Antimicrobial efficacy of granulysin‐derived synthetic peptides in acne vulgaris

Lim, Heesun; Chun, Seung-Min; Soung, Min‐Gyu; Kim, Jenny; Kim, Seong‐Jin

doi:10.1111/ijd.12756

Cited by 16 publications

(15 citation statements)

References 24 publications

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“…In this context, hBD‐2, LL‐37, S100A7 and RNase 7 individually or synergistically kill P. acnes . Furthermore, granulysin displays potent antimicrobial activity against P. acnes . Topical application of a granulysin‐derived peptide in patients with acne vulgaris reduced the number of pustules, and this peptide suppressed P. acnes ‐mediated cytokine release .…”

Section: Role Of Amps/hdps In Human Skin Diseasesmentioning

confidence: 99%

“…Furthermore, granulysin displays potent antimicrobial activity against P. acnes . Topical application of a granulysin‐derived peptide in patients with acne vulgaris reduced the number of pustules, and this peptide suppressed P. acnes ‐mediated cytokine release . Given that P. acnes causes inflammation in acne and that AMPs/HDPs exhibit killing activity against P. acnes and suppress inflammatory responses mediated by bacterial products, these molecules are potential candidates in the prevention and treatment of acne vulgaris.…”

Section: Role Of Amps/hdps In Human Skin Diseasesmentioning

confidence: 99%

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Friends or Foes? Host defense (antimicrobial) peptides and proteins in human skin diseases

Niyonsaba

Kiatsurayanon

Chieosilapatham

et al. 2017

Experimental Dermatology

138

135

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Host defense peptides/proteins (HDPs), also known as antimicrobial peptides/proteins (AMPs), are key molecules in the cutaneous innate immune system. AMPs/HDPs historically exhibit broad-spectrum killing activity against bacteria, enveloped viruses, fungi and several parasites. Recently, AMPs/HDPs were shown to have important biological functions, including inducing cell proliferation, migration and differentiation; regulating inflammatory responses; controlling the production of various cytokines/ chemokines; promoting wound healing; and improving skin barrier function. Despite the fact that AMPs/HDPs protect our body, several studies have hypothesized that these molecules actively contribute to the pathogenesis of various skin diseases. For example, AMPs/HDPs play crucial roles in the pathological processes of psoriasis, atopic dermatitis, rosacea, acne vulgaris, systemic lupus erythematosus and systemic sclerosis. Thus, AMPs/HDPs may be a double-edged sword, promoting cutaneous immunity while simultaneously initiating the pathogenesis of some skin disorders. This review will describe the most common skin-derived AMPs/HDPs (defensins, cathelicidins, S100 proteins, ribonucleases and dermcidin) and discuss the biology and both the positive and negative aspects of these AMPs/HDPs in skin inflammatory/infectious diseases. Understanding the regulation, functions and mechanisms of AMPs/HDPs may offer new therapeutic opportunities in the treatment of various skin disorders. K E Y W O R D Santimicrobial agent, infection, inflammation, skin immunity, therapeutic agent

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Section: Role Of Amps/hdps In Human Skin Diseasesmentioning

confidence: 99%

Section: Role Of Amps/hdps In Human Skin Diseasesmentioning

confidence: 99%

Friends or Foes? Host defense (antimicrobial) peptides and proteins in human skin diseases

Niyonsaba

Kiatsurayanon

Chieosilapatham

et al. 2017

Experimental Dermatology

138

135

View full text Add to dashboard Cite

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“…Antimicrobial peptides (AMP) are implicated in the development of acne vulgaris. AMPs may be protective by acting against Propionibacterium acnes or pro‐inflammatory acting as signaling molecules For example, Lim, Chun, Soung, Kim, and Kim () showed that increase of Granulysin human AMP was associated with a significant reduction in the clinical grade of acne based on the Korean Acne Grading System. The anti‐inflammatory properties of isotretinoin are thought to be due to the effects on monocyte chemotaxis (Seguin‐Devaux et al, ), downregulation of Toll‐like receptor 2 (TLR2) expression, inhibition of Th17, and promotion of regulatory T cell (Treg) responses.…”

Section: Comparison Of Dermcidin Level Between the Studied Groupsmentioning

confidence: 99%

The effect of continuous high versus low dose oral isotretinoin regimens on dermcidin expression in patients with moderate to severe acne vulgaris

Ragab

Omar

Collier

et al. 2018

Dermatologic Therapy

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The continuous low dose (LD) isotretinoin is frequently used in the treatment regimen for acne vulgaris. However, data about its antimicrobial are lacking. The present study aimed to investigate dermcidin expression and the effects of low and conventional dose isotretinoin on its expression in acne vulgaris patients. Skin dermcidin expression was investigated in 30 patients with moderate–severe acne vulgaris and 15 healthy control subjects using ELISA. 15 patients were given continuous low‐dose isotretinoin (20 mg/day) and the other 15 given the conventional high dose (0.5 mg/kg/day). Skin biopsies were taken at the start of the study and 6 months later. Dermcidin was significantly lower in acne vulgaris patients (p < .001). Both isotretinoin regimens significantly raised dermcidin levels compared to pre‐treatment values (p < .001). Relapse after 12 months was not statistically different among the two isotretinoin regimens (p = .464). Pretreatment global acne grading system score of 28.6 ± 6.4 was reduced to 6 ± 6.1 following isotretinoin treatment (p < .001). Relapse was significantly related to posttreatment dermcidin levels (p = .017). Dermcidin expression is reduced in acne vulgaris. Conventional and LD isotretinoin regimens are associated with increased dermcidin expression.

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“…Current standard treatments are accompanied by severe side effects and low efficiency in many acne patients (Ryu et al, 2015 ). Thus, C. acnes represents an excellent target for the treatment with antimicrobial peptides due to their dual-immunomodulatory and antimicrobial activity and low resistance rate (Harder et al, 2013 ; Lim et al, 2015 ). AMPs were found to inhibit growth of C. acnes and release of pro-inflammatory cytokines in peripheral blood mononuclear cells while increasing anti-inflammatory cytokines (Popovic et al, 2012 ).…”

Section: Amps For the Treatment Of Sstismentioning

confidence: 99%

Antimicrobial Peptides and Their Therapeutic Potential for Bacterial Skin Infections and Wounds

Brandenburg²,

2018

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Alarming data about increasing resistance to conventional antibiotics are reported, while at the same time the development of new antibiotics is stagnating. Skin and soft tissue infections (SSTIs) are mainly caused by the so called ESKAPE pathogens (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter species) which belong to the most recalcitrant bacteria and are resistant to almost all common antibiotics. S. aureus and P. aeruginosa are the most frequent pathogens isolated from chronic wounds and increasing resistance to topical antibiotics has become a major issue. Therefore, new treatment options are urgently needed. In recent years, research focused on the development of synthetic antimicrobial peptides (AMPs) with lower toxicity and improved activity compared to their endogenous counterparts. AMPs appear to be promising therapeutic options for the treatment of SSTIs and wounds as they show a broad spectrum of antimicrobial activity, low resistance rates and display pivotal immunomodulatory as well as wound healing promoting activities such as induction of cell migration and proliferation and angiogenesis. In this review, we evaluate the potential of AMPs for the treatment of bacterial SSTIs and wounds and provide an overview of the mechanisms of actions of AMPs that contribute to combat skin infections and to improve wound healing. Bacteria growing in biofilms are more resistant to conventional antibiotics than their planktonic counterparts due to limited biofilm penetration and distinct metabolic and physiological functions, and often result in chronification of infections and wounds. Thus, we further discuss the feasibility of AMPs as anti-biofilm agents. Finally, we highlight perspectives for future therapies and which issues remain to bring AMPs successfully to the market.

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Antimicrobial efficacy of granulysin‐derived synthetic peptides in acne vulgaris

Abstract: Synthesized GDP shows strong antimicrobial activity against P. acnes in vitro. The clinical improvement observed suggests a topical formulation containing the GDP has therapeutic potential for the improvement of inflammatory-type acne vulgaris by its antimicrobial activity.

Cited by 16 publications

References 24 publications

Friends or Foes? Host defense (antimicrobial) peptides and proteins in human skin diseases

Friends or Foes? Host defense (antimicrobial) peptides and proteins in human skin diseases

The effect of continuous high versus low dose oral isotretinoin regimens on dermcidin expression in patients with moderate to severe acne vulgaris

Antimicrobial Peptides and Their Therapeutic Potential for Bacterial Skin Infections and Wounds

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