1%, treatment based on the biomarkers rate—19.9%. For the part of PPS-2017 and 2018 analyzed in dynamics, no prominent trends were noted. The results of the project provide the basis for the development of appropriate antimicrobial stewardship programs tailored according to local practices for each hospital in the project.

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Section: Introductionmentioning

confidence: 86%

Section: Introductionmentioning

confidence: 99%

Longitudinal Point Prevalence Survey of Antimicrobial Consumption in Russian Hospitals: Results of the Global-PPS Project

et al. 2020

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“…Actually, number of isolates harboring carbapenemase genes was higher than carbapenem resistant isolates: eight isolates were susceptible to imipenem and meropenem despite the presence of carbapenemase genes. The OXA-23 carbapenemases are major mechanism of resistance A. baumannii to carbapenems in the Central Asia and early the spreading of OXA-23 produced hospitals acquired strains of A. baumannii was described in Russia [ 8 ] and South-East Asia countries [ 17 ]. The results of assessing the sensitivity of A. baumannii isolates carrying the genes of acquired OXA-carbapenemases are presented in Table 2 .…”

Section: Resultsmentioning

confidence: 99%

“…In alignment, the CHINET surveillance system in China from 2004 to 2015 the level of carbapenem resistant A. baumannii increased from 31 to 66.7% [ 7 ]. Russian multicenter surveillance study shown the comparable data when carbapenem resistant A. baumannii were detected in 77% [ 8 ]. According to multicenter study nosocomial infections caused by A. baumannii in Pakistan the rate of carbapenem resistance in 2017 was 89% [ 9 ].…”

Section: Introductionmentioning

confidence: 95%

Antibiotic Resistance and Genotypes of Nosocomial Strains of Acinetobacter baumannii in Kazakhstan

et al. 2021

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The aim of this study was to determine the prevalence of A. baumannii antibiotic-resistant strains in Kazakhstan and to characterize genotypes related to epidemic “high-risk” clones. Two hundred and twenty four A. baumannii isolates from four cities of Kazakhstan in 2011–2019 were studied. Antibiotic susceptibility testing was performed by using broth microdilutions method according to EUCAST (v 11.0) recommendations. The presence of blaOXA-23-like, blaOXA-24/40-like, blaOXA-58-like, blaVIM, blaIMP, and blaNDM genes was determined by PCR. Genotyping was performed using high-throughput real-time PCR detection of 21 SNPs at 10 chromosomal loci used in existing MLST schemes. Resistance rates to imipenem, meropenem, amikacin, gentamicin, and ciprofloxacin were 81.3%, 78.6%, 79.9%, 65.2%, and 89.3%, respectively. No colistin resistant isolates were detected. The values of the MIC 50% and the MIC 90% of tigecycline were 0.125 mg/L, only four isolates (1.8%) had the ECOFF value >0.5 mg/L. The presence of acquired carbapenemase genes was found in 82.2% strains, including blaOXA-23-like (78.6%) or blaOXA-58-like (3.6%) genes. The spreading of carbapenem resistant A. baumannii strains in Kazakhstan was associated with epidemic “high-risk” clonal groups, predominantly, CG208(92)OXF/CG2PAS (80.8%) and less often CG231(109)OXF/CG1PAS (1.8%).

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“…c 2011 г. стали регистрироваться первые случаи устойчивости к колистину среди представителей порядка Enterobacterales и у A. baumannii. Между тем, доля нозокомиальных штаммов A. baumannii и P. aeruginosa, устойчивых к полимиксинам, остается в России достаточно низкой [181,182]. С 2010 г. число колистинорезистентных изолятов энтеробактерий в российских стационарах начало прогрессивно увеличиваться и в 2016 г. составляло 6,3%.…”

Section: заключениеunclassified

Review of the international consensus guidelines for the optimal use of the polymyxins

Елисеева

Azyzov

Зубарева

2019

CMAC

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Polymyxins are often the only agents that remain in vitro active against extensively resistant bacterial pathogens. However, the use of polymyxins is compromised by the number of unresolved issues, including the technical aspects of antimicrobial susceptibility testing, pharmacokinetic and pharmacodynamics parameters, optimal dosing regimens, and combined use with other antibiotics. All of the aspects of polymyxin use are discussed in detail in recently published «International consensus guidelines for the optimal use of the polymyxins», that was endorsed by the following professional societies: American College of Clinical Pharmacy (ACCP), European Society of Clinical Microbiology and Infectious Diseases (ESCMID), Infectious Diseases Society of America (IDSA), International Society for Antiinfective Pharmacology (ISAP), Society of Critical Care Medicine (SCCM), and Society of Infectious Diseases Pharmacists (SIDP).

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Antimicrobial resistance, carbapenemase production, and genotypes of nosocomial Acinetobacter spp. isolates in Russia: results of multicenter epidemiological study ”MARATHON 2015–2016”

Cited by 18 publications

References 4 publications

Longitudinal Point Prevalence Survey of Antimicrobial Consumption in Russian Hospitals: Results of the Global-PPS Project

Longitudinal Point Prevalence Survey of Antimicrobial Consumption in Russian Hospitals: Results of the Global-PPS Project

Antibiotic Resistance and Genotypes of Nosocomial Strains of Acinetobacter baumannii in Kazakhstan

Review of the international consensus guidelines for the optimal use of the polymyxins

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