Antibacterial compounds from Salvia adenophora Fernald (Lamiaceae)

Bisio, Angela; Schito, Anna Maria; Ebrahimi, Samad Nejad; Hamburger, Matthias; Mele, Giacomo; Piatti, Gabriella; Romussi, Giovanni; Piaz, Fabrizio Dal; Tommasi, Nunziatina De

doi:10.1016/j.phytochem.2014.10.033

Cited by 25 publications

(27 citation statements)

References 66 publications

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“…2), that were also isolated from S. adenophora showed significant inhibition on gram positive species, Staph. epidermidis having MICs in the range of 32-128 and 32-125 lg/ml respectively, while the standard antibiotics, penicillin G potassium salt (PG, 1-2 lg/ml) and oxacillin sodium salt (1-8 lg/ml) showed several fold higher activity in comparison to the above mentioned compounds (Bisio et al 2015).…”

Section: Antibacterial Activitymentioning

confidence: 99%

Bioactive phytochemicals from shoots and roots of Salvia species

et al. 2015

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The plants of the genus Salvia L. are important medicinal herbs of the Lamiaceae family and some of them such as S. officinalis (sage), S. miltiorrhiza (red sage, Danshen) and S. sclarea (clary sage) have been used as medicinal plants in the folk medicine of several countries. In this review, we discuss the reports that have examined Salvia species with the aim of isolation of pure compounds with different biological activities. The phytochemical analyses of various sage plants have reported 10 monoterpenoids (1-10), 1 sesquiterpenoid (11), 8 labdane (13-20), 15 ent-kaurane (21-35), 82 abietane, rearranged abietane and tanshinone (36-117), 3 icetexane (118-120), 43 clerodane (121-163), and 3 pimarane (164-166) diterpenoids with cytotoxic and antimicrobial, antiprotozoal, antioxidant, phytotoxic and insecticide effects. The other heavier terpenoids, including 3 sesterterpenes (167-169), 10 triterpenoids and b-sitosterol (170-180) have been introduced as minor bioactive compounds in the sage plants. Sahandinone (107), 6,7-dehydroroyleanone, 7-a-acetoxyroyleanone (40), and tanshinone like diterpenoids have been isolated from the roots' extracts of different Salvia species. On the other hand, several radical scavenger phenolic compounds like simple phenolics and caffeic acid derivatives (181-201) including rosmarinic acid, flavonoids (202-217) as well as phenolic diterpenoids, such as carnosol and carnosic acid have been isolated from the aerial parts of these plants. One pyrrole (218) and 3 antimicrobial oxylipins (219-221) are among the other less detected constituents in the members of Salvias. Furthermore, sages also synthesize antifungal, antileishmanial and antimalarial phytochemicals in their roots and shoots, which are reviewed in this paper. We also examine the allelopathic phenomena and the ecologically important phytochemicals identified in different parts of the sage plants. Finally, antifeedant and insecticide phenomena, which are due to the presence of volatile monoterpenes and clerodane diterpenes in these plants, are discussed. Considering the presence of diverse biologically active phytochemicals in the sage plants, they can be suggested as suitable candidates for the formulation of valuable natural medicines.

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Section: Antibacterial Activitymentioning

confidence: 99%

Bioactive phytochemicals from shoots and roots of Salvia species

et al. 2015

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“…epidermidis . 509 In contrast, lupulin A ( 822 ) showed clear activity against Gram-negative Ps. aeruginosa and E. coli (inhibitory zone 3–5 mm), 315 and hativenes A–C ( 827–829 ) showed potent activity against three Gram-negative rods ( E. coli, Ps.…”

Section: Biological Activitiesmentioning

confidence: 99%

Clerodane diterpenes: sources, structures, and biological activities

2016

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The clerodane diterpenoids are a widespread class of secondary metabolites and have been found in several hundreds of plant species from various families and in organisms from other taxonomic groups. These substances have attracted interest in recent years due to their notable biological activities, particularly insect antifeedant properties. In addition, the major active clerodanes of Salvia divinorum can be used as novel opioid receptor probes, allowing greater insight into opioid receptor-mediated phenomena, as well as opening additional areas for chemical investigation. This article provides extensive coverage of naturally occurring clerodane diterpenes discovered from 1990 until 2015, and follows up on the 1992 review by Merritt and Ley in this same journal. The distribution, chemotaxonomic significance, chemical structures, and biological activities of clerodane diterpenes are summarized. In the cases where sufficient information is available, structure activity relationship (SAR) correlations and mode of action of active clerodanes have been presented.

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“…(2S,5R,8R,9S,10R,15S)-2-b-Hydroxy-15-methoxy-16-oxo-15,16-dihydro-hardwickiic acid, a clerodane diterpenoid reported from Salvia adenophora Fernald by Bisio et al, (2015) contains methoxyfuranone ring similar to compound 2 with b-orientation of the methoxy group at C-15 (15(S)-configuration). The resemblance in 1 H and 13 C NMR data of methoxyfuranone ring in 2 with those of reported by Bisio et al, (2015) helped us to assign b-orientation of methoxy group at C-15. Ultimately, compound 2 was elucidated as shown in Fig.…”

Section: Resultsmentioning

confidence: 99%