Quantum dot-enabled membrane-tethering and enhanced photoactivation of chlorin-e6

Sangtani, Ajmeeta; Nag, Okhil K.; Oh, Eunkeu; Stewart, Michael H.; Delehanty, James B.

doi:10.1007/s11051-021-05297-z

Cited by 1 publication

(1 citation statement)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[45] In another study, Sangtani et al have designed a QDÀ Ce6 nanocomposites decorated with membrane-tethering peptide, and tested it on mammalian cells. [46] It has been demonstrated that excitation of Ce6 in a FRET configuration results in membrane-localized ROS generation and inhibition of cellular proliferation.…”

Section: Introductionmentioning

confidence: 99%

FRET‐Amplified Singlet Oxygen Generation by Nanocomposites Comprising Ternary AgInS₂/ZnS Quantum Dots and Molecular Photosensitizers

Oskolkova,

Matiushkina,

Borodina

et al. 2024

ChemNanoMat

View full text Add to dashboard Cite

Antibacterial photodynamic therapy (a‐PDT) has emerged as a promising non‐invasive therapeutic modality that utilizes the combination of a photosensitive agent, molecular oxygen, and excitation light to generate reactive oxygen species (ROS), demonstrating remarkable activity against multidrug‐resistant bacterial infections. However, the effective use of conventional photosensitizers is significantly limited by a number of their shortcomings, namely, poor water solubility and low selectivity. Herein, we present a novel biocompatible water‐soluble nanocomposite based on hydrophobic tetraphenylporphyrin (TPP) molecules and hydrophilic ternary AgInS2/ZnS quantum dots incorporated into a chitosan matrix as an improved photosensitizer for a‐PDT. We demonstrated that TPP molecules could be successfully transferred into chitosan solution while remaining primarily in the form of monomers, which are capable of singlet oxygen generation. We performed a detailed analysis of the Förster resonance energy transfer (FRET) between quantum dots and TPP molecules within the nanocomposite and proposed the mechanism of the singlet oxygen efficiency enhancement via FRET.

show abstract

Section: Introductionmentioning

confidence: 99%

FRET‐Amplified Singlet Oxygen Generation by Nanocomposites Comprising Ternary AgInS₂/ZnS Quantum Dots and Molecular Photosensitizers

Oskolkova,

Matiushkina,

Borodina

et al. 2024

ChemNanoMat

View full text Add to dashboard Cite

show abstract

Quantum dot-enabled membrane-tethering and enhanced photoactivation of chlorin-e6

Cited by 1 publication

References 40 publications

FRET‐Amplified Singlet Oxygen Generation by Nanocomposites Comprising Ternary AgInS₂/ZnS Quantum Dots and Molecular Photosensitizers

FRET‐Amplified Singlet Oxygen Generation by Nanocomposites Comprising Ternary AgInS₂/ZnS Quantum Dots and Molecular Photosensitizers

Contact Info

Product

Resources

About

Quantum dot-enabled membrane-tethering and enhanced photoactivation of chlorin-e6

Cited by 1 publication

References 40 publications

FRET‐Amplified Singlet Oxygen Generation by Nanocomposites Comprising Ternary AgInS2/ZnS Quantum Dots and Molecular Photosensitizers

FRET‐Amplified Singlet Oxygen Generation by Nanocomposites Comprising Ternary AgInS2/ZnS Quantum Dots and Molecular Photosensitizers

Contact Info

Product

Resources

About

FRET‐Amplified Singlet Oxygen Generation by Nanocomposites Comprising Ternary AgInS₂/ZnS Quantum Dots and Molecular Photosensitizers

FRET‐Amplified Singlet Oxygen Generation by Nanocomposites Comprising Ternary AgInS₂/ZnS Quantum Dots and Molecular Photosensitizers