Antimicrobial Properties of Plants of Chungtia Village Used Customarily to Treat Skin Related Ailments: From Antimicrobial Screening to Isolation of Active Compounds

Abstract

Prosaposin (PSAP) is both a precursor protein of saposin A-D and a neuroprotective factor. In response to neuropathological disorders such as ischemia, neurotoxins, and nerve transection, PSAP is up-regulated such that both PSAP immunoreactivity and PSAP mRNA levels in neurons increase significantly. PSAP and an 18-mer peptide (PS18) derived from its neurotrophic region were shown to significantly protect damaged neurons. Meyer et al. [1] characterized the PSAP receptors GPR37 and GPR37L1, both of which are involved in neuronal protection, although their expression and their interactions with PSAP have not been fully elucidated (see the review of Smith [2]). However, the increased expression of PSAP and its receptors in damaged neurons and the surrounding glia points to a role for these proteins in protecting damaged cells in the nervous system. This mini-review examines the neuro-and glio-protective functions of PSAP and its receptors, based mainly on data from neuropathological in vivo models. Additional information can be found in the review by Meyer et al. [3].

Identification of Antibacterial Metabolites from Endophytic Fungus Aspergillus fumigatus, Isolated from Albizia lucidior Leaves (Fabaceae), Utilizing Metabolomic and Molecular Docking Techniques

“…Albizia lucidior ( A. lucidior ), commonly known as the Potka siris, is an Asian tree [ 8 ]. Chungtia villagers traditionally used it for the treatment of skin-related ailments [ 11 ]. The antibacterial activity of the ethanolic extract of A. lucidior roots was previously evaluated, showing moderate activity against both susceptible and MRSA S. aureus [ 11 ].…”

“…Chungtia villagers traditionally used it for the treatment of skin-related ailments [ 11 ]. The antibacterial activity of the ethanolic extract of A. lucidior roots was previously evaluated, showing moderate activity against both susceptible and MRSA S. aureus [ 11 ]. However, the chemical potential of endophytic fungi living symbiotically with this plant has not been explored yet.…”