Antimicrobial modification of PLA scaffolds with ascorbic and fumaric acids via plasma treatment

Popelka, Anton; Abdulkareem, Asma; Mahmoud, Abdelrahman; Nassr, Mohammed G.; Al-Ruweidi, Mahmoud Khatib A A; Mohamoud, Khalid J.; Hussein, Mohammed; Lehocký, Marián; Vesela, Daniela; Humpolíček, Petr; Kasák, Peter

doi:10.1016/j.surfcoat.2020.126216

Cited by 31 publications

(24 citation statements)

References 55 publications

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“…They found that an increase in plasma exposure results in a decrease of wettability and polar groups on the surface. This is also consistent with that reported by Popelka et al [ 47 ]…”

Section: Resultssupporting

confidence: 94%

“…They found that an increase in plasma exposure results in a decrease of wettability and polar groups on the surface. This is also consistent with that reported by Popelka et al [47] Recently, Luque-Agudo et al [48] reported that when plasma is applied for a long time, the incorporation of polar groups saturates, recombining and causing degradation. The above is in concordance with the results reported by Suganya et al [49] As can be seen in the low resolution XPS spectra two main contributions corresponding to C1s (at 285 eV) and O1s (located at 533 eV) for modified and unmodified samples due to the chemical structure of the polymers such PCL [50] (see Figure 1) and PLA (see Figure 2) were observed.…”

Section: Surface Characterization Of the Scaffolds By Ftir-atr And Xpssupporting

confidence: 91%

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Enhancement of chemical, physical, and surface properties of electrospun PCL/PLA blends by means of air plasma treatment

Can-Herrera

Oliva

Cervantes‐Uc

2022

Polymer Engineering & Sci

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Polycaprolactone (PCL) and poly(lactic acid) (PLA) are polymers with unique individual features, but their mixing can produce a new biodegradable material with well-balanced properties, although with a disadvantage that both are highly hydrophobic materials. To improve this drawback, electrospun PCL/PLA blends with various weight ratios were superficially modified by air plasma. The changes undergone by the nanofibers were characterized using spectroscopic and microscopic techniques; water contact angle (WCA) was also determined. We demonstrated that the electrospun PCL/PLA blends did not suffer morphological changes, although it was observed an increase in the roughness and the O/C ratio (by XPS analysis) and, decrease in WCA values, when the PCL content dominates in the blend after the treatment. The surface characteristics of the scaffolds PCL/PLA blends can be improved after modification with plasma and by tuning the content of its components.

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“…They found that an increase in plasma exposure results in a decrease of wettability and polar groups on the surface. This is also consistent with that reported by Popelka et al [ 47 ]…”

Section: Resultssupporting

confidence: 94%

Section: Surface Characterization Of the Scaffolds By Ftir-atr And Xpssupporting

confidence: 91%

Enhancement of chemical, physical, and surface properties of electrospun PCL/PLA blends by means of air plasma treatment

Can-Herrera

Oliva

Cervantes‐Uc

2022

Polymer Engineering & Sci

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“…Therefore, the development of PLA based films with enhanced antimicrobial properties is highly demanded. For this purpose, the PLA surface can be modified with antimicrobial agents using the plasma technique as an effective radical initiator for the grafting processes [38]. Due to their nontoxicity, biocompatibility, and antimicrobial properties, ascorbic acid (ASA) and fumaric acid (FA) are promising materials for this modification [39,40].…”

Section: Introductionmentioning

confidence: 99%

Surface Modification of Poly(lactic acid) Film via Cold Plasma Assisted Grafting of Fumaric and Ascorbic Acid

et al. 2021

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Plant-based materials have found their application in the packaging with a yearly growing production rate. These naturally biodegradable polymers are obtained from renewable and sustainable natural resources with reduced environmental impact and affordable cost. These materials have found their utilization in fully-renewable plant-based packaging products, such as Tetra Pak®-like containers, by replacing commonly-used polyethylene as the polymer component. Poly(lactic acid) (PLA) is one of the representative plant-based polymers because of its eco-friendliness and excellent chemical and mechanical properties. In this work, a PLA surface was modified by various food additives, namely ascorbic acid (ASA) and fumaric acid (FA), using plasma-initiated grafting reactions in order to improve the surface and adhesion properties of PLA. Various analytical and microscopic techniques were employed to prove the grafting process. Moreover, the improved adhesion of the modified PLA foil to aluminum (Al) foil in a laminate configuration was proven by peel resistance measurements. The peel resistance of modified PLA increased by 74% and 184% for samples modified by ASA and FA, respectively, compared with untreated PLA.

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“…Thus, for example, Hegemann et al [36] showed that the deposition of ultra-thin layers by plasma enables the long-lasting adjustment of wetting properties, using siloxane-based or fluorocarbon films, and the reduction of the friction coefficient, applying siloxane or a-C:H coatings, as shown in Figure 8. Vast number of studies used plasma pretreatment step in order to enhance the adhesion of bioactive coatings on highly non-reactive polymeric medical materials like polyethylene (PE) [39], polycarbonate-urethane (PCU) [35], polylactic acid (PLA) [40], polytetrafluoroethylene (PTFE) [41,42]. [38].…”

Section: Enhanced Surface Hydrophilicity and Cell Adhesionmentioning

confidence: 99%

Cold Plasma Systems and Their Application in Surface Treatments for Medicine

Tabarés

Junkar

2021

Molecules

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In this paper, a review of cold plasma setups and the physical and chemical processes leading to the generation of active species is presented. The emphasis is given to the interaction of cold plasmas with materials used in medical applications, especially medical implants as well as live cells. An overview of the different kinds of plasmas and techniques used for generation of active species, which significantly alter the surface properties of biomaterials is presented. The elemental processes responsible for the observed changes in the physio-chemical properties of surfaces when exposed to plasma are described. Examples of ongoing research in the field are given to illustrate the state-of-the-art at the more conceptual level.

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Antimicrobial modification of PLA scaffolds with ascorbic and fumaric acids via plasma treatment

Cited by 31 publications

References 55 publications

Enhancement of chemical, physical, and surface properties of electrospun PCL/PLA blends by means of air plasma treatment

Enhancement of chemical, physical, and surface properties of electrospun PCL/PLA blends by means of air plasma treatment

Surface Modification of Poly(lactic acid) Film via Cold Plasma Assisted Grafting of Fumaric and Ascorbic Acid

Cold Plasma Systems and Their Application in Surface Treatments for Medicine

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