Antimicrobial photodynamic therapy mediated by methylene blue in surfactant vehicle as adjuvant to periodontal treatment. Randomized, controlled, double-blind clinical trial

Kassa, Claudio Teruo; Salviatto, Luciana Toledo Costa; Tortamano, Ana Carolina A.C.; Rost-Lima, Ketlyn Sthefany; Damante, Carla Andreotti; Pavani, Christiane; Deana, Alessandro Melo; Kato, Ilka Tiemy; Wainwright, Mark; Prates, Renato Araújo

doi:10.1016/j.pdpdt.2022.103194

Cited by 9 publications

(3 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Numerous studies in the literature have explored the use of photodynamic therapy (PDT) for managing deep pockets in periodontitis [ 35 ]. For instance, a systematic review and meta-analysis (SR–MA) investigating the impact of adjunctive PDT on clinical attachment loss (CAL) in stages II-IV grade C periodontitis was conducted [ 36 ].…”

Section: Discussionmentioning

confidence: 99%

Photodynamic Therapy with Tolonium Chloride and a Diode Laser (635 nm) in the Non-Surgical Management of Periodontitis: A Clinical Study

Mobadder

Namour

Grzech‐Leśniak

2023

JCM

View full text Add to dashboard Cite

This study aimed to evaluate the efficacy of photodynamic therapy (PDT) using tolonium chloride and a 635 nm diode laser as an adjunct to non-surgical periodontitis treatment, specifically scaling and root planing (SRP) alone. A total of 32 patients with a pocket probing depth > 5 mm were included in the study. Among them, 16 patients underwent SRP alone (control group), and the remaining 16 patients received SRP along with PDT (study group). The PDT procedure utilized a 635 nm diode laser (Smart M, Lasotronix, Poland) and tolonium chloride. Clinical periodontal parameters, such as the plaque index (PI), bleeding on probing (BOP), gingival recession (GR), probing pocket depth (PPD), and clinical attachment loss (CAL), were assessed before treatment (T0) and at 3 months after treatment (T3). At T3, both groups demonstrated a significant reduction in the PI, BOP, PD, and CAL compared to T0. The SRP + PDT group displayed a significant reduction in PPD (3.79 mm ± 0.35) compared to the SRP alone group (4.85 mm ± 0.42) at T3. Furthermore, the SRP + PDT group exhibited a significant reduction in CAL (5.01 ± 0.81) compared to the SRP group (5.99 ± 1.08) at T3. Within the study’s limitations, it was concluded that PDT, with tolonium chloride and a 635 nm diode laser, significantly contributed to the non-surgical treatment of periodontitis.

show abstract

Section: Discussionmentioning

confidence: 99%

Photodynamic Therapy with Tolonium Chloride and a Diode Laser (635 nm) in the Non-Surgical Management of Periodontitis: A Clinical Study

Mobadder

Namour

Grzech‐Leśniak

2023

JCM

View full text Add to dashboard Cite

show abstract

“…Laser therapy was administered using two PS solutions. The results of the study indicated that there were no significant differences between the groups in terms of reduction in bacteria levels and testing depths ( 36 ).…”

Section: Non-invasive A-pdt Therapy For the Treatment Of Periodontiti...mentioning

confidence: 99%

Evaluating the potency of laser-activated antimicrobial photodynamic therapy utilizing methylene blue as a treatment approach for chronic periodontitis

Karuppan Perumal,

Rajan Renuka,

Manickam Natarajan

2024

Front. Oral. Health

View full text Add to dashboard Cite

Chronic periodontitis is a ubiquitous inflammatory disease in dental healthcare that is challenging to treat due to its impact on bone and tooth loss. Conventional mechanical debridement has been challenging in eliminating complex subgingival biofilms. Hence, adjunctive approaches like low-level laser antimicrobial photodynamic therapy (A-PDT) utilising methylene blue (MB) have been emerging approaches in recent times. This review evaluates the latest research on the use of MB-mediated A-PDT to decrease microbial count and enhance clinical results in chronic periodontitis. Studies have shown the interaction between laser light and MB generates a phototoxic effect thereby, eliminating pathogenic bacteria within periodontal pockets. Moreover, numerous clinical trials have shown that A-PDT using MB can reduce probing depths, improve clinical attachment levels, and decrease bleeding during probing in comparison to traditional treatment approaches. Notably, A-PDT shows superior antibiotic resistance compared to conventional antibiotic treatments. In conclusion, the A-PDT using MB shows promise as an adjunctive treatment for chronic periodontitis. Additional research is required to standardize treatment protocols and assess long-term outcomes of A-PDT with MB in the treatment of periodontitis.

show abstract

“…At present, the commonly used PSs, including protoporphyrin IX (PpIX), methylene blue (MB), and chlorin e6 (Ce6), have poor water solubility, high toxicity, and poor photostability, , which limit their application in PDT. AuNCs are characterized by low toxicity, high biocompatibility, and biodegradability .…”

Section: Auncs In Pdtmentioning

confidence: 99%

A Review on Gold Nanoclusters for Cancer Phototherapy

Yang,

Guo

et al. 2023

ACS Appl. Bio Mater.

View full text Add to dashboard Cite

Cancer phototherapy, including photodynamic therapy (PDT) and photothermal therapy (PTT), has been extensively studied in recent years because of its noninvasive properties, high efficiency, improved selectivity, and reduced side effects. Gold nanoclusters (AuNCs) have the advantages of high biocompatibility, high biosafety, excellent photoresponse, and high tumor penetration ability. This review analyzes the use of AuNCs in tumor phototherapy in recent years from three aspects, namely, AuNCs in PDT, AuNCs in PTT, and AuNCs in combination therapy, and presents the high potential of AuNCs in cancer phototherapy. This review aims to provide readers with the unique advantages, diversified application approaches, and bright application prospects of AuNCs in phototherapy and to provide insights into strategies for applying AuNCs to tumor phototherapy.

show abstract

Antimicrobial photodynamic therapy mediated by methylene blue in surfactant vehicle as adjuvant to periodontal treatment. Randomized, controlled, double-blind clinical trial

Cited by 9 publications

References 22 publications

Photodynamic Therapy with Tolonium Chloride and a Diode Laser (635 nm) in the Non-Surgical Management of Periodontitis: A Clinical Study

Photodynamic Therapy with Tolonium Chloride and a Diode Laser (635 nm) in the Non-Surgical Management of Periodontitis: A Clinical Study

Evaluating the potency of laser-activated antimicrobial photodynamic therapy utilizing methylene blue as a treatment approach for chronic periodontitis

A Review on Gold Nanoclusters for Cancer Phototherapy

Contact Info

Product

Resources

About