Antimicrobial constituents from the flowers of <i>Trollius chinensis</i>

Li, Dan-Yi; Wei, Jinxia; Hua, Hui‐Ming; Li, Zhan‐Lin

doi:10.1080/10286020.2014.927868

Cited by 16 publications

(10 citation statements)

References 9 publications

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“…Their anti-bacterial activities have been reported by cumulative evidence. For example, flavonoids are against both Gram-positive and Gram-negative bacteria in the ethanolic extracts from the leaves of Combretum album (Sunanda et al 2018), a phenolic acid isolated from the flowers of Trollius chinensis has anti-inflammatory and antibacterial effects (Li et al 2014). Moreover, the monomer composition of flavonoids and phenolic acid still have antibacterial activity.…”

Section: Discussionmentioning

confidence: 99%

Antibacterial evaluation of plants extracts against ampicillin-resistant Escherichia coli (E. coli) by microcalorimetry and principal component analysis

Qin

et al. 2019

AMB Expr

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Antibiotics abuse has caused increased bacterial resistance, which severely limits the application of antibiotics to the treatment of bacterial infections. Therefore, it is urgent to develop new antibacterial drugs through other sources. Dracontomelon dao (Blanco) Merr. & Rolfe (Ren Mianzi in Chinese) is a traditional medicinal material derived from Anacardiaceae with a long history of treating various infectious diseases, such as decubitus and skin ulcers. Recent research has indicated that different extracts from the leaves of D. dao , especially the ethyl acetate (EtOAc) fraction containing flavonoids and phenolic acids, exhibit potent antibacterial activities. In this research, the combined anti-drug-resistant bacterial activities of these active ingredients were investigated. Six samples (S1–S6) were obtained from the EtOAc fraction of D. dao leaves. Microcalorimetric measurements and principal component analysis were performed on the in vitro samples. The results showed that all six samples had notable antibacterial activities. Specifically, sample S6 exhibited a prominent antibacterial effect, with an IC 50 value of 84.3 μg mL −1 , which was significantly lower than that of other samples. The relative contents of main flavonoids and phenolic acids in S6 sample were confirmed by UPLC/Q-TOF-MS. In conclusion, sample S6 from the EtOAc fraction of D. dao leaves could be used as a potential antimicrobial resource in the treatment of infectious diseases. This work provides an insight into the effect of traditional Chinese medicine on drug-resistant bacteria. Moreover, the purification and characterization of the chemical compounds from the sample S6 deserve further analysis.

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Section: Discussionmentioning

confidence: 99%

Antibacterial evaluation of plants extracts against ampicillin-resistant Escherichia coli (E. coli) by microcalorimetry and principal component analysis

Qin

et al. 2019

AMB Expr

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“…In order to study the bioactive constituents of A. amoiensis, a chemical investigation was carried out and led to the isolation of one new compound, named amauroamoienin (1), along with thirteen known compounds (2-14) (l " Fig. 1), 4-hydroxy-17methylincisterol (2) [11], (l7R)-17-methylincisterol (3) [12], 1,5dihydroxy-6′,6′-dimethylpyrano[2′,3′: 3,2] xanthone (4) [13], jacareubin (5) [13], ergosterol peroxide (6) [14], ergosta-7,22-dien-3β-ol (7) [15,16], (22E,24R)-ergosta-8,22E-diene-3β,5α,6β,7αtetraol (8) [17,18], 22E-7α-methoxy-5α,6α-epoxyergosta-8 (14),22-dien-3β-ol (9) [19], 3β,5α,9α-trihydroxyergosta-7,22-dien-6-one (10) [20,21], 1H-indole-3-carboxylic acid (11) [22], phydroxybenzoic acid (12) [23], methyl 3,4-dihydroxybenzoate (13) [24], and 7,8-dimethylalloxazine (14) [25]. Herein, we describe the isolation and structural elucidation of the new compound (1) [14] hinted that 1 had a xanthone moiety with the same structure of that of 5, which was also confirmed by olefinic and aromatic pro- , among which an epoxy group was formed based on analysis of its molecular formula.…”

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confidence: 99%

Chemical Constituents from the Fungus Amauroderma amoiensis and Their In Vitro Acetylcholinesterase Inhibitory Activities

et al. 2012

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!One new compound named amauroamoienin (1), together with thirteen known compounds (2-14), was isolated from the EtOAc extract of Amauroderma amoiensis. The structures of these compounds were elucidated by the analysis of 1D and 2D spectroscopic data and the MS technique. The bioassays of inhibitory activities of these isolates against acetylcholinesterase were evaluated, and compounds 1, 3, and 5 exhibited acetylcholinesterase inhibitory activities.

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“…Preceding studies on the pharmacological activity globeflowers, however, were mostly confined to only one species of Trollius, without comparing the differences among frequently used globeflowers, such as T. chinensis and T. ledebouri [10][11][12]. In most cases, Chinese medicine practitioners do not differentiate between T. chinensis and T. ledebouri and consider them as one [2].…”

Section: Introductionmentioning

confidence: 99%

Extensive Profiling of Polyphenols from Two Trollius Species Using a Combination of Untargeted and Targeted Approaches

et al. 2020

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Various species of globeflowers, belonging to the genus Trollius, have been extensively used in traditional Chinese medicine due to their anti-inflammatory, antimicrobial, and antiviral properties, which are mainly attributed to their high polyphenol content. Differences in polyphenol composition, and abundances, will lead to varying treatment efficacies of globeflowers. Herein, we employ a combination of targeted and untargeted mass spectrometry (MS) approaches to characterize and quantify a comprehensive array of polyphenols, mainly including flavonoids and phenolic acids in two globeflower species commonly used in Chinese medicine, Trollius chinensis Bunge and Trollius ledebouri Reichb. In addition, free radical scavenging activity was investigated to evaluate the association between polyphenol composition and antioxidation capacity. Liquid chromatography (LC)-based separation and multiple-reaction-monitoring (MRM) transitions were optimized using a library of 78 polyphenol reference compounds to achieve absolute quantification on triple quadrupoles MS (QqQ). The analytical method was further expanded via high-resolution MS to provide relative quantitation of an additional 104 endogenous polyphenols in globeflowers not included in our reference library. Our results revealed stark differences in polyphenol content between T. chinensis and T. ledebouri, emphasizing the need for systematic characterization of polyphenol composition to ensure treatment efficacy and consistency in standardizing the use of globeflowers in Chinese medicine.

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Antimicrobial constituents from the flowers of Trollius chinensis

Cited by 16 publications

References 9 publications

Antibacterial evaluation of plants extracts against ampicillin-resistant Escherichia coli (E. coli) by microcalorimetry and principal component analysis

Antibacterial evaluation of plants extracts against ampicillin-resistant Escherichia coli (E. coli) by microcalorimetry and principal component analysis

Chemical Constituents from the Fungus Amauroderma amoiensis and Their In Vitro Acetylcholinesterase Inhibitory Activities

Extensive Profiling of Polyphenols from Two Trollius Species Using a Combination of Untargeted and Targeted Approaches

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