Antimicrobial properties of chitosan solutions, chitosan films and gelatin-chitosan films

Malinowska‐Pańczyk, Edyta; Staroszczyk, Hanna; Gottfried, Karolina; Kołodziejska, Ilona; Wojtasz-Pająk, A.

doi:10.14314/polimery.2015.735

Cited by 29 publications

(19 citation statements)

References 37 publications

(63 reference statements)

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“…After 24 h incubation of films at ambient temperature the number of inoculated bacteria increased from initial 3–4 log CFU/mL to about 7–8 log cycle. Similar dependence was shown by Malinowska‐Pańczyk et al with gelatin films. It implies that using packaging material from biopolymer to moisture food should be modified in order to prevent the growth of microorganisms.…”

Section: Resultssupporting

confidence: 87%

Clay‐filled starch films. Part I: Effect of clay kind and glycerol concentration on functional properties of composites

et al. 2016

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The aim of this work was to improve the mechanical and water barrier properties of composite films prepared from starch and clays, plasticized with glycerol at different concentrations. The effects of hydrophilic Closite Na þ and Nanomer PGV were compared with that exerted by organically modified more hydrophobic Nanofil 2 and NanoBent ZR-1. The antimicrobial activity of composites containing hydrophobic clays was also investigated. The hydrophilic Nanomer PGV at concentrations of 5-10% increased the tensile strength (TS) of unplasticized composites, but starch-Closite Na þ composites were too brittle to measure their mechanical properties. The hydrophobic clays did not improve the mechanical properties of the unplasticized composites. In the presence of glycerol at concentrations of 20-30%, TS of composites containing hydrophilic clays and even hydrophobic NanoBent ZR-1 increased in comparison to plasticized films without clay. None of the clays improved the water barrier properties of the unplasticized composites, while in the plasticized composites all the clays decreased the water vapor permeability to an extent dependent on the kind and concentration of clay and glycerol concentration. Starch-NanoBentZR-1 composite showed very high activity against gram-positive Staphylococcus aureus and Listeria innocua. StarchNanofil 2 composites were characterized by smaller activity. Neither composite showed any antimicrobial activity, or their activity against gram-negative bacteria was low.

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Section: Resultssupporting

confidence: 87%

Clay‐filled starch films. Part I: Effect of clay kind and glycerol concentration on functional properties of composites

et al. 2016

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“…The specific feature of chitosan is its antibacterial and antifungal activity [14]. These properties exhibit acidic chitosan solutions, hydrogel forms, films, and dry sponges [15][16][17]. The antimicrobial activity of chitosan depends on many physicochemical factors: the molecular weight of the polymer, its degree of deacetylation, the pH of the environment, and the changes caused by the modification.…”

Section: Introductionmentioning

confidence: 99%

Obtaining and Characterization of the PLA/Chitosan Foams with Antimicrobial Properties Achieved by the Emulsification Combined with the Dissolution of Chitosan by CO2 Saturation

Mania

Partyka²,

Pilch

et al. 2019

Molecules

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A new method of obtaining functional foam material has been proposed. The materials were created by mixing the poly lactic acid (PLA) solution in chloroform, chitosan (CS) dissolved in water saturated with CO2 and polyethylene glycol (PEG), and freeze-dried for removal of the solvents. The composite foams were characterized for their structural (SEM, FT-IR, density, porosity), thermal (DSC), functional (hardness, elasticity, swelling capacity, solubility), and biological (antimicrobial and cytotoxic) properties. Chitosan in the composites was a component for obtaining their foamed form with 7.4 to 22.7 times lower density compared to the neat PLA and high porosity also confirmed by the SEM. The foams had a hardness in the range of 70–440 kPa. The FT-IR analysis confirmed no new chemical bonds between the sponge ingredients. Other results showed low sorption capacity (2.5–7.2 g/g) and solubility of materials (less than 0.2%). The obtained foams had the lower Tg value and improved ability of crystallization compared to neat PLA. The addition of chitosan provides the bacteriostatic and bactericidal properties against Escherichia coli and Staphylococcus aureus. Biocompatibility studies have shown that the materials obtained are not cytotoxic to the L929 cell line.

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“…The interaction between the amino groups of chitosan with the anionic components of microorganisms (lipopolysaccharides, teichoic acid) is assumed to be the main antimicrobial mechanism. 34 Regarding the efficiency against bacteria, all the samples showed inferior activity against Escherichia coli by comparison with that against Staphylococcus aureus, which was more pronounced.…”

Section: Cytotoxicitymentioning

confidence: 96%

Characterization of Neomycin-Loaded Xanthan-Chitosan Hydrogels for Topical Applications

Merlusca¹,

Ibănescu²,

Tuchiluş³

et al. 2019

Cellulose Chem. Technol.

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Xanthan-chitosan hydrogels are recommended for encapsulation and controlled release of therapeutic agents. Chitosan and neomycin sulphate have been shown to have wound healing properties, when used individually, and a synergetic effect when used together. In this study, drug-loaded xanthan-chitosan hydrogels were prepared with two different neomycin sulphate concentrations, as potential topical formulations. These hydrogels were characterized by rheological studies, thermal analyses, for in vitro drug release diffusion, cytotoxicity and antibacterial activity. The results obtained from dynamic rheological experiments demonstrated that the hydrogels behave as weak gels and that their characteristics are strongly influenced by the concentration, pH and temperature. The results provided by thermal analysis suggested that an interaction occurs between xanthan-chitosan and neomycin sulphate. In vitro studies demonstrated good retardation of drug release from the hydrogels. Moreover, cell viability studies showed that the hydrogels are non-cytotoxic. Furthermore, the prepared formulations revealed effective bacterial inhibition when exposed to cultures of Escherichia coli and Staphylococcus aureus.

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Antimicrobial properties of chitosan solutions, chitosan films and gelatin-chitosan films

Cited by 29 publications

References 37 publications

Clay‐filled starch films. Part I: Effect of clay kind and glycerol concentration on functional properties of composites

Clay‐filled starch films. Part I: Effect of clay kind and glycerol concentration on functional properties of composites

Obtaining and Characterization of the PLA/Chitosan Foams with Antimicrobial Properties Achieved by the Emulsification Combined with the Dissolution of Chitosan by CO2 Saturation

Characterization of Neomycin-Loaded Xanthan-Chitosan Hydrogels for Topical Applications

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