Antimicrobial resistance and a diminishing pool of reserved antibiotics

Abstract

During the second half of the nineteenth century, infectious diseases were a prominent cause of morbidity and mortality. Almost one-third of the infants in the United States and Western Europe were unable to reach their first birthday due to causes attributable to infectious diseases.

Plasma-induced nanostructured metallic silver surfaces: study of bacteriophobic effect to avoid bacterial adhesion on medical devices

“…The bacteria then excrete extracellular matrix creating a consolidated structure that matures as a biofilm [ 6 , 8 , 9 , 10 , 11 ]. Besides these complications, bacteria develop a high resistance to antibiotics and biocides commonly used in hospitals [ 12 , 13 ] and have even incorporated genetic elements of resistance to antibiotics that confer them the ability to survive prolonged treatments [ 14 , 15 ].…”

“…In this scenario, bacterial evolution has cast doubts on the well-established therapies creating a new medical paradigm for a post-antibiotic era [ 12 ], with no antibiotics (or restricted use). The main approaches are focused on the modification of the medical device surface to provide antibacterial properties [ 16 ] through the immobilization of bactericide agents allowing their release.…”

Novel Effective Fluorinated Benzothiophene-Indole Hybrid Antibacterials against S. aureus and MRSA Strains

“…Antibiotic misuse is the most important one. This means the use of antibiotics of last resort in cases where standard antibiotics would have been sufficiently effective, or the use of antibiotics even in instances of viral infections [1, 3,5]. Moreover, the misuse in agriculture to enhance weight and prevent animal infections is still widespread worldwide [1, 3,6,7].…”