Antimicrobial gum bio-based nanocomposites and their industrial and biomedical applications

Zare‬, Ehsan Nazarzadeh; Makvandi, Pooyan; Borzacchiello, Assunta; Tay, Franklin R.; Ashtari, Behnaz; Padil, Vinod V.T.

doi:10.1039/c9cc08207g

Cited by 88 publications

(24 citation statements)

References 152 publications

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“…. In light of this, a number of research have been devoted on the solubility enhancements or encapsulation of curcumin targeted drug delivery platforms for biomedical applications (Deljoo et al, 2019;Zare et al, 2019a;Zare et al, 2019b). For instance, a number of nanoscale carriers (e.g., micelles, liposomes, polymeric nanocarriers, lipid nanoparticles, and carbon nanotubes) have been developed to encapsulate hydrophobic active compounds such as curcumin (Bian and Guo, 2020;Hu et al, 2020;Varshosaz et al, 2020;Zhao et al, 2020).…”

Section: Curcumin: An Overview Of the Pharmacological Impacts And Limmentioning

confidence: 99%

Toward Regulatory Effects of Curcumin on Transforming Growth Factor-Beta Across Different Diseases: A Review

et al. 2020

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Immune response, proliferation, migration and angiogenesis are juts a few of cellular events that are regulated by transforming growth factor-β (TGF-β) in cells. A number of studies have documented that TGF-β undergoes abnormal expression in different diseases, e.g., diabetes, cancer, fibrosis, asthma, arthritis, among others. This has led to great fascination into this signaling pathway and developing agents with modulatory impact on TGF-β. Curcumin, a natural-based compound, is obtained from rhizome and roots of turmeric plant. It has a number of pharmacological activities including antioxidant, anti-inflammatory, anti-tumor, anti-diabetes and so on. Noteworthy, it has been demonstrated that curcumin affects different molecular signaling pathways such as Wnt/β-catenin, Nrf2, AMPK, mitogen-activated protein kinase and so on. In the present review, we evaluate the potential of curcumin in regulation of TGF-β signaling pathway to corelate it with therapeutic impacts of curcumin. By modulation of TGF-β (both upregulation and down-regulation), curcumin ameliorates fibrosis, neurological disorders, liver disease, diabetes and asthma. Besides, curcumin targets TGF-β signaling pathway which is capable of suppressing proliferation of tumor cells and invading cancer cells.

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Section: Curcumin: An Overview Of the Pharmacological Impacts And Limmentioning

confidence: 99%

Toward Regulatory Effects of Curcumin on Transforming Growth Factor-Beta Across Different Diseases: A Review

et al. 2020

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“…Several researchers have reviewed and worked on antimicrobial systems, both nanometals and biobased materials [14][15][16]. Seaweed-based films have been used as antioxidants and antimicrobial packaging.…”

Section: Introductionmentioning

confidence: 99%

Extracted Compounds from Neem Leaves as Antimicrobial Agent on the Physico-Chemical Properties of Seaweed-Based Biopolymer Films

et al. 2020

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Neem leaves extract was incorporated into the matrix of seaweed biopolymer, and the seaweed-neem biocomposite films were irradiated with various doses of gamma irradiation (0.5, 1.5, 2.5, 3.5, and 4.5 kGy). The physical, barrier, antimicrobial, and mechanical properties of the films were studied. The incorporation of 5% w/w neem leaves extract into a seaweed-based film, and gamma irradiation dose of 2.5 kGy was most effective for improved properties of the film. The results showed that the interfacial interaction of the seaweed-neem improved with physical changes in colour and opacity. The water solubility, moisture content, and water vapour permeability and biodegradability rate of the film reduced. The contact angle values increased, which was interpreted as improved hydrophobicity. The tensile strength and modulus of the films increased, while the elongation of the composite films decreased compared to the control film. The film’s antimicrobial activities against bacteria were improved. Thus, neem leaves extract in combination with the application of gamma irradiation enhanced the performance properties of the film that has potential as packaging material.

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“…They show high biocompatibility and safety for drug delivery applications [55]. Other carbohydrates, e.g., gum polysaccharides and hyaluronic acids (HA), with molecular weights higher than the previous saccharides, e.g., maltose, can be used in the matrix of MNs or as particles embedded in MNs [56][57][58][59]. Proteins, synthetic polymers, and polysaccharides exhibit high biocompatibility and degradability.…”

Section: Methodsmentioning

confidence: 99%

Progress in Microneedle-Mediated Protein Delivery

Jamaledin

Natale

Onesto

et al. 2020

JCM

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The growing demand for patient-compliance therapies in recent years has led to the development of transdermal drug delivery, which possesses several advantages compared with conventional methods. Delivering protein through the skin by transdermal patches is extremely difficult due to the presence of the stratum corneum which restricts the application to lipophilic drugs with relatively low molecular weight. To overcome these limitations, microneedle (MN) patches, consisting of micro/miniature-sized needles, are a promising tool to perforate the stratum corneum and to release drugs and proteins into the dermis following a non-invasive route. This review investigates the fabrication methods, protein delivery, and translational considerations for the industrial scaling-up of polymeric MNs for dermal protein delivery.

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Antimicrobial gum bio-based nanocomposites and their industrial and biomedical applications

Abstract: Schematic illustration of the gum biobased materials in biomedical and industrial applications.

Cited by 88 publications

References 152 publications

Toward Regulatory Effects of Curcumin on Transforming Growth Factor-Beta Across Different Diseases: A Review

Toward Regulatory Effects of Curcumin on Transforming Growth Factor-Beta Across Different Diseases: A Review

Extracted Compounds from Neem Leaves as Antimicrobial Agent on the Physico-Chemical Properties of Seaweed-Based Biopolymer Films

Progress in Microneedle-Mediated Protein Delivery

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