Antimicrobial Drugs and Infections in Ambulatory Patients: Some Problems and Perspectives

McHenry, Martin C.; Weinstein, Allan J.

doi:10.1016/s0025-7125(16)31222-6

Cited by 12 publications

(5 citation statements)

References 95 publications

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“…However some authors are of the opinion that the incidence of post-operative infections after SRIMTM (1-5 %) is too low to justify routine antibiotics [11]. The blind use of antimicrobials can result in adverse outcomes, and there is a general trend to overprescribe antimicrobials [12]. Curran et al [13], in their series, compared antibiotic therapy with no antibiotic therapy and found no difference regarding post-operative infections.…”

Section: Resultsmentioning

confidence: 99%

Is Post-Operative Antibiotic Therapy Justified for Surgical Removal of Mandibular Third Molar? A Comparative Study

Sane

Gadre

Chandan

et al. 2013

J. Maxillofac. Oral Surg.

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Surgical removal of impacted mandibular third molar (SRIMTM) is the most common procedure performed in oral and maxillofacial surgery. In the literature, many complications associated with lower third molar removal are described such as pain, swelling, trismus, infection, inflammation, and nerve damage. Antibiotics are routinely used either pre-operatively or post-operatively to reduce the chances of surgical site infection (SSI). However routine use of antibiotics for SRIMTM is still controversial. For antibiotics to be effective in reducing post-operative infective complications, the time of administration is very important. Adequate serum concentration of antibiotic must be achieved prior to the procedure. In a developing country like India, antibiotics are routinely prescribed post-operatively. The current study is designed to evaluate the efficacy of post-operative prophylactic antibiotic in SRIMTM.

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Section: Resultsmentioning

confidence: 99%

Is Post-Operative Antibiotic Therapy Justified for Surgical Removal of Mandibular Third Molar? A Comparative Study

Sane

Gadre

Chandan

et al. 2013

J. Maxillofac. Oral Surg.

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“…Some of the risks of antibiotic therapy include the toxicity of the substance itself, allergic reactions, secondary infections, and, most commonly, the development of resistant organisms. In general, clinicians show a tendency to overprescribe antibiotics and medications [ 19 ]. Prescription of systemic antibiotics is common after mandibular third molar surgery.…”

Section: Discussionmentioning

confidence: 99%

Comparison of the Postoperative Effects of Local Antibiotic versus Systemic Antibiotic with the Use of Platelet-Rich Fibrin on Impacted Mandibular Third Molar Surgery: A Randomized Split-Mouth Study

Donmezer¹,

Bilginaylar

2021

BioMed Research International

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The surgery of the impacted mandibular third molar is the most frequent procedure in dentistry. The prescription of systemic antibiotics after the third molar extraction is widespread among dentists, but this is still argumentative. This study is aimed at evaluating the postoperative effects of local antibiotic mixed with platelet-rich fibrin (PRF) and a postoperative systemic antibiotic prescribed for mandibular third molar surgery. The study included 75 patients divided into a control and 4 test groups ( n = 15 ). In the control group, only PRF was placed into the extracted socket, and no antibiotic was prescribed. In the first and third groups, PRF was applied to the socket; penicillin and clindamycin were prescribed as oral medications, respectively. In the second and fourth groups, only PRF combined with penicillin and clindamycin was applied into the socket, respectively. The outcome variables were pain, swelling, analgesic intake, and trismus. These variables were also assessed based on the first, second, third, and seventh days following the operation. Unpaired Student’s t -test and Mann–Whitney U test were used for analysis. There were significant differences in the total VAS pain scores between the control and group 3 ( p < 0.05 ), groups 1 and 2 ( p < 0.01 ), and group 4 ( p < 0.001 ) in ascending order. For analgesic intake, there was no significant difference for group 1 ( p > 0.05 ). However, there were statistical differences between the control group and groups 2 and 3 ( p < 0.01 ) and group 4 ( p < 0.001 ). Trismus and swelling did not differ among the groups ( p > 0.05 ). This study showed that the effects of local and systemic antibiotics with the use of PRF reduced postoperative outcomes. Moreover, local antibiotics with PRF may be a viable method to avoid the possible side effects of systemic antibiotics.

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“…The blind use of antimicrobials can result in adverse outcomes, and there is a general trend to overprescribe antimicrobials [16]. The risks of indiscriminate prescribing include development of resistant organisms, secondary infection, toxicity, and the development of allergic reactions [17].…”

Section: Discussionmentioning

confidence: 99%

Efficacy of Single Dose Azithromycin as Prophylactic Antibiotic in Surgical Removal of Mandibular Third Molars: A Clinical Study

Sane

Gadre

Chandan

et al. 2013

J. Maxillofac. Oral Surg.

View full text Add to dashboard Cite

show abstract

Antimicrobial Drugs and Infections in Ambulatory Patients: Some Problems and Perspectives

Cited by 12 publications

References 95 publications

Is Post-Operative Antibiotic Therapy Justified for Surgical Removal of Mandibular Third Molar? A Comparative Study

Is Post-Operative Antibiotic Therapy Justified for Surgical Removal of Mandibular Third Molar? A Comparative Study

Comparison of the Postoperative Effects of Local Antibiotic versus Systemic Antibiotic with the Use of Platelet-Rich Fibrin on Impacted Mandibular Third Molar Surgery: A Randomized Split-Mouth Study

Efficacy of Single Dose Azithromycin as Prophylactic Antibiotic in Surgical Removal of Mandibular Third Molars: A Clinical Study

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