An Unusual Bisnor-clerodane Diterpenoid from <i>Polyalthia Simiarum</i>

Kabir, Selina; Rahman, Mohammad Shafiqur; Chowdhury, A. M. Sarwaruddin; Hasan, Choudhury M.; Rashid, Mohammad A.

doi:10.1177/1934578x1000501005

Cited by 8 publications

(5 citation statements)

References 16 publications

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“…Plant extracts and natural products are sources of anti-oxidative agents. As reported (Figure 2), flavonoids (61)(62)(63) [54,55] and proanthocyanidins [56] extracted from P. longifolia leaves and clerodane diterpenes (47) isolated from stem bark of P. simiarum [57] as well as stem bark of P. longifolia extracts [58] displayed anti-oxidative activities, as detected by the DPPH method and enzymatic activity assay. Oyeyemi et al (2020) demonstrated that P. longifolia aqueous and methanolic leaf extracts present the prophylactic and the curative activities against cadmium (a major environmental pollutant)-induced hepatotoxicity by relieving the oxidative stress in rats [59].…”

Section: Anti-oxidant Phytochemicals In Polyalthiasupporting

confidence: 57%

Phytochemicals from Polyalthia Species: Potential and Implication on Anti-Oxidant, Anti-Inflammatory, Anti-Cancer, and Chemoprevention Activities

2021

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Polyalthia belong to the Annonaceae family and are a type of evergreen tree distributed across many tropical and subtropical regions. Polyalthia species have been used long term as indigenous medicine to treat certain diseases, including fever, diabetes, infection, digestive disease, etc. Recent studies have demonstrated that not only crude extracts but also the isolated pure compounds exhibit various pharmacological activities, such as anti-oxidant, anti-microbial, anti-tumor, anti-cancer, etc. It is known that the initiation of cancer usually takes several years and is related to unhealthy lifestyle, as well as dietary and environmental factors, such as stress, toxins and smoking. In fact, natural or synthetic substances have been used as cancer chemoprevention to delay, impede, or even stop cancer growing. This review is an attempt to collect current available phytochemicals from Polyalthia species, which exhibit anti-cancer potentials for chemoprevention purposes, providing directions for further research on the interesting agents and possible clinical applications.

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Section: Anti-oxidant Phytochemicals In Polyalthiasupporting

confidence: 57%

Phytochemicals from Polyalthia Species: Potential and Implication on Anti-Oxidant, Anti-Inflammatory, Anti-Cancer, and Chemoprevention Activities

2021

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“…163 Isolated from several different plant species, compounds 1086–1089 are unusual 14,15-bisnor clerodanes with a C-4/C-5 double bond, 44,79,219,391 and compounds 1090–1096 are 13,14,15,16-tetranor-clerodanes. Among the latter tetranor-clerodanes, C-12 is present as a free carboxylic acid ( e.g.…”

Section: Structure Classifications and Sources Of Clerodane Diterpmentioning

confidence: 99%

Clerodane diterpenes: sources, structures, and biological activities

2016

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The clerodane diterpenoids are a widespread class of secondary metabolites and have been found in several hundreds of plant species from various families and in organisms from other taxonomic groups. These substances have attracted interest in recent years due to their notable biological activities, particularly insect antifeedant properties. In addition, the major active clerodanes of Salvia divinorum can be used as novel opioid receptor probes, allowing greater insight into opioid receptor-mediated phenomena, as well as opening additional areas for chemical investigation. This article provides extensive coverage of naturally occurring clerodane diterpenes discovered from 1990 until 2015, and follows up on the 1992 review by Merritt and Ley in this same journal. The distribution, chemotaxonomic significance, chemical structures, and biological activities of clerodane diterpenes are summarized. In the cases where sufficient information is available, structure activity relationship (SAR) correlations and mode of action of active clerodanes have been presented.

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“…Polyalthia species have a wide distribution since they were found in Asia, Africa, Australia, and New Zealand [1] . The plants of this genus have been considered as a medicinally important resource because they have bioactive compounds type clerodane diterpenoids [2–4] . Polyalthia plants are also a rich reservoir of antimicrobial essential oils [5–7] .…”

Section: Introductionmentioning

confidence: 99%

Essential Oils of Polyalthia suberosa Leaf and Twig and Their Cytotoxic and Antimicrobial Activities

Son

Tuan²,

Thuy³

et al. 2021

Chemistry & Biodiversity

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Essential oils from the leaf and twig of Polyalthia suberosa (Roxb.) Thwaites were analyzed using GC/MS/FID. A total of sixty‐three constituents were namely identified accounting for 96.03 and 94.12 % in the hydrodistilled oils of the leaf and twig, respectively. Monoterpenes, monoterpenoids, sesquiterpenes, and sesquiterpenoids were characteristic derivatives of P. suberosa essential oils. Sesquiterpenes bicyclogermacrene (26.26 %) and (E)‐caryophyllene (7.79 %), and monoterpene β‐pinene (12.71 %) were the major constituents of the leaf oil. Sesquiterpenes (E)‐caryophyllene (17.17 %) and α‐humulene (9.55 %), sesquiterpenoid caryophyllene oxide (9.41 %), and monoterpenes camphene (8.16 %) and tricyclene (6.35 %) were to be main components in the twig oil. The leaf oil indicated cytotoxic activity against three cancer cell lines HepG2, MCF7 and A549 with the IC50 values of 60.96–69.93 μg/mL, while the twig oil inhibited MCF7 with the IC50 value of 66.70 μg/mL. Additionally, the twig oil successfully suppressed the growth of the negative Gram bacterium Pseudomonas aeruginosa, fungus Aspergillus niger, and yeast Candida albicans with the same MIC value of 50 μg/mL, whereas the leaf oil had the same result on the negative Gram bacterium Escherichia coli.

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An Unusual Bisnor-clerodane Diterpenoid from Polyalthia Simiarum

Cited by 8 publications

References 16 publications

Phytochemicals from Polyalthia Species: Potential and Implication on Anti-Oxidant, Anti-Inflammatory, Anti-Cancer, and Chemoprevention Activities

Phytochemicals from Polyalthia Species: Potential and Implication on Anti-Oxidant, Anti-Inflammatory, Anti-Cancer, and Chemoprevention Activities

Clerodane diterpenes: sources, structures, and biological activities

Essential Oils of Polyalthia suberosa Leaf and Twig and Their Cytotoxic and Antimicrobial Activities

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