Antimicrobial Biomimetics

María, Ana; Barbassa, Lilian; Melo, Letcia Dias de

doi:10.5772/14400

Cited by 3 publications

(4 citation statements)

References 341 publications

(517 reference statements)

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“…Other lipid-polymer hybrid nanoparticles consist of a polymer core surrounded by a lipid shell combining properties of both polymeric nanoparticles and liposomes and often referred to as biomimetic nanoparticles [14][15][16][17][18][19][20][21][22][23][55][56][57][58]. Sometimes, when the lipid has good affinity for the polymer, it can be embedded in the polymer matrix as was the case of the cationic lipid dioctadecyl dimethyl ammonium bromide (DODAB) and poly methyl methacrylate (PMMA) polymer for producing microbicidal PMMA/DODAB coatings from spin-coating [59].…”

Section: Lipid Polymer Nanoparticles: Overview On Their Applicationsmentioning

confidence: 99%

“…Cationic lipid polymer NPs and coatings are strategic for applications in antimicrobial biomimetics and vaccine design [7,8,[38][39][40][41][42][43][44][45][55][56][57][58][59]. Due to the cationic lipid, lipid polymer cationic NPs can combine effectively with antibiotics DOI: http://dx.doi.org/10.5772/intechopen.84618 like amphotericin B or miconazole [39,[68][69][70], rifampicin [71], clarithromycin [72], anti-inflammatory hydrophobic drugs like indomethacin [32], nucleic acids [21], oligonucleotides [35,73,74], proteins in general including serum proteins, transmembrane proteins, receptors and toxins [75][76][77][78], antigens [9,20,22,[34][35][36][37], peptides [23,[43][44][45] or polymers [79,80].…”

Section: Cationic Lipid Polymer Nanoparticles Coatings and Applicatimentioning

confidence: 99%

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Biomimetic Nanomaterials from the Assembly of Polymers, Lipids, and Surfactants

Carmona-Ribeiro¹

2019

Surfactants and Detergents

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Nanostructured materials require evaluation at a molecular level to become controllable and useful in drug and vaccine delivery. Over the years self-assembled nanomaterials such as nanoparticles and thin films have been prepared, characterized and used for biomedical applications. In this review meaningful examples of biomimetic nanomaterials and their construction based on intermolecular interactions such as the electrostatic attraction or the hydrophobic effect will be discussed. Emphasis will be placed on the interactions between polymers, lipids, surfactants and surfaces leading to bioactive supramolecular assemblies such as nanoparticles and coatings. Among the important applications of the self-assembled nanostructures and films to be reviewed are their antimicrobial effect and their adjuvant activity for vaccine delivery.

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Section: Lipid Polymer Nanoparticles: Overview On Their Applicationsmentioning

confidence: 99%

Section: Cationic Lipid Polymer Nanoparticles Coatings and Applicatimentioning

confidence: 99%

Biomimetic Nanomaterials from the Assembly of Polymers, Lipids, and Surfactants

Carmona-Ribeiro¹

2019

Surfactants and Detergents

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“…Quats will be strongly cationic due to their quaternary and positively charged nitrogen able to attach to surfaces, both organic and inorganic [3]. With remarkable chemical stability, they can exhibit long-lasting biocidal effects [4]. They attract anions, for example, soaps, detergents and hard water constituents, for example, carbonate and sulfate [5].…”

Section: The Quaternary Ammonium Surfactants (Quats)mentioning

confidence: 99%

The Versatile Dioctadecyldimethylammonium Bromide

Carmona-Ribeiro¹

2017

Application and Characterization of Surfactants

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Dioctadecyldimethylammonium bromide (DODAB) is a quaternary ammonium surfactant (Quat) with interesting properties and applications. In this chapter, DODAB characteristics as compared to other Quats emphasize its self-assembly in aqueous solutions and the novel applications involving this useful cationic lipid so easily combined with biomolecules and interfaces to yield a wide range of novel uses in many fields such as delivery of drugs, vaccines and genes, design of nanoparticles, modification of interfaces, and many others yet to come.

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“…Supramolecular assemblies driven by weak, non−covalent intermolecular interactions are ubiquitous in nature and carry the potential to facilitate disassembly, a property of importance in many physiological and biological events; antimicrobial biomimetics has been providing many instances of useful assemblies fully capable of disassembling and acting in an independent but complementary manner to overcome microbial resistance to pathogens [ 25 , 30 , 35 , 39 , 40 , 41 , 42 , 43 , 44 , 45 ]. A huge variety of components is possible, imparting distinct and complementary antimicrobial activities to the whole assembly.…”

Section: Introductionmentioning

confidence: 99%

Transient Coatings from Nanoparticles Achieving Broad-Spectrum and High Antimicrobial Performance

Zaia,

Quinto,

Camargo

et al. 2023

Pharmaceuticals

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Cationic and hydrophilic coatings based on casting and drying water dispersions of two different nanoparticles (NPs) onto glass are here described and evaluated for antimicrobial activity. Discoid cationic bilayer fragments (BF) surrounded by carboxy-methylcellulose (CMC) and poly (diallyl dimethyl ammonium) chloride (PDDA) NPs and spherical gramicidin D (Gr) NPs dispersed in water solution were cast onto glass coverslips and dried, forming a coating quantitatively evaluated against Pseudomonas aeruginosa, Staphylococcus aureus and Candida albicans. From plating and colony forming units (CFU) counting, all strains interacting for 1 h with the coatings lost viability from 105 to 106, to zero CFU, at two sets of Gr and PDDA doses: 4.6 and 25 μg, respectively, or, 0.94 and 5 μg, respectively. Combinations produced broad spectrum, antimicrobial coatings; PDDA electrostatically attached to the microbes damaging cell walls, allowing Gr NPs interaction with the cell membrane. This concerted action promoted optimal activity at low Gr and PDDA doses. Further washing and drying of the deposited dried coatings showed that they were washed out so that antimicrobial activity was no longer present on the glass surface. Significant applications in biomedical materials can be foreseen for these transient coatings.

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Antimicrobial Biomimetics

Cited by 3 publications

References 341 publications

Biomimetic Nanomaterials from the Assembly of Polymers, Lipids, and Surfactants

Biomimetic Nanomaterials from the Assembly of Polymers, Lipids, and Surfactants

The Versatile Dioctadecyldimethylammonium Bromide

Transient Coatings from Nanoparticles Achieving Broad-Spectrum and High Antimicrobial Performance

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