Antimicrobial potential of Pectis substriata essential oil (Asteraceae) against drug-resistant Staphylococcus strains

Jesus, Genilson S De; Micheletti, Ana Camila; Takahashi, Karen Midori; Matayoshi, Tatiana; Pott, Arnildo; Yoshida, Norimasa

doi:10.1590/0001-3765202020200456

Cited by 6 publications

(2 citation statements)

References 29 publications

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“…Pectis substriata EO exerted a potential activity against resistant staphylococcus strains [64]. The antibiotic-like action of EOs is attributed to the biofilm inhibition [65], membrane disruption and efflux suppression action mechanism [66]. Moreover, inhibition of inflammatory cytokine and suppression of superoxide production were reported as the mode of antimicrobial action of terpinen-4-ol tea tree oil [67].…”

Section: The Effect Of Neg8 On Histopathologymentioning

confidence: 99%

Topical Nano Clove/Thyme Gel against Genetically Identified Clinical Skin Isolates: In Vivo Targeting Behavioral Alteration and IGF-1/pFOXO-1/PPAR γ Cues

et al. 2021

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Antimicrobial resistance is a dramatic global threat; however, the slow progress of new antibiotic development has impeded the identification of viable alternative strategies. Natural antioxidant-based antibacterial approaches may provide potent therapeutic abilities to effectively block resistance microbes’ pathways. While essential oils (EOs) have been reported as antimicrobial agents, its application is still limited ascribed to its low solubility and stability characters; additionally, the related biomolecular mechanisms are not fully understood. Hence, the study aimed to develop a nano-gel natural preparation with multiple molecular mechanisms that could combat bacterial resistance in an acne vulgaris model. A nano-emulgel of thyme/clove EOs (NEG8) was designed, standardized, and its antimicrobial activity was screened in vitro and in vivo against genetically identified skin bacterial clinical isolates (Pseudomonas stutzeri, Enterococcus faecium and Bacillus thuringiensis). As per our findings, NEG8 exhibited bacteriostatic and potent biofilm inhibition activities. An in vivo model was also established using the commercially available therapeutic, adapalene in contra genetically identified microorganism. Improvement in rat behavior was reported for the first time and NEG8 abated the dermal contents/protein expression of IGF-1, TGF-β/collagen, Wnt/β-catenin, JAK2/STAT-3, NE, 5-HT, and the inflammatory markers; p(Ser536) NF-κBp65, TLR-2, and IL-6. Moreover, the level of dopamine, protective anti-inflammatory cytokine, IL-10 and PPAR-γ protein were enhanced, also the skin histological structures were improved. Thus, NEG8 could be a future potential topical clinical alternate to synthetic agents, with dual merit mechanism as bacteriostatic antibiotic action and non-antibiotic microbial pathway inhibitor.

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Section: The Effect Of Neg8 On Histopathologymentioning

confidence: 99%

Topical Nano Clove/Thyme Gel against Genetically Identified Clinical Skin Isolates: In Vivo Targeting Behavioral Alteration and IGF-1/pFOXO-1/PPAR γ Cues

et al. 2021

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“…Numerous studies have also demonstrated the efficacy of EOs from cinnamon ( Cinnamomum zeylanicum ), lemongrass ( Cymbopogon citratus ), tea tree ( Melaleuca alternifolia ), and rosemary ( Rosmarinus officinalis ) as promising antimicrobials [ 12 , 13 , 14 , 15 , 16 ]. Multiple studies have shown synergistic effects between various EOs and antibiotics, potentially providing a possible resolution to the antibiotic resistance issue in the clinical setting [ 1 , 17 , 18 , 19 , 20 ]. EOs have garnered great attention due to their accessibility, biocompatibility, and potential antibacterial capacities without inducing drug resistance [ 21 ].…”

Section: Introductionmentioning

confidence: 99%

Anti- and Pro-Oxidant Properties of Essential Oils against Antimicrobial Resistance

et al. 2022

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The rapid evolution of antimicrobial resistance (AMR) has remained a major public health issue, reducing the efficacy of antibiotics and increasing the difficulty of treating infections. The discovery of novel antimicrobial agents is urgently needed to overcome the challenges created by AMR. Natural products such as plant extracts and essential oils (EOs) have been viewed as potential candidates to combat AMR due to their complex chemistry that carries inherent pro-oxidant and antioxidant properties. EOs and their constituents that hold pro-oxidant properties can induce oxidative stress by producing reactive oxygen species (ROS), leading to biological damage in target cells. In contrast, the antioxidant properties scavenge free radicals through offsetting ROS. Both pro-oxidant and antioxidant activities in EOs represent a promising strategy to tackle AMR. Thus, this review aimed to discuss how pro-oxidants and antioxidants in EOs may contribute to the mitigation of AMR and provided a detailed description of the challenges and limitations of utilizing them as a means to combat AMR.

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Metabolomic profiling and assessment of antimicrobial, antioxidant and genotoxic potential of Unonopsis guatterioides R.E.Fr. (Annonaceae) fruits

Santos

Santana

Micheletti

et al. 2023

Arabian Journal of Chemistry

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Antimicrobial potential of Pectis substriata essential oil (Asteraceae) against drug-resistant Staphylococcus strains

Cited by 6 publications

References 29 publications

Topical Nano Clove/Thyme Gel against Genetically Identified Clinical Skin Isolates: In Vivo Targeting Behavioral Alteration and IGF-1/pFOXO-1/PPAR γ Cues

Topical Nano Clove/Thyme Gel against Genetically Identified Clinical Skin Isolates: In Vivo Targeting Behavioral Alteration and IGF-1/pFOXO-1/PPAR γ Cues

Anti- and Pro-Oxidant Properties of Essential Oils against Antimicrobial Resistance

Metabolomic profiling and assessment of antimicrobial, antioxidant and genotoxic potential of Unonopsis guatterioides R.E.Fr. (Annonaceae) fruits

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