Antimicrobial culture sensitivity pattern in neonatal sepsis in a tertiary-care hospital

Abstract

Background: Bacterial sepsis is one of the most common causes of mortality and morbidity in neonates. The spectrum of bacteria that cause neonatal sepsis varies, and antibiotic resistance is an increasing problem of these bacteria. Objective: To determine the bacteriological profile and antibiotic sensitivity pattern of neonatal sepsis in the neonatal intensive-care unit (NICU), so that the empirical antibiotics can be decided to tackle the organisms in the NICU.

Profile of Bacterial Isolates in Neonatal Blood Culture and Their Antibiotic Susceptibility Patterns (Antibiogram) in Neonatal Sepsis at a Tertiary Care Hospital Nicu in South India

“…This is comparable with studies reported by Vaniya HV et al, 6 Shrestha et al, 7 Lamba M et al, 13 Meher et al 11 and Kayange et al 14 Predominance of Gram-negative organisms as high as 70% was found in Rehaman et al 15 study.…”

“…aureus (20.25%), E. coli (13.29%), Pseudomonas (12.66%) and CONS (10.76%). Klebsiella was the predominant organism isolated in Neonatal sepsis in previous studies reported by Vaniya HV et al, 6 Shrestha et al, 7 Jyothi et al 11 and Aletayeb et al 16 Whereas Pseudomonas and Staph. aureus were the predominant isolates in Neonatal sepsis in the studies done by Bhat et al 17 The analysis of Antibiogram of our study revealed decreased sensitivity among Gram-negative isolates against commonly used antibiotics such as Ampicillin, Amoxicillin, Amoxiclav and Cefotaxime and Ceftriaxone.…”

“…Only few Gram-negative isolates in our study were found sensitive to Ciprofloxacin and Ofloxacin. But in Vaniya et al 6 study, their Gram-negative isolates were most sensitive to Ciprofloxacin (56.05%) and Ofloxacin (60.09%).…”

Incidence of Late Onset Culture Positive Neonatal Sepsis and Its Antibiotic Sensitivity Pattern.

“…Similar results were reported by Roy et al and Jain A et al [37,38]. Similar preponderance of the gram-negative rods has been reported in other studies conducted in India [25,[27][28][29][30]. In a study by Gupta et al Klebsiella pneumonia and Escherichia coli were the commonest isolates in 42.30% and 38.46% of cases, respectively [26].…”

“…Male to female ratio was noted as 2.5:1 by Shah et al [30]. In a similar study by Vaniya et al, out of the 713 patients with neonatal sepsis, 449 (62.97%) were male and 264 (37.03%) were female subjects [27]. Sawhney et al observed the prevalence of Male to female prevalence as 59.5% and 40.5% [25].…”