Characterization of Neomycin-Loaded Xanthan-Chitosan Hydrogels for Topical Applications

Abstract

Xanthan-chitosan hydrogels are recommended for encapsulation and controlled release of therapeutic agents. Chitosan and neomycin sulphate have been shown to have wound healing properties, when used individually, and a synergetic effect when used together. In this study, drug-loaded xanthan-chitosan hydrogels were prepared with two different neomycin sulphate concentrations, as potential topical formulations. These hydrogels were characterized by rheological studies, thermal analyses, for in vitro drug release diffusion, cytotoxicity and antibacterial activity. The results obtained from dynamic rheological experiments demonstrated that the hydrogels behave as weak gels and that their characteristics are strongly influenced by the concentration, pH and temperature. The results provided by thermal analysis suggested that an interaction occurs between xanthan-chitosan and neomycin sulphate. In vitro studies demonstrated good retardation of drug release from the hydrogels. Moreover, cell viability studies showed that the hydrogels are non-cytotoxic. Furthermore, the prepared formulations revealed effective bacterial inhibition when exposed to cultures of Escherichia coli and Staphylococcus aureus.

Active Packaging—Poly(Vinyl Alcohol) Films Enriched with Tomato By-Products Extract

“…The films PVA + Ch and PVA + Ch + TBE for the investigated shear rate range presented pseudo-plastic (shear-thinning) behavior, and as can be seen in the figures (Figure 3A-C), for all three temperatures, the viscosity decreased slowly with intensifying shear rate, which is a typical feature of polymer solutions. These pseudo-plastic materials at increasing shear rate have reduced shear viscosity, due to the alignment of the large molecular chains in the course of higher shear rate, which generates lower resistance [61,62]. However, with the increase in temperature, the viscosity presented higher values, and at higher shear rates, the viscosity also decreased exponentially.…”

Evaluation of the Wound Healing Potential of Some Natural Polymers on Three Experimental Models

“…The high values of zero shear viscosity calculated with the Carreau-Yasuda model using the flow curves also emphasized the structural stability of the samples [ 9 , 10 , 11 ].…”

On the Development of Chitosan-Graft-Poly(n-Isopropylacrylamide) by Raft Polymerization Technique

“…Other modified chitosan based hydrogels were also found suitable for topical application, the evidence being the number of studies performed in this field. [17][18][19][20]…”