Antimicrobial hydrogels composed of chitosan and sulfated polysaccharides of red microalgae

Liberman, Gal Netanel; Ochbaum, Guy; Bitton, Ronit; Arad, Shoshana

doi:10.1016/j.polymer.2020.123353

Cited by 29 publications

(11 citation statements)

References 50 publications

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“…Also, the antibacterial effect of foams directly proportionates to the amount of water-soluble chitosan. The reason why the samples were not effective against E.coli bacteria in this study; It was thought that the chitosan concentration lower than previous studies 85,86 . On the other hand, it has been reported earlier gram-negative bacteria are more resistant to antibacterial polymers and even show no effect, compared to gram-positive bacteria 87,88 .…”

Section: Antibacterial Activity Testmentioning

confidence: 60%

A Study on Physical, Morphological and Antibacterial Properties of Bio Polymers Reinforced Polyvinyl Acetate Foams

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Özen

Ergün³

et al. 2022

Mat. Res.

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In this study, foaming-agent free novel polyvinyl acetate (PVAc) foams reinforced with bio polymers were manufactured through freeze-drying technique. The physical, morphological and antibacterial properties of foams which were reinforced with different ratio of zinc borate and water-soluble chitosan were investigated according to relevant standards. The PVAc foams showed low densities (0.12 g/cm 3 -0.21 g/cm 3 ) and high porosity rates (87.50% -79.05%). The results showed that although the foams have no antibacterial character against Escherichia Coli, they have antibacterial character against Staphylococcus Aureus bacteria. This study mainly focusses on physical and morphological properties of the foams. However, researchers also performed accelerated weathering tests to determine its usability in different industries. The effects of accelerated weathering on the surface of foams were investigated by measuring surface color. The highest color difference was determined 8.09. This foam can be used as a low-density packaging material and/or medical box with its promising physical and morphological properties with hazardous-chemical free structure.

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Section: Antibacterial Activity Testmentioning

confidence: 60%

A Study on Physical, Morphological and Antibacterial Properties of Bio Polymers Reinforced Polyvinyl Acetate Foams

Yıldırım

Özen

Ergün³

et al. 2022

Mat. Res.

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“…SEM was used to examine the detailed structures inside the SPHHs in the dry states (freeze-dried and vacuum-dried samples) [ 46 , 47 ]. This was conducted to characterize the surface morphology, texture, and porosity of the SPHHs, as shown in Figure 4 a–b’.…”

Section: Resultsmentioning

confidence: 99%

pH-Responsive Super-Porous Hybrid Hydrogels for Gastroretentive Controlled-Release Drug Delivery

Juthi

Wang

et al. 2023

Pharmaceutics

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Super-porous hydrogels are considered a potential drug delivery network for the sedation of gastric mechanisms with retention windows in the abdomen and upper part of the gastrointestinal tract (GIT). In this study, a novel pH-responsive super-porous hybrid hydrogels (SPHHs) was synthesized from pectin, poly 2-hydroxyethyl methacrylate (2HEMA), and N, N methylene-bis-acrylamide (BIS) via the gas-blowing technique, and then loaded with a selected drug (amoxicillin trihydrate, AT) at pH 5 via an aqueous loading method. The drug-loaded SPHHs-AT carrier demonstrated outstanding (in vitro) gastroretentive drug delivery capability. The study attributed excellent swelling and delayed drug release to acidic conditions at pH 1.2. Moreover, in vitro controlled-release drug delivery systems at different pH values, namely, 1.2 (97.99%) and 7.4 (88%), were studied. These exceptional features of SPHHs—improved elasticity, pH responsivity, and high swelling performance—should be investigated for broader drug delivery applications in the future.

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“…Lyophilized Fmoc-Phe-Phe-OH (FmocFF) peptide was purchased from Bachem (Budendorf, Switzerland) and the PS was produced as previously described [ 16 , 27 ]. The 3-[4,5-dimethylthiazole-2-yl]-2,5-diphenyltetrazolium bromide (MTT), Alizarin red, Cavacurcumin, and 9 mm diameter × 2 mm depth silicone isolators were purchased from Sigma Aldrich (Rehovot, Israel).…”

Section: Methodsmentioning

confidence: 99%

“…Furthermore, it is resistant to hyaluronidase and stable at a wide range of temperatures and pH levels [ 13 ]. The polysaccharide has been studied as a lubricating agent [ 14 ] for its potential in pharmaceutics, food and drug delivery [ 15 ], and as a potential for wound dressing material when combined with chitosan and zinc ions [ 11 , 16 , 17 ]. Despite the significant advantages, polysaccharide shows inadequate mechanical properties and fast degradation rates [ 18 , 19 ], similar to other polysaccharides, limiting its use in tissue engineering.…”

Section: Introductionmentioning

confidence: 99%

Thixotropic Red Microalgae Sulfated Polysaccharide-Peptide Composite Hydrogels as Scaffolds for Tissue Engineering

et al. 2022

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Sulfated polysaccharides of red marine microalgae have recently gained much attention for biomedical applications due to their anti-inflammatory and antioxidant properties. However, their low mechanical properties limit their use in tissue engineering. Herein, to enhance the mechanical properties of the sulfated polysaccharide produced by the red marine microalga, Porphyridium sp. (PS), it was integrated with the fluorenylmethoxycarbonyl diphenylalanine (FmocFF) peptide hydrogelator. Transparent, stable hydrogels were formed when mixing the two components at a 1:1 ratio in three different concentrations. Electron microscopy showed that all hydrogels exhibited a nanofibrous structure, mimicking the extracellular matrix. Furthermore, the hydrogels were injectable, and tunable mechanical properties were obtained by changing the hydrogel concentration. The composite hydrogels allowed the sustained release of curcumin which was controlled by the change in the hydrogel concentration. Finally, the hydrogels supported MC3T3-E1 preosteoblasts viability and calcium deposition. The synergy between the sulfated polysaccharide, with its unique bioactivities, and FmocFF peptide, with its structural and mechanical properties, bears a promising potential for developing novel tunable scaffolds for tissue engineering that may allow cell differentiation into various lineages.

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Antimicrobial hydrogels composed of chitosan and sulfated polysaccharides of red microalgae

Cited by 29 publications

References 50 publications

A Study on Physical, Morphological and Antibacterial Properties of Bio Polymers Reinforced Polyvinyl Acetate Foams

A Study on Physical, Morphological and Antibacterial Properties of Bio Polymers Reinforced Polyvinyl Acetate Foams

pH-Responsive Super-Porous Hybrid Hydrogels for Gastroretentive Controlled-Release Drug Delivery

Thixotropic Red Microalgae Sulfated Polysaccharide-Peptide Composite Hydrogels as Scaffolds for Tissue Engineering

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