2020
DOI: 10.1128/msphere.00492-20
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Antimicrobial Photodynamic Therapy with Chlorin e6 Is Bactericidal against Biofilms of the Primary Human Otopathogens

Abstract: Moraxella catarrhalis, Streptococcus pneumoniae, and nontypeable Haemophilus influenzae (NTHi) are ubiquitous upper respiratory opportunistic pathogens. Together, these three microbes are the most common causative bacterial agents of pediatric otitis media (OM) and have therefore been characterized as the primary human otopathogens. OM is the most prevalent bacterial infection in children and the primary reason for antibiotic administration in this population. Moreover, biofilm formation has been confirmed as … Show more

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Cited by 28 publications
(26 citation statements)
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“…Previous studies from our lab and others have suggested that this technology could be effective vs. bacteria associated with OM ( Jung et al, 2009 ; Luke-Marshall et al, 2014 , 2020 ; Liu et al, 2020 ). We recently reported aPDT using Ce6 exhibits significant bactericidal activity against monomicrobial planktonic and biofilms of non-typeable H. influenzae, S. pneumoniae and M. catarrhalis ( Luke-Marshall et al, 2020 ). However, it is now well accepted that many cases of recurrent and chronic OM involve multiple bacterial species in complex biofilms.…”
Section: Introductionmentioning
confidence: 78%
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“…Previous studies from our lab and others have suggested that this technology could be effective vs. bacteria associated with OM ( Jung et al, 2009 ; Luke-Marshall et al, 2014 , 2020 ; Liu et al, 2020 ). We recently reported aPDT using Ce6 exhibits significant bactericidal activity against monomicrobial planktonic and biofilms of non-typeable H. influenzae, S. pneumoniae and M. catarrhalis ( Luke-Marshall et al, 2020 ). However, it is now well accepted that many cases of recurrent and chronic OM involve multiple bacterial species in complex biofilms.…”
Section: Introductionmentioning
confidence: 78%
“…Based on our recently published data, we tested the successive dual-treatment approach on polymicrobial otopathogen biofilms under the hypothesis that the first round of treatment weakens the integrity of the biofilm structure so that the second treatment would be more effective at killing the remaining bacteria ( Luke-Marshall et al, 2020 ). Triple species biofilms were treated once or twice with 10 μM Ce6 for 15 min followed by a 15 min LED exposure.…”
Section: Resultsmentioning
confidence: 99%
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