Antimicrobial diterpenes fromPolyalthia longifolia var.pendulla (Annonaceae)

Rashid, Mohammad A.; Hossain, Md. Alamgir; Hasan, Choudhury M.; Reza, Selim

doi:10.1002/(sici)1099-1573(199602)10:1<79::aid-ptr774>3.0.co;2-d

Cited by 25 publications

(14 citation statements)

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“…1 and Table 1). This compound has been isolated as the cytotoxic and antibacterial active ingredient (Ma et al, 1994;Rashid et al, 1996;Hagiwara et al, 1995). However, it has not been reported to have antimalarial activity.…”

Section: Resultsmentioning

confidence: 99%

Screening of Thai medicinal plant extracts and their active constituents forIn Vitro antimalarial activity

et al. 2006

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To discover antimalarial substances from plants cultivated in Thailand 80%-EtOH extracts from selected plants were screened for in vitro antimalarial activity against the drug resistant K1 strain of Plasmodium falciparum. In total, 86 Thai medicinal plant samples representing 48 species from 35 genera in 16 families were screened and two species (Polyalthia viridis and Goniothalamus marcanii) were found to show notable antimalarial activity (IC50: 10.0 and 6.3 microg/mL). Marcanine A and 16-hydroxycleroda-3,13(14)Z-dien-15,16-olide were identified as the respective major active constituents in P. viridis and G. marcanii, respectively.

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Section: Resultsmentioning

confidence: 99%

Screening of Thai medicinal plant extracts and their active constituents forIn Vitro antimalarial activity

et al. 2006

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“…In the traditional system of medicine, the plants are used as a bitter tonic, abortifacient, febrifuge, a cure for scorpion strings, hypertension and as a respiratory stimulant [3]. Biological evaluations of Polyalthia species have shown them to exhibit cytotoxic, antimicrobial [4,5], anticancer [6], antimalarial, antimycobacterial [7,8], and HIV-inhibitory [9] activities. A recent and comprehensive review of the constituents of Polyalthia species [10] has revealed that although P. simiarum has never been subjected to chemical studies, previous investigations on Polyalthia species resulted in the isolation of various types of secondary metabolites, including alkaloids, acetogenins, clerodane diterpenes, triterpenes, benzopyran derivatives, flavonoids, and polyacetylenes.…”

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confidence: 99%

An Unusual Bisnor-clerodane Diterpenoid from Polyalthia Simiarum

Kabir

Rahman

Chowdhury

et al. 2010

Natural Product Communications

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The stem bark of Polyalthia simiarum has yielded a new bisnor-type clerodane diterpenoid, 2-oxo-14,15-bisnor-3,11Ekolavadien-13-one (1), and three previously known clerodane derivatives, kolavenic acid (2), 16β-hydroxycleroda-3,13(14)Zdien-15,16-olide (3), and 16-oxocleroda-3,13(14)E-dien-15-oic acid (4). The structures of these compounds were unambiguously determined by extensive NMR studies as well as by comparison with related compounds. Till now this is the second report of the occurrence of any unusual C-18 clerodane diterpenoid from nature. The crude light petroleum extract and the purified compound 3 demonstrated moderate free radical scavenging activity with IC 50 values of 21.5 and 23.5 μg/mL, respectively.

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“…Ichino et al (2006) also reported antiplasmodial activity (IC 50 11.32 mM) of 16-hydroxycleroda-3,13(14)-dien-16,15-olide (1) which was isolated from the ethanol extract of P. viridis leaves. Some other bioactivities, reported of compound 1 together with 2 and 3, are anti-tumor, antimicrobial, antileishmanial, anti-inflammatory, antidyslipidemic and antioxidant properties (Ma et al, 1994;Hagiwara et al, 1995;Rashid et al, 1996;Sashidhara et al, 2009;Katkar et al, 2010). This is however, the first report of the antiplasmodial activity of compounds 2 and 3, with compound 2 (16-oxocleroda-3,13(14)Edien-15-oic acid) being the most active (IC 50 9.59 mM).…”

Section: Resultsmentioning

confidence: 99%