Antimicrobial peptides and the gut microbiome in inflammatory bowel disease

Gubatan, John; Holman, Derek; Puntasecca, Christopher J; Polevoi, Danielle; Rubin, Samuel J.; Rogalla, Stephan

doi:10.3748/wjg.v27.i43.7402

Cited by 50 publications

(46 citation statements)

References 137 publications

(187 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Dimension reduction analysis indicated that the expression of SDEGs in CD is closer to IgAN than to UC, which suggests there may be more genetic effect similarities between CD and IgAN. A cross-sectional analysis also showed that the frequency of IgAN was significantly higher in patients with CD (11/207, 5.3%) than in those with UC (2/220, 0.9%) ( 28 ), this may be related to more inflammatory infiltration and paneth cells in the ileum than colorectum ( 29 ). In addition, MVP and PDXK with higher AUC in 64SDEGs were identified as potential biomarkers in the blood of IgAN and IBD, which may facilitate the diagnosis of these diseases.…”

Section: Discussionmentioning

confidence: 95%

“…These TFs were up-regulated in IgAN and IBD and were correlated with 18 SDEGs. TFs could act both as activators and repressors of gene expression at the transcriptional level ( 29 ), changing the expression of the unique TFs to treat IgAN and IBD may be more effective with less effort. Moreover, three miRNAs (hsa-miR-146, hsa-miR-21 and hsa-miR-320) were screened using HMDD, which could down-regulate the expression of 14 SDEGs at the posttranscriptional level and play an important role in the pathophysiology of IgAN and IBD ( 30 ).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Differentiation of T Helper 17 Cells May Mediate the Abnormal Humoral Immunity in IgA Nephropathy and Inflammatory Bowel Disease Based on Shared Genetic Effects

Qing

et al. 2022

Front. Immunol.

View full text Add to dashboard Cite

BackgroundIgA nephropathy (IgAN) is the most frequent glomerulonephritis in inflammatory bowel disease (IBD). However, the inter-relational mechanisms between them are still unclear. This study aimed to explore the shared gene effects and potential immune mechanisms in IgAN and IBD.MethodsThe microarray data of IgAN and IBD in the Gene Expression Omnibus (GEO) database were downloaded. The differential expression analysis was used to identify the shared differentially expressed genes (SDEGs). Besides, the shared transcription factors (TFs) and microRNAs (miRNAs) in IgAN and IBD were screened using humanTFDB, HMDD, ENCODE, JASPAR, and ChEA databases. Moreover, weighted gene co-expression network analysis (WGCNA) was used to identify the shared immune-related genes (SIRGs) related to IgAN and IBD, and R software package org.hs.eg.db (Version3.1.0) were used to identify common immune pathways in IgAN and IBD.ResultsIn this study, 64 SDEGs and 28 SIRGs were identified, and the area under the receiver operating characteristic curve (ROC) of 64 SDEGs was calculated and two genes (MVP, PDXK) with high area under the curve (AUC) in both IgAN and IBD were screened out as potential diagnostic biomarkers. We then screened 3 shared TFs (SRY, MEF2D and SREBF1) and 3 miRNAs (hsa-miR-146, hsa-miR-21 and hsa-miR-320), and further found that the immune pathways of 64SDEGs, 28SIRGs and 3miRNAs were mainly including B cell receptor signaling pathway, FcγR-mediated phagocytosis, IL-17 signaling pathway, toll-like receptor signaling pathway, TNF signaling pathway, TRP channels, T cell receptor signaling pathway, Th17 cell differentiation, and cytokine-cytokine receptor interaction.ConclusionOur work revealed the differentiation of Th17 cells may mediate the abnormal humoral immunity in IgAN and IBD patients and identified novel gene candidates that could be used as biomarkers or potential therapeutic targets.

show abstract

Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 99%

Differentiation of T Helper 17 Cells May Mediate the Abnormal Humoral Immunity in IgA Nephropathy and Inflammatory Bowel Disease Based on Shared Genetic Effects

Qing

et al. 2022

Front. Immunol.

View full text Add to dashboard Cite

show abstract

“…AMPs are convoluted evolving compounds produced by gut epithelial cells, paneth cells, and immunological cells in the digestive tract ( Figure 3 ). 65 AMPs, such as α- and β- defensins, are secreted by localized immune cell types, namely macrophages, T cells, B cells and mast cells (MC). 66 Furthermore, MCs can produce the AMP cathelicidin and contribute to microbiome-tissue homeostasis in the dermis.…”

Section: Methodsmentioning

confidence: 99%

Impact of gut microbiome on skin health: gut-skin axis observed through the lenses of therapeutics and skin diseases

et al. 2022

View full text Add to dashboard Cite

The human intestine hosts diverse microbial communities that play a significant role in maintaining gut-skin homeostasis. When the relationship between gut microbiome and the immune system is impaired, subsequent effects can be triggered on the skin, potentially promoting the development of skin diseases. The mechanisms through which the gut microbiome affects skin health are still unclear. Enhancing our understanding on the connection between skin and gut microbiome is needed to find novel ways to treat human skin disorders. In this review, we systematically evaluate current data regarding microbial ecology of healthy skin and gut, diet, pre- and probiotics, and antibiotics, on gut microbiome and their effects on skin health. We discuss potential mechanisms of the gut-skin axis and the link between the gut and skin-associated diseases, such as psoriasis, atopic dermatitis, acne vulgaris, rosacea, alopecia areata, and hidradenitis suppurativa. This review will increase our understanding of the impacts of gut microbiome on skin conditions to aid in finding new medications for skin-associated diseases.

show abstract

“…These peptides can directly regulate gut microbiota, which affect the development of intestinal inflammation. 26 , 27 It has also been reported that Nod2 signaling in CD11c + cells can drive the Th2-type immune response with the synergistic signals of tumor necrosis factor receptor superfamily member 4 ligand (OX40L) and thymic stromal lymphopoietin receptor (TSLPR). 28 Mutations in NOD2 lead to decreased the level of IL-10, but increase in mucosal bacteria.…”

Section: Inflammatory Bowel Diseasementioning

confidence: 99%

Helminth Therapy for Immune-Mediated Inflammatory Diseases: Current and Future Perspectives

Shi¹,

Xu²,

Wang³

et al. 2022

JIR

View full text Add to dashboard Cite

Inflammatory bowel disease and allergic asthma, as typical immune-mediated inflammatory diseases (IMIDs), are associated with immune imbalance caused by complex interactions among environmental, genetic and bacterial factors. The changing immune imbalance of IMIDs not only causes serious pathological damages but also increases the difficulty of treatment. Helminths or helminth-derived molecules have been increasingly employed to treat IMIDs due to their immunoregulatory ability. Since helminth infection is not an appropriate treatment direction due to the complex immunoregulation and safety concerns, one of the new therapies is to harness the immunoregulation induced by the identified helminth-derived molecules using immune indexes as a guide. This review discusses the pathogenesis of inflammatory bowel disease and allergic asthma, and summarizes the therapeutic effect of helminths and the immunoregulatory mechanisms induced by helminth-derived molecules proposing therapeutic regimens.

show abstract

Antimicrobial peptides and the gut microbiome in inflammatory bowel disease

Cited by 50 publications

References 137 publications

Differentiation of T Helper 17 Cells May Mediate the Abnormal Humoral Immunity in IgA Nephropathy and Inflammatory Bowel Disease Based on Shared Genetic Effects

Differentiation of T Helper 17 Cells May Mediate the Abnormal Humoral Immunity in IgA Nephropathy and Inflammatory Bowel Disease Based on Shared Genetic Effects

Impact of gut microbiome on skin health: gut-skin axis observed through the lenses of therapeutics and skin diseases

Helminth Therapy for Immune-Mediated Inflammatory Diseases: Current and Future Perspectives

Contact Info

Product

Resources

About