Antimicrobial efficacy of Egyptian Eremina desertorum and Helix aspersa snail mucus with a novel approach to their anti-inflammatory and wound healing potencies

El-Zawawy, Nessma; Mona, Mahy M.

doi:10.1038/s41598-021-03664-3

Cited by 21 publications

(22 citation statements)

References 36 publications

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“…Formerly, the slime of Helix aspersa snails was confirmed to ameliorate colon inflammation as it contained anti-inflammatory and antioxidant components [10]. Recently, El-Zawawy and Mona [32] confirmed that mucous extracts from E. desertorum snails have higher biological effects compared to H. aspersa, which recommended to be used for human therapies.…”

Section: Discussionmentioning

confidence: 99%

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The antioxidant and anti-inflammatory effects of Eremina desertorum snail mucin on experimentally induced intestinal inflammation and testicular damage

et al. 2022

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Eremina desertorum snail mucin antioxidant and anti-inflammatory effects were investigated against carbon tetrachloride (CCl4)-intestinal inflammation and testes damage. Male albino mice were intraperitoneally injected with 0.5 ml/kg b.wt of 40% CCl4, twice a week for 8 weeks. The treated groups were treated orally with mucin (after 8 weeks of CCl4 intoxication, twice a week for four weeks). CCl4causedsignificant increases in C-reactive protein, lipid peroxidation, interlukine-2 levels and caspase-3, while decreasing the total proteins levels, activities of catalase (CAT),superoxide dismutase (SOD), and glutathione reductase (GSH) contents, testosterone and 17β estradiol levels compared with the control mice. The improvements of these parameters occurred after treatment with E. desertorum mucin, where all the biochemical measurements tended to restore to the normal values. Histopathologically, CCl4 caused ulceration in the columnar mucin secreting cells that lined the ileal mucosa, partial loss of goblet cells, abnormal villous/crypt ratio, and submucosal infiltrate of the inflammatory cells. Also, sections of testis showed alterations in the developmental spermatogenic arrangement of the same seminiferous tubules, with no spermatozoa in the center. Improvements in these architectures occurred after administration of mucin, where sections showed almost normal histological structure. In conclusion, E. desertorum mucin could be used as a supplementary material as it has antioxidant and anti-inflammatory effects; besides it has low cost.

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Section: Discussionmentioning

confidence: 99%

“…They reasoned these damages to the metabolism of CCl4 and lipid peroxidation. Also, many researches confirmed the anti-oxidant and the anti-cancer activities of E. desertorum snails´ mucin and concluded that it could be used as natural therapeutic agents against colon and liver cancers [10,32].…”

Section: Discussionmentioning

confidence: 99%

The antioxidant and anti-inflammatory effects of Eremina desertorum snail mucin on experimentally induced intestinal inflammation and testicular damage

et al. 2022

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“…Sardela et al [ 47 ] discussed how the water effluent from the tank may provide valuable information about the metabolites as a model of fish metabolism. According to the National Center for Biotechnology Information [ 48 ], the 4-trimethylsilyl metabolite has been shown to be attributable to antimicrobial and anti-inflammatory activities [ 49 ]. However, this research could not demonstrate that the origin of this metabolite may be related to fish metabolism by supplementation with vitamin C. Nevertheless, the data from this study showed minor DNA damage in the tilapia when they received a greater amount of the herbal mix as a source of vitamin C. Thus, the current research provides new evidence for a probable metabolite with an anti-inflammatory role.…”

Section: Discussionmentioning

confidence: 99%

Herbal Vitamin C Prevents DNA Oxidation and Modifies the Metabolomic Water Profile of Tilapia (Oreochromis spp.)

Villanueva

Espinosa-Reyes

Flores-Ramírez

et al. 2022

Life

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This experiment aimed to evaluate the effects of herbal vitamin C at different levels on tilapia (Oreochromis spp.) growth, potential DNA damage, and the metabolomic profile of water effluent. Forty-five tilapias were housed in separate plastic tanks (80 L), and these were randomly assigned to three treatments: (a) a commercial diet (CD) only; (Nutripec Purina®); (b) the commercial diet plus 250 mg of herbal vitamin C (HVC)/kg (CD250); and (c) the commercial diet plus 500 mg of HVC/kg (CD500). Biometric measurements were taken each week, blood samples were collected from the caudal vein on the final day, and water effluent was taken each week and immediately frozen (−80 °C) until further analysis (gas chromatography/mass spectrometry (GC/MS) systems). Data were completely randomized with a 2 × 2 factorial arrangement of treatments. Upon including herbal vitamin C, the final BW (p = 0.05) and BWG (p = 0.06) increased linearly. Herbal vitamin C decreases DNA damage (p ≥ 0.05). PLS-DA showed a 41.6% variation between treatments in the water samples. Fifteen metabolites had the best association between treatments, with a stronger correlation with CD500. Herbal vitamin C could improve fish performance, prevent DNA damage, and influence changes in the metabolomic profile of the water.

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“…Snail secretion, the principal ingredient, contains several bioactive compounds, including achacin, that possess antimicrobial and anti-inflammatory effects. 5,6 Another attractive ingredient is Calendula officinalis (C. officialnalis), also known as marigold. In previous in vitro studies, this agent also exhibits similar properties, such as anti-inflammatory and antimicrobial activity, which may synergistically enhance the anti-acne effect.…”

Section: Introductionmentioning

confidence: 99%

“…Natural ingredients in cosmeceutical products continue to outpace other compounds in recent years. Snail secretion, the principal ingredient, contains several bioactive compounds, including achacin, that possess antimicrobial and anti‐inflammatory effects 5,6 . Another attractive ingredient is Calendula officinalis ( C. officialnalis ), also known as marigold.…”

Section: Introductionmentioning

confidence: 99%

Efficacy and safety of a facial serum containing snail secretion filtrate, Calendula officinalis, and Glycyrrhiza glaba root extract in the treatment of maskne: A randomized placebo‐controlled study

Puaratanaarunkon

Washrawirul

Chuenboonngarm

et al. 2022

J of Cosmetic Dermatology

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Introduction During the ongoing COVID‐19 outbreak, face mask use has increased and became a part of our daily lives. While wearing, prolonged contact time and microenvironmental change profoundly lead to an acne flare‐up, defined as “maskne.” Aims We aimed to assess the efficacy and safety of snail secretion filtrate, Calendula officinalis, and Glycyrrhiza glaba root extract combination serum (SCGS) in treating the maskne. Methods This was a randomized, double‐blind, placebo‐controlled trial study. This study enrolled 66 participants with mild‐to‐moderate maskne. The SCGS and placebo were randomly assigned for participants to use twice daily for 12 weeks. Percentage change of acne lesion count, acne severity by Investigator Global Evaluation Acne (IGEA), sebum levels, corneometry levels, transepidermal water loss (TEWL), erythema score by Visia®, and adverse events were evaluated 4‐weekly at baseline to Week 12. At Week 12, all participants evaluated their satisfaction scores using a 10‐point visual analog scale (VAS). Results In the mask‐covered area, the percent reduction in inflammatory acne lesions from the treatment group was significantly greater than the placebo group at all time points (coefficient of percentage change of inflammatory lesions = −33.89 [95% CI −65.24, −2.53]; p = 0.03). Also, a subgroup analysis with participants using concurrent acne treatments revealed similar results (12 participants, coefficient = −50.30 [95% −88.65, −11.95]; p = 0.01). However, there were no significant differences in non‐inflammatory lesions, all skin biophysics, and VAS between groups. Adverse events were mild and occurred in a few cases in both groups. Conclusions The SCGS could significantly improve inflammatory acne lesions and had a favorable tolerability profile, suggesting its role as an adjunctive treatment in maskne.

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Antimicrobial efficacy of Egyptian Eremina desertorum and Helix aspersa snail mucus with a novel approach to their anti-inflammatory and wound healing potencies

Cited by 21 publications

References 36 publications

The antioxidant and anti-inflammatory effects of Eremina desertorum snail mucin on experimentally induced intestinal inflammation and testicular damage

The antioxidant and anti-inflammatory effects of Eremina desertorum snail mucin on experimentally induced intestinal inflammation and testicular damage

Herbal Vitamin C Prevents DNA Oxidation and Modifies the Metabolomic Water Profile of Tilapia (Oreochromis spp.)

Efficacy and safety of a facial serum containing snail secretion filtrate, Calendula officinalis, and Glycyrrhiza glaba root extract in the treatment of maskne: A randomized placebo‐controlled study

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