Antimicrobial Effect of 7-O-Butylnaringenin, a Novel Flavonoid, and Various Natural Flavonoids against Helicobacter pylori Strains

Moon, Sun Hee; Lee, Jae Hoon; Kim, Kee‐Tae; Park, Yong-Sun; Nah, Seung‐Yeol; Ahn, Dong U.; Paik, Hyun‐Dong

doi:10.3390/ijerph10115459

Cited by 37 publications

(32 citation statements)

References 26 publications

(30 reference statements)

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“…20 Studies have shown the antimicrobial effect of HSP especially against bacterial strains and came out with promising results. 21 In the present study, HSP shows antifungal activity against Candida species i.e., C. albicans (only in higher concentration) and C. tropicalis. The HSP treatment also shows inhibitory effect against Malassezia furfur.…”

Section: Discussionsupporting

confidence: 45%

In vitro Antifungal Effects of Hesperetin and Silibinin

Gowtham¹,

Yousuf²,

Ezhilarasan³

et al. 2018

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Background:Increasing resistance of microorganisms against available antimicrobial agents is of major concern among scientists and clinicians worldwide. To overcome the resistance and other drawbacks of the current antimicrobial drugs and to obtain more efficacious drugs, an antimicrobial drug having a novel mode of action should be developed. The flavonoid compounds have demonstrated for their therapeutic potential as antimicrobial agents previously. Aim: To evaluate the antifungal efficacy of plant derived compounds such as hesperetin (HSP) and silibinin (SBN) compounds in vitro. Materials and Methods: In this study, we evaluated the antifungal effect of two plant derived flavonoid compounds i.e., SBN and HSP against Candida albicans, Candida tropicalis, Malassezia furfur, Aspergillus niger, Penicillium oxalicum. The disk diffusion test was performed to test the antifungal effect of HSP and SBN with three different concentrations i.e., 15, 20, 25 mg/ml of HSP and SBN. The antifungal efficacy was studied for 72 h. Results: Our results indicate that SBN has significant antifungal effect than that of HSP. The high sensitivity of these compounds was found against C. albicans, C. tropicalis. Conclusion: These drugs could be good candidate to combine with regular antimicrobial agents.

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Section: Discussionsupporting

confidence: 45%

In vitro Antifungal Effects of Hesperetin and Silibinin

Gowtham¹,

Yousuf²,

Ezhilarasan³

et al. 2018

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“…Recently, Moon et al . evaluated and compared the antimicrobial effects of 9 flavonoids (two flavonols, three flavones and three flavanones) on 3 different Helicobacter pylori strains (26695, 51, and SS1). Among the 9 samples, hesperetin and naringenin showed the strongest antimicrobial effect and thus were compared to 7‐ O ‐butylnaringenin, a new flavanone modified from naringenin.…”

Section: Biological Properties Of Citrus Flavanonesmentioning

confidence: 92%

Flavanones: Citrus phytochemical with health‐promoting properties

et al. 2017

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Citrus fruit and juices represent one of the main sources of compounds with a high potential for health promoting properties. Among these compounds, flavanones (such as hesperetin, naringenin, eriodictyol, isosakuranetin, and their respective glycosides), which occur in quantities ranging from ∼180 to 740 mg/L (depending on the Citrus species and cultivar) are responsible for many biological activities. These compounds support and enhance the body's defenses against oxidative stress and help the organism in the prevention of cardiovascular diseases, atherosclerosis, and cancer. Moreover, among other properties, they also show anti-inflammatory, antiviral, and antimicrobial activities. This review analyzes the biochemistry, pharmacology, and biology of Citrus flavanones, emphasizing the occurrence in Citrus fruits and juices and their bioavailability, structure-function correlations and ability to modulate signal cascades both in vitro and in vivo. © 2017 BioFactors, 43(4):495-506, 2017.

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“…In a set of eleven studies [45][46][47][48][49][50][51][52][53][54][55] determining an activity and morphological effect of plant extracts and plant-derived compounds on H. pylori, four of them reported a bacteriostatic activity [45][46][47][48] and six indicated a bactericidal effect [49][50][51][52][53][54] of the tested compounds. In one case, the use of this classification was avoided [55].…”

Section: Plant Extracts and Plant-derived Compoundsmentioning

confidence: 99%

“…Among the four studies [45][46][47][48] suggesting the bacteriostatic effect on H. pylori, in two a dominance of spherical forms was noted [46,48], in one the stimulation was low (33% after 48 h) [45], while in the last the production of spherical forms was not observed [47]. From these, an ability of the substance to completely reduce the viability was only demonstrated in the Ali et al study [46], which took place after 6 h and 9 h for 2x MBC and MBC, respectively.…”

Section: Plant Extracts and Plant-derived Compoundsmentioning

confidence: 99%

Transformation of Helicobacter pylori into Coccoid Forms as a Challenge for Research Determining Activity of Antimicrobial Substances

Krzyżek

Grande

2020

Pathogens

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Morphological variability is one of the phenotypic features related to adaptation of microorganisms to stressful environmental conditions and increased tolerance to antimicrobial substances. Helicobacter pylori, a gastric mucosal pathogen, is characterized by a high heterogeneity and an ability to transform from a spiral to a coccoid form. The presence of the coccoid form is associated with the capacity to avoid immune system detection and to promote therapeutic failures. For this reason, it seems that the investigation for new, alternative methods combating H. pylori should include research of coccoid forms of this pathogen. The current review aimed at collecting information about the activity of antibacterial substances against H. pylori in the context of the morphological variability of this bacterium. The collected data was discussed in terms of the type of substances used, applied research techniques, and interpretation of results. The review was extended by a polemic on the limitations in determining the viability of coccoid H. pylori forms. Finally, recommendations which can help in future research aiming to find new compounds with a potential to eradicate H. pylori have been formulated.

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Antimicrobial Effect of 7-O-Butylnaringenin, a Novel Flavonoid, and Various Natural Flavonoids against Helicobacter pylori Strains

Cited by 37 publications

References 26 publications

In vitro Antifungal Effects of Hesperetin and Silibinin

In vitro Antifungal Effects of Hesperetin and Silibinin

Flavanones: Citrus phytochemical with health‐promoting properties

Transformation of Helicobacter pylori into Coccoid Forms as a Challenge for Research Determining Activity of Antimicrobial Substances

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