Antimicrobial cationic acrylate-based hybrid coatings against microorganism contamination

Wang, Fawei; Wang, Bin; Li, Xuemei; Wu, Zhan-Min; He, Yufeng; Song, Pengfei

doi:10.1016/j.porgcoat.2020.105576

Cited by 17 publications

(8 citation statements)

References 29 publications

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“…For nonleachable antimicrobial coatings, as shown in Figure 7, Wang et al synthesized cationic acrylate copolymers (PAMs) using 3-(methacryloylamino)propyltrimonium chloride (MPAC) with three acrylates, which used the electrostatic action of MPAC and the ROS produced by TiO 2 to jointly resist microbial contamination. 116 Similarly, Daniels et al prepared sol−gel coatings containing fluorosilanes and QAS (FQSGC), and the synergistic effect of the fluorosilanes and QAS reduced the surface free energy and preserved antimicrobial properties. 117 Li et al also prepared quaternized poly(N,N-dimethylaminoethyl methacrylate)-b-poly(1H,1H,2H,2H-heptadecafluorodecyl acrylate) block copolymers (PDMA-b-PFOEMA), and the migration of fluorinecontaining blocks in the copolymers improved the biocompatibility.…”

Section: Qass Antibacterialmentioning

confidence: 99%

“…Antimicrobial coatings can also be subdivided into nonleachable and water-soluble types. For nonleachable antimicrobial coatings, as shown in Figure , Wang et al synthesized cationic acrylate copolymers (PAMs) using 3-(methacryloylamino)propyltrimonium chloride (MPAC) with three acrylates, which used the electrostatic action of MPAC and the ROS produced by TiO 2 to jointly resist microbial contamination . Similarly, Daniels et al.…”

Section: Application Of Qassmentioning

confidence: 99%

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Quaternary Ammonium Salts: Insights into Synthesis and New Directions in Antibacterial Applications

Zhou

Zhou²,

Zhang

et al. 2023

Bioconjugate Chem.

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The overuse of antibiotics has led to the emergence of a large number of antibiotic-resistant genes in bacteria, and increasing evidence indicates that a fungicide with an antibacterial mechanism different from that of antibiotics is needed. Quaternary ammonium salts (QASs) are a biparental substance with good antibacterial properties that kills bacteria through simple electrostatic adsorption and insertion into cell membranes/altering of cell membrane permeability. Therefore, the probability of bacteria developing drug resistance is greatly reduced. In this review, we focus on the synthesis and application of single-chain QASs, double-chain QASs, heterocyclic QASs, and gemini QASs (GQASs). Some possible structure–function relationships of QASs are also summarized. As such, we hope this review will provide insight for researchers to explore more applications of QASs in the field of antimicrobials with the aim of developing systems for clinical applications.

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Section: Qass Antibacterialmentioning

confidence: 99%

Section: Application Of Qassmentioning

confidence: 99%

Quaternary Ammonium Salts: Insights into Synthesis and New Directions in Antibacterial Applications

Zhou

Zhou²,

Zhang

et al. 2023

Bioconjugate Chem.

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“…As mentioned in Section 3.3, MEQABr‐ x ( x = 12, 14, 16) could form micelles, that play a role in emulsifier. With the increase of MEQABr‐14 content or alkyl chain length of MEQABr‐ x ( x = 12, 14, 16), there were more micelles in SAQ x ‐ n emulsion compared with SA emulsion that facilitating the reaction and stabilizing the particles, 33 therefore, compared with SA emulsion, the gel content and particle sizes decreased, the solid content, and conversation rate increased (Figure 4A–F). However, the solid content, the conversation rate and the particle sizes showed an opposite trend when the content of MEQABr‐14 further increased to 9 wt% (based on films) (Figure 4B,C), that was the increasing number of alkyl chain of MEQABr‐14 aggregated in micelles, as well as the formation of hydrogen bonds of the carbamate in MEQABr‐14 and COOH in AA, would result in the trap of monomers in copolymers chains, making it difficult to diffuse and react with free radicals, therefore the solid content and conversation rate decreased (Figure 4B,C), the particle sizes increased (Figure 4I–L).…”

Section: Resultsmentioning

confidence: 99%

Preparation and properties of antibacterial styrene‐acrylic emulsion based on bis‐quaternary ammonium salt‐containing mono‐methacrylates as polymerizable antibacterial agents

Zhou

Xiong³

et al. 2021

Polymers for Advanced Techs

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With the aim to prepare antibacterial styrene‐acrylic emulsion, a series of bis‐quaternary ammonium salt‐containing mono‐methacrylates MEQABr‐x(x = 12, 14, 16) were synthesized as polymerizable antibacterial agents via two steps. The chemical structures of MEQABr‐x(x = 12, 14, 16) were confirmed by proton nuclear magnetic resonance (1H‐NMR) and Fourier transform infrared (FTIR). The Minimum inhibitory concentration (MIC), Minimum bactericidal concentration (MBC), and Critical micelle moncentration (CMC) results showed that MEQABr‐x(x = 12, 14, 16) had antibacterial properties and surface properties which was influenced by its alkyl chain length. The antibacterial emulsion (SAQx‐n) was synthesized by emulsion polymerization of styrene (St), butyl acrylate (BA), acrylic acid (AA) and MEQABr‐x(x = 12, 14, 16). The structures of its films (SAQx‐n‐F) were characterized by attenuated total reflectance‐FTIR. The effects of MEQABr‐14 content or alkyl chain length of MEQABr‐x(x = 12, 14, 16) on emulsion and its films were investigated in the aspect of particle sizes, pencil hardness, adhesive force grade, thermal stabilities, surface morphology, particle morphology, and so forth. The films (SAQx‐9‐F) with 9 wt% content of MEQABr‐x(x = 12, 14, 16) showed the nearly 100% antibacterial rate against Escherichia coli and Staphylococcus aureus, indicating its potential to be used as antibacterial coating.

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“…Hitherto, one of very important research field was exploiting antibacterial agents, 6,7 such as antibacterial agents based on metals (e.g., silver, copper, and zinc) and its compounds, quaternary ammonium salts (QASs), and its derivatives, and others 8 . Among them, some different QASs were explored their low hypotoxicity, excellent antibacterial ability, 9,10 and good stability 11 . However, QASs is small molecule compounds that easy to migrate and cause environmental pollution.…”

Section: Introductionmentioning

confidence: 99%

Reversible addition‐fragmentation chain transfer polymerization for fabrication of polymer cations‐adjustable porous materials with excellent antibacterial activity

Guo

Cao

Dai

et al. 2022

Polymers for Advanced Techs

Self Cite

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The reversible addition-fragmentation chain transfer polymerization (RAFT) is an effective method to control chain growth and regulate active centers in functional materials.Herein, a novel antibacterial material, polymer cations-adjustable porous materials (PCaPM), was successfully synthesized by RAFT and quaternization. First, using 2-(dodecylsulfanylthiocarbonylsulfanyl)-2-methylpropionic acid as the chain transfer agent of RAFT, methyl methacrylate and 2-(dimethylamino)ethyl methacrylate as comonomers, and ethylene dimethacrylate as crosslinking agent, the light-yellow crosslinked block copolymer (PM-PDE), was synthesized by RAFT polymerization. Second, a series of porous materials (PCaPM) were obtained by quaternization of PM-PDE with alternative alkyl halide and swelling effects in water. The composition and structure of PM-PDE and PCaPM were characterized by scanning electron microscope, energy dispersive spectrometer, Fourier transform infrared spectra, 1 H-NMR, Brunauer-Emmett-Teller, and X-ray photoelectron spectroscopy. Their antibacterial properties were also evaluated against Staphylococcus aureus, Escherichia coli, and Valsa mali. Remarkably, PCaPM, containing tertiary amine and possessing high porosity and large specific surface area, presented excellent antibacterial activity. Hence, the resultant PCaPM exhibited excellent antibacterial activity due to the quaternary ammonium salts groups, which has great prospects in application in medical treatment, agricultural antibiotic, emulator, and sewage treatment.

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Antimicrobial cationic acrylate-based hybrid coatings against microorganism contamination

Cited by 17 publications

References 29 publications

Quaternary Ammonium Salts: Insights into Synthesis and New Directions in Antibacterial Applications

Quaternary Ammonium Salts: Insights into Synthesis and New Directions in Antibacterial Applications

Preparation and properties of antibacterial styrene‐acrylic emulsion based on bis‐quaternary ammonium salt‐containing mono‐methacrylates as polymerizable antibacterial agents

Reversible addition‐fragmentation chain transfer polymerization for fabrication of polymer cations‐adjustable porous materials with excellent antibacterial activity

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