Antimicrobial peptides: Promising alternatives in the post feeding antibiotic era

Wang, Jiajun; Dou, Xiujing; Song, Jing; Lyu, Yinfeng; Zhu, Xin; Xu, Lin; Li, Weizhong; Shan, Anshan

doi:10.1002/med.21542

Cited by 330 publications

(328 citation statements)

References 211 publications

Supporting

Mentioning

326

Contrasting

Order By: Relevance

“…In this study, two symmetric heptad repeat sequences were connected by a short loop, and the sequence was designed as XXRXXRRzzRRXXRXX-NH 2 , where X represents Phe (F), Ile (I), and Leu (L), while zz represents Gly-Gly (GG) or d-Pro-Gly (pG). The net charge was +6 and the hydrophobicity was 40%-60%, which is consistent with the statistical information on natural AMPs [2,18]. Hydrophobic amino acids F, I, and L were used to damage microbial cell membranes [19].…”

Section: Introductionsupporting

confidence: 77%

“…Most AMPs have unique mechanisms of killing bacteria, mainly involving membrane breaking, which endows them with the potential to be alternatives to antibiotics [2]. However, the progress of natural AMPs for therapeutic application is seriously hindered by their inherent defects (such as manufacturing costs, cytotoxicity, poor stability etc.)…”

Section: Discussionmentioning

confidence: 99%

“…1 Molecular weight (MW) was determined by mass spectrometry (MS). 2 The mean hydrophobicity (H) is the total hydrophobicity (sum of all residue hydrophobicity indices) divided by the number of residues. 3 The relative hydrophobic moment of a peptide is its hydrophobic moment relative to that of a perfectly amphiphilic peptide.…”

Section: Peptide Design and Characteristicsmentioning

confidence: 99%

“…The development of antibacterial reagents with new antibacterial mechanisms is imminent [1]. As an important part of innate immunity, antimicrobial peptides (AMPs) form the first line of defense against antimicrobial infections, as found in many microorganisms including insects, plants, and animals [2]. Furthermore, AMPs are known for their anti-inflammatory properties, anti-biofilm formation, promotion of tissue and injury repair, and anti-cancer effects [2][3][4].…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

High Cell Selectivity and Bactericidal Mechanism of Symmetric Peptides Centered on d-Pro–Gly Pairs

Jia

Wang

Zhang

et al. 2020

IJMS

View full text Add to dashboard Cite

Antimicrobial peptides (AMPs) have a unique action mechanism that can help to solve global problems in antibiotic resistance. However, their low therapeutic index and poor stability seriously hamper their development as therapeutic agents. In order to overcome these problems, we designed peptides based on the sequence template XXRXXRRzzRRXXRXX-NH 2 , where X represents a hydrophobic amino acid like Phe (F), Ile (I), and Leu (L), while zz represents Gly-Gly (GG) or d-Pro-Gly (pG). Showing effective antimicrobial activity against Gram-negative bacteria and low toxicity, designed peptides had a tendency to form an α-helical structure in membrane-mimetic environments. Among them, peptide LR pG (X: L, zz: pG) showed the highest geometric mean average treatment index (GM TI = 73.1), better salt, temperature and pH stability, and an additive effect with conventional antibiotics. Peptide LR pG played the role of anti-Gram-negative bacteria through destroying the cell membrane. In addition, peptide LR pG also exhibited an anti-inflammatory activity by effectively neutralizing endotoxin. Briefly, peptide LR pG has the potential to serve as a therapeutic agent to reduce antibiotic resistance owing to its high therapeutic index and great stability.

show abstract

Section: Introductionsupporting

confidence: 77%

Section: Discussionmentioning

confidence: 99%

Section: Peptide Design and Characteristicsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

High Cell Selectivity and Bactericidal Mechanism of Symmetric Peptides Centered on d-Pro–Gly Pairs

Jia

Wang

Zhang

et al. 2020

IJMS

View full text Add to dashboard Cite

show abstract

“…Its microbicidal action is verified on gram‐negative microorganisms, including Staphylococcus aureus , Acinetobacter baumannii , and Pseudomonas aeruginosa . Compared to other known microbicidal agents, melatonin may exert its unique antibacterial function by decreasing the intracellular substrates, lipid levels, and metal binding capacity …”

Section: Melatonin Signaling Modulates the Intestinal Immune Functionmentioning

confidence: 99%

Melatonin mediates mucosal immune cells, microbial metabolism, and rhythm crosstalk: A therapeutic target to reduce intestinal inflammation

Zhang

Reíter

et al. 2019

Medicinal Research Reviews

105

View full text Add to dashboard Cite

Nowadays, melatonin, previously considered only as a pharmaceutical product for rhythm regulation and sleep aiding, has shown its potential as a co‐adjuvant treatment in intestinal diseases, however, its mechanism is still not very clear. A firm connection between melatonin at a physiologically relevant concentration and the gut microbiota and inflammation has recently established. Herein, we summarize their crosstalk and focus on four novelties. First, how melatonin is synthesized and degraded in the gut and exerts potentially diverse phenotypic effects through its diverse metabolites. Second, how melatonin mediates the activation and proliferation of intestinal mucosal immune cells with paracrine and autocrine properties. By modulating T/B cells, mast cells, macrophages and dendritic cells, melatonin immunomodulatory involved in regulating T‐cell differentiation, intervening T/B cell interaction and attenuating the production of pro‐inflammatory factors, achieving its antioxidant action via specific receptors. Third, how melatonin exerts antimicrobial action and modulates microbial components, such as lipopolysaccharide, amyloid‐β peptides via nuclear factor κ‐light‐chain‐enhancer of activated B cells (NF‐κB) or signal transducers and activators of transcription (STAT1) pathway to modulate intestinal immune function in immune‐pineal axis. The last, how melatonin mediates the effect of intestinal bacterial activity signals on the body rhythm system through the NF‐κB pathway and influences the mucosal epithelium oscillation via clock gene expression. These processes are achieved at mitochondrial and nuclear levels to control the host immune cell development. Considering unclear mechanisms and undiscovered actions of melatonin in gut‐microbiome‐immune axis, it's time to reveal them and provide new insight for the outlook of melatonin as a potential therapeutic target in the treatment and management of intestinal diseases.

show abstract

Synthetic Polymers with Finely Regulated Monomer Sequences: Properties and Emerging Applications

Laurent

Szweda

Lutz

2022

Macromolecular Engineering

View full text Add to dashboard Cite

The design of synthetic polymers with controlled monomer sequences is an important emerging trend in polymer science. This new field of research is bio‐inspired by sequence‐defined biopolymers such as proteins and nucleic acids. The chemical synthesis of nonnatural sequence‐controlled polymers (SCPs) has been described in several reviews. However, there is currently little information about the properties and applications of these polymers. In this context, the aim of this article is to give a comprehensive view on these aspects. After a general introduction and a short section about the synthesis of SCPs, the physicochemical properties of these synthetic macromolecules are described in detail. For instance, emphasis is put on the bulk and solution self‐assembly of SCPs. In the last part of this article, potential applications are reviewed and discussed. Overall, SCPs, which are more time‐consuming to synthesize than regular commodity polymers, are not meant to be used in high‐scale applications but more in specialty technologies with high‐added value. For instance, application areas such as data storage, anti‐counterfeiting technologies, catalysis, and photovoltaics are described in this article.

show abstract

Antimicrobial peptides: Promising alternatives in the post feeding antibiotic era

Cited by 330 publications

References 211 publications

High Cell Selectivity and Bactericidal Mechanism of Symmetric Peptides Centered on d-Pro–Gly Pairs

High Cell Selectivity and Bactericidal Mechanism of Symmetric Peptides Centered on d-Pro–Gly Pairs

Melatonin mediates mucosal immune cells, microbial metabolism, and rhythm crosstalk: A therapeutic target to reduce intestinal inflammation

Synthetic Polymers with Finely Regulated Monomer Sequences: Properties and Emerging Applications

Contact Info

Product

Resources

About