Antimicrobial, Cytotoxicity and Photocatalytic Degradation of Norfloxacin Using Kleinia grandiflora Mediated Silver Nanoparticles

Kanagamani, Krishnaswamy; Muthukrishnan, Pitchaipillai; Shankar, K. Ravi; Kathiresan, Ayyasami; Barabadi, Hamed; Saravanan, Muthupandian

doi:10.1007/s10876-019-01583-y

Cited by 63 publications

(22 citation statements)

References 54 publications

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“…Furthermore, these biomolecules also act as capping and stabilizing agents for the biosynthesized nanoparticles [28][29][30]. In the literature, several plant extracts have been employed for the synthesis of silver nanoparticles and these examples include; Chrysanthemum indicum L. [31], Ceropegia thwaitesii [32], Datura stramonium [33], Cleome viscosa L. [34], Nepeta deflersiana [35] Berberis vulgaris [28], Myrtus communis [36] Kleinia grandiflora [37], Phyllanthus pinnatus [4].…”

Section: Introductionmentioning

confidence: 99%

Plant-Based Synthesis of Silver Nanoparticles Using Aqueous Leaf Extract of Salvia officinalis: Characterization and its Antiplasmodial Activity

2020

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In the present study, an aqueous leaf extract of Salvia officinalis was used to synthesize silver nanoparticles (AgNPs) and characterized with different techniques such as UV-vis spectroscopy, Fourier transform infrared (FTIR), X-ray diffraction (XRD), Scanning electron microscope (SEM), Energy dispersive X-ray spectroscopy (EDX), Transmission electron microscope (TEM) and thermogravimetric analysis (TGA). Subsequently, its cytotoxic effect against human cervix adenocarcinoma (HeLa) cells and antiplasmodial activity against Plasmodium falciparum were investigated. UV-vis spectrum of AgNPs displayed an absorption peak at 323 nm and TEM result revealed it to be spherical in shape with average size of 41 nm. FTIR results highlighted the key bioactive compounds that could be responsible for the reduction and capping of AgNPs and XRD analysis showed its crystalline nature with a face-centered cubic (fcc) structure. The synthesized AgNPs was found to be less cytotoxic against HeLa cells line and demonstrated good antiplasmodial potential (IC 50 = 3.6 lg/mL). Findings from this study indicated that the AgNPs could serve as a template in the development of new drugs for the control of malaria and hence, further study is needed to identify and characterize the potent molecules that suppress the malaria parasite.

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Section: Introductionmentioning

confidence: 99%

Plant-Based Synthesis of Silver Nanoparticles Using Aqueous Leaf Extract of Salvia officinalis: Characterization and its Antiplasmodial Activity

2020

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“…Earlier reports have suggested that plant formulated syntheses of AgNPs are responsible for the generation of oxidative stress, caspase dependent apoptosis, and mitochondrial dysfunction [59]. The cytotoxic effect of AgNPs formulated from the extracts of Kleinia grandiflora [60] or Punica granatum on DNA damage in cancer cells also provides evidence that such NPs might have anticancer activities [61].…”

Section: Apoptosis Studymentioning

confidence: 96%

Facile Synthesis of Silver Nanoparticles Using Asian Spider Flower and Its In Vitro Cytotoxic Activity Against Human Breast Carcinoma Cells

Balashanmugam

Prabhu²,

Thiyagarajan

et al. 2020

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Cancer is one of the most dangerous threats to human health and possibly the utmost task for current medicine. Currently, bio-based synthesis of nanoparticles from plants has gained much interest due to its potential medicinal applications. In the present study, a biological approach was employed for biogenic (green) synthesis of silver nanoparticles (AgNPs) using dried leaf extract of Asian spider flower (Asf). The biogenic synthesis of Asf-AgNPs (Asian spider flower-Silver nanoparticles) was established using ultra violet-visible (UV-vis) spectra which exhibited a wide superficial plasmon resonance of AgNPs at 445 nm. These nanoparticles clearly showed the formation of poly-disperse crystalline solids (spherical shape) with particle size range of <50 nm based on observation under a transmission electron microscope (TEM). Infrared spectroscopy (FTIR) revealed carboxylic acids (C = O stretch) known to act as a capping agent and a reductant in plant extracts. Elemental silver signal peak was observed in the graph obtained from energy-dispersive X-ray (EDX) analysis. Biocompatibility tests for Asf-AgNPs at different doses were evaluated against human breast cancer cells (MCF7) for cell viability and apoptotic analysis. According to the evaluation, biosynthesized Asf-AgNPs could prevent the explosion of human breast tumor cells (MCF7) in IC50 at a dose of 40 μg/mL after 48 h of treatment. The results obtained in the IC50 dosage treatments were statistically significant (p < 0.05) when compared with control. Nuclear damage of cells was further investigated using annexin V-FITC/PI dual staining and DAPI (4′,6-diamidino-2-phenylindole) staining method. Bright blue fluorescence with condensed and fragmented chromatin was observed. Western blot analysis showed increased expression levels of caspases-3 and 9 (apoptotic proteins). These results indicate that bio-approached AgNPs synthesized through Asf plant extract could be used as potential therapeutic medications for human cancer cells.

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“…The available radicals (OHc and Hc) are adequate to separate hydrogen atoms from nystatin to create nystatin free radicals (secondary radicals ¼ C 47 H 74 NO 17 ; eqn (5)) then, the nystatin radicals react with Bi 3+ to create Bi 2 O 3 NPs and constant nystatin molecules (eqn (6)).…”

Section: Proposal Reaction Mechanism For Bi 2 O 3 Nps Synthesismentioning

confidence: 99%

“…Due to the encouraging characteristics of the prepared metal oxide NPs, they have found possible applications in biomedicine as anticancer and antimicrobial agents. 17 However, the interactions between metal oxide NPs and biological systems depend on the cell type and uptake routes or the direction of different organelles. Despite the evolution of research in nanotechnology, there remain considerable challenges to overcome, including safety, scale-up production, decreasing costs, and understanding the biological activity.…”

Section: Introductionmentioning

confidence: 99%

Nystatin-mediated bismuth oxide nano-drug synthesis using gamma rays for increasing the antimicrobial and antibiofilm activities against some pathogenic bacteria andCandidaspecies

et al. 2020

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Antimicrobial, Cytotoxicity and Photocatalytic Degradation of Norfloxacin Using Kleinia grandiflora Mediated Silver Nanoparticles

Cited by 63 publications

References 54 publications

Plant-Based Synthesis of Silver Nanoparticles Using Aqueous Leaf Extract of Salvia officinalis: Characterization and its Antiplasmodial Activity

Plant-Based Synthesis of Silver Nanoparticles Using Aqueous Leaf Extract of Salvia officinalis: Characterization and its Antiplasmodial Activity

Facile Synthesis of Silver Nanoparticles Using Asian Spider Flower and Its In Vitro Cytotoxic Activity Against Human Breast Carcinoma Cells

Nystatin-mediated bismuth oxide nano-drug synthesis using gamma rays for increasing the antimicrobial and antibiofilm activities against some pathogenic bacteria andCandidaspecies

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