Antimicrobial Peptides: Diversity and Perspectives for Their Biomedical Application

López‐Meza, Joel E.; Aguilar, Alejandra Ochoa-Zarzosa José A.; Lara, Pedro Damián Loeza

doi:10.5772/13058

Cited by 5 publications

(7 citation statements)

References 134 publications

(161 reference statements)

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“…Bioactive peptides are essential components of plants defense mechanisms, with extraordinary physiological importance, providing fast protection against bacterial and fungal infections (Jenssen et al, 2006;Loṕez-Meza et al, 2011;Salas et al, 2015). Plant AMPs not only display microbicide activities but are also involved in cellular signaling (Salas et al, 2015).…”

Section: Plants As Source Of Ampsmentioning

confidence: 99%

“…Plant AMPs not only display microbicide activities but are also involved in cellular signaling (Salas et al, 2015). Several active peptides have been extracted and isolated from roots, flowers, seeds, stems and leaves and are classified based on their amino acids sequence, position and number of cysteine residues involved in the disulfide bridge formation (Loṕez-Meza et al, 2011). Ten families of plant AMPs have been described (Loṕez-Meza et al, 2011) and the best-studied groups are defensins, thionins and snakins (Jenssen et al, 2006;Loṕez-Meza et al, 2011;Huan et al, 2020).…”

Section: Plants As Source Of Ampsmentioning

confidence: 99%

“…Several active peptides have been extracted and isolated from roots, flowers, seeds, stems and leaves and are classified based on their amino acids sequence, position and number of cysteine residues involved in the disulfide bridge formation (Loṕez-Meza et al, 2011). Ten families of plant AMPs have been described (Loṕez-Meza et al, 2011) and the best-studied groups are defensins, thionins and snakins (Jenssen et al, 2006;Loṕez-Meza et al, 2011;Huan et al, 2020). The first plant-derived AMP is purothionin, which displays activity against Corynebacterium fascians, Pseudomonas solanacearum, Corynebacterium poinsettia (de Caleya et al, 1972).…”

Section: Plants As Source Of Ampsmentioning

confidence: 99%

“…The PvD1 peptide is a defensin from Phaseolus vulgaris, which inhibits growth of yeasts, such as Candida albicans, Candida tropicalis and Saccharomyces cerevisiae (Mello et al, 2011). Thionins, composed by 45 to 47 amino acids, are basic peptides found in several plant tissues, which are toxic to bacteria and phytopathogenic fungi (Loṕez-Meza et al, 2011). Snakins are small peptides with 12 cysteine residues forming six disulphide bridges, essential for their biological activity (Meneguetti et al, 2017).…”

Section: Plants As Source Of Ampsmentioning

confidence: 99%

“…Animal AMPs are produced at the sites that are constantly exposed to microbes, such as skin and mucosal barriers (Loṕez-Meza et al, 2011). Various AMPs have been isolated from invertebrates and many vertebrate species (including fish, amphibians, and mammals).…”

Section: Animals As Source Of Ampsmentioning

confidence: 99%

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Antibiotics are essential drugs used to treat pathogenic bacteria, but their prolonged use contributes to the development and spread of drug-resistant microorganisms. Antibiotic resistance is a serious challenge and has led to the need for new alternative molecules less prone to bacterial resistance. Antimicrobial peptides (AMPs) have aroused great interest as potential next-generation antibiotics, since they are bioactive small proteins, naturally produced by all living organisms, and representing the first line of defense against fungi, viruses and bacteria. AMPs are commonly classified according to their sources, which are represented by microorganisms, plants and animals, as well as to their secondary structure, their biosynthesis and their mechanism of action. They find application in different fields such as agriculture, food industry and medicine, on which we focused our attention in this review. Particularly, we examined AMP potential applicability in wound healing, skin infections and metabolic syndrome, considering their ability to act as potential Angiotensin-Converting Enzyme I and pancreatic lipase inhibitory peptides as well as antioxidant peptides. Moreover, we argued about the pharmacokinetic and pharmacodynamic approaches to develop new antibiotics, the drug development strategies and the formulation approaches which need to be taken into account in developing clinically suitable AMP applications.

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