Antimicrobial phenolic abietane diterpene from Lycopus europaeus L. (Lamiaceae)

Radulović, Niko S.; Denić, Marija S.; Stojanović-Radić, Zorica

doi:10.1016/j.bmcl.2010.07.063

Cited by 24 publications

(19 citation statements)

References 29 publications

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“…Diterpenes are reported to display a wide spectrum of biological activities, including antibacterial action (Almeida et al, 2008;Kuzma et al, 2007;Porto et al, 2009aPorto et al, , 2009b. Diterpenoids, and particularly clerodanes, isolated from species of Salvia were also shown to possess antimicrobial activity (Fonseca et al, 2013;Kuzma et al, 2007;Radulovic et al, 2010;Stavri et al, 2009;Ulubelen, 2003;Wu et al, 2012). Our results confirm the contention that clerodanes and especially the group of oxylipins, can be considered as a source of new and interesting antimicrobial agents that deserve further study.…”

Section: Discussionsupporting

confidence: 86%

Antibacterial compounds from Salvia adenophora Fernald (Lamiaceae)

et al. 2015

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Section: Discussionsupporting

confidence: 86%

Antibacterial compounds from Salvia adenophora Fernald (Lamiaceae)

et al. 2015

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“…The long‐time established use of plant extracts to treat human infections directed researchers to search for antibacterial agents from plant sources, or their hemisynthezised derivates, a promising approach, corroborated by the number of papers published in recent years (Newman and Cragg, ; van Vuuren and Viljoen, ). Among natural compounds, abietane diterpenes with phenolic and quinonic moieties are known to be interesting plant metabolites with diverse pharmacological activities, namely, antimicrobial (Radulović et al ., ; Hanson, ; van Vuuren, ; Hanson, ; Hanson, ; Hanson, ; Hanson, ), antitubercular (Rijo et al ., ; Hanson, ) and cytotoxic (Fronza et al ., ; Hanson, ; Hanson, ). However, a literature survey does not reveal significant attempts to modulate these activities on royleanone abietanes.…”

Section: Introductionmentioning

confidence: 99%

In vitro Antimicrobial Activity of Royleanone Derivatives Against Gram‐Positive Bacterial Pathogens

Rijo

Duarte

Francisco

et al. 2013

Phytotherapy Research

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Infections caused by multiresistant bacterial pathogens are a significant problem worldwide, turning the search for natural compounds to act as alternatives to antibiotics of major importance. The aim of the present study was to investigate the in vitro antimicrobial activity of 7α‐acetoxy‐6β‐hydroxyroyleanone (1), isolated from Plectranthus grandidentatus (Lamiaceae), and 11 additional royleanone abietane derivatives of 1 (2–12) against important Gram‐positive human bacterial pathogens. Results showed that the aromatic and alkylic esters 2, 3 and 5 are more active than 1 against Enterococcus and Staphylococcus (minimum inhibitory concentration (MIC) values ranging from 0.98 to 62.50 µg/mL). Moreover, 7α‐acetoxy‐6β‐hydroxy‐12‐O‐(4‐chloro)benzoylroyleanone (2) gave rise to a new antibacterial‐prototype (MIC values of 3.91–15.63 µg/mL against Staphylococcus and of 0.98–3.91 µg/mL against Enterococcus). The results showed that the compounds under analysis also present antimicrobial activity against resistant bacteria. The hydrophobic extra‐interactions with bacterial targets seem to play an important role on the activity of royleanones derivatives. Copyright © 2013 John Wiley & Sons, Ltd.

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“…The plant's juice yields a black dye, supposedly used by gypsies to tan their skin in order to mimic Egyptians in Europe, and hence the common name of gypsywort. L. europaeus is reputed to have medicinal qualities, often attributed to its phenolic compounds [1][2][3], and has been used traditionally as an astringent, cosmetic, narcotic and refrigerant [4]. Extracts from Lycopi europaei herba are traditionally used in patients with slight hyperthyroidism with vegetative-nervous disturbances as well as in tenseness and pain of the mammary gland [5].…”

Section: Introductionmentioning

confidence: 99%

“…Recently, we also found an antimicrobial phenolic abietane-type diterpene, euroabienol, possessing an unusual oxygenation pattern of the C ring, in relatively high amount (1 %, w/w) in the fruit of this plant species [3]. This was surprising, as the plant was repeatedly shown to accumulate several different highly oxygenated isopimarane [7][8][9] and aliphatic diterpenes [10,11] in its aerial parts (leaves).…”

Section: Introductionmentioning

confidence: 99%

Fatty and Volatile Oils of the Gypsywort Lycopus europaeus L. and the Gaussian‐Like Distribution of its Wax Alkanes

Radulović

Denić

Stojanović-Radić³

et al. 2012

J Americ Oil Chem Soc

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. Fatty and volatile oils of the gypsywort lycopus europaeus L. and the gaussian-like distribution of its wax alkanes. JAOCS, 89 (12), 2165-2185. Fatty and volatile oils of the gypsywort lycopus europaeus L. and the gaussian-like distribution of its wax alkanes AbstractThe detailed analyses of the volatile essential oil and lipid profiles of the aerial parts from the blooming and fruit-forming stages of both ripe and unripe fruit of Lycopus europaeus (Lamiaceae) are presented. Both of these profiles are distinguished by components with a restricted occurrence in the Plant Kingdom. These rare compounds include (E)-hotrienol in the volatiles, numerous unusual fatty acids (such as very long chain, oddnumbered and branched-chain) in the bound lipids and a high amount of iso-and anteiso-alkanes in the epicuticular waxes. Furthermore, a Gaussian-like distribution of the relative amounts of the epicuticular wax alkanes was observed. These normal distributions could be interpreted as the end result of the work of elongase enzyme systems where the Gaussian parameter μ should match the length of the "ideal" fatty acid biosynthesised and σ would represent the error of this enzyme system. These curve parameters were shown to have a close relationship with ACL and CPI values usually utilised to describe the natural distribution of wax alkanes. The screening of L. europaeus essential oil for its in vitro antimicrobial activity showed that this oil possesses selectivity towards two gram-negative strains, E. coli and K. pneumoniae. europaeus essential oil for its in vitro antimicrobial activity showed that this oil possesses selectivity towards two Gram negative strains, E. coli and K. pneumoniae.

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Antimicrobial phenolic abietane diterpene from Lycopus europaeus L. (Lamiaceae)

Cited by 24 publications

References 29 publications

Antibacterial compounds from Salvia adenophora Fernald (Lamiaceae)

Antibacterial compounds from Salvia adenophora Fernald (Lamiaceae)

In vitro Antimicrobial Activity of Royleanone Derivatives Against Gram‐Positive Bacterial Pathogens

Fatty and Volatile Oils of the Gypsywort Lycopus europaeus L. and the Gaussian‐Like Distribution of its Wax Alkanes

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