Antimicrobial, antioxidant, antitumour-promoting and cytotoxic activities of different plant part extracts of Garcinia atroviridis Griff. ex T. Anders.

Mackeen, Muhammad Mukram Mohamed; Ali, Abdul Manaf; Lajis, Nordin Hj; Kawazu, Kazuyoshi; Hassan, Zurina; Amran, M.; Habsah, M.; Lim, Yang Mooi; Mohamed, Shar Mariam

doi:10.1016/s0378-8741(00)00245-2

Cited by 133 publications

(92 citation statements)

References 21 publications

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“…Thus, these data are important for future research because, according to some authors, the toxicity of plant extracts evaluated using A. saline shows a good correlation with antitumor activity, insecticide and anti-Trypanosoma cruzi for substances with LC50<10 3 μg/mL (Meyer et al, 1982;McLauglin et al, 1991;Mackeen et al, 2000;Parra et al, 2001;Ruiz et al, 2005).…”

Section: Resultsmentioning

confidence: 99%

Anti-ulcer activity of Synadenium grantii latex

Costa¹,

David²,

Pinto³

et al. 2012

Rev. bras. farmacogn.

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Synadenium grantii Hook f., Euphorbiaceae, is popularly known as leitosinha or janaúba. The diluted latex (18 drops/L of water) is commonly used in the south of Brazil to treat gastric disturbances. This study evaluated phytochemical screening and toxicity using Artemia salina Leach of crude bark extract and also latex. The toxicity and the anti-ulcer activity of S. grantii latex were also tested in rats. Phytochemical results showed presence of tannins, terpenes, unsaponificable substances, coumarins and anthraquinones in the crude bark extract and terpenes in the latex. Gas chromatography-mass spectrometry (GC-MS) analysis demonstrated the presence of diterpene tigliane esters in the latex, identified as 12-deoxyphorbol-13-(2-metilpropionate) and phorbol 12,13,20-triacetate. The toxicity results using A. salina presented CL50 26.58μg/mL and CL50 778.66μg/mL, for the latex and the crude bark extract respectively. The toxicological hepatic parameters of the diluted latex were not different to the control group (p<0.05). The eosinophils cells showed an increase in both the diluted and pure latex groups. The pure latex showed gastric protection of 90% (p<0.05) and the diluted latex showed 6% compared to the negative control. Therefore, our data indicate that S. grantii latex, under research conditions presented gastric protection. Pure latex showed more toxicity than the diluted latex.

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Section: Resultsmentioning

confidence: 99%

Anti-ulcer activity of Synadenium grantii latex

Costa¹,

David²,

Pinto³

et al. 2012

Rev. bras. farmacogn.

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“…From a pharmacological point, a good relationship has been found with the brine shrimp lethality test to detect antitumoral compounds in terrestrial plant extracts [5,9,10] . Then, root extract as the most toxic part of L. camara is more potential to anticancer phytochemicals.…”

Section: Discussionmentioning

confidence: 99%

In vivo toxicity study of Lantana camara

Pour

Sasidharan

2011

Asian Pacific Journal of Tropical Biomedicine

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“…Despite its wide array of traditional therapeutic uses 12 , the anticancer properties of G. cambogia were previously unreported. However, recent studies have examined the anti-proliferative properties of the taxonomically related species G. mangostana 1,42 and G. atroviridis 43 and reported similar anticancer efficacies. Whilst the antimicrobial and anticancer components of G. cambogia are yet to be identified, pure xanthones isolated from the related species G. mangostana show promising therapeutic properties.…”

Section: Discussionmentioning

confidence: 99%

An examination of the antimicrobial and anticancer properties of Garcinia cambogia fruit pericarp extracts

Hart

Cock

2016

BEMS Reports

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Background:Garcinia cambogia (synonym Garcinia gummi-gutta) is commonly known as brindleberry and Malabar tamarind. It has received considerable recent interest due to its potential in the prevention and treatment of obesity and obesity related diseases. The fruit pericarp also has traditional uses in the treatment of a wide variety of diseases and medical conditions, yet these have received relatively little investigation to date. Methods: Garcinia cambogia fruit extracts were investigated for their ability to inhibit the growth of a panel of bacteria of medicinal importance. The extracts were also tested for their ability to block the proliferation of the CaCo 2 and HeLa human carcinoma cell lines. Results: Garcinia cambogia methanolic, aqueous and ethyl acetate extracts displayed broad spectrum antimicrobial activity, inhibiting the growth of between 16 (64 %; ethyl acetate extract) and 22 (88 % aqueous extract) of the 25 bacterial species tested. Strong inhibitory activity was detected with minimum inhibitory concentration (MIC) values <1000 µg/ml against many bacteria. All extracts were effective against both Gram negative and Gram positive bacteria, although Gram negative bacteria were more sensitive. All extracts displayed anti-proliferative activity against CaCo 2 and HeLa carcinoma cells, yet were non-toxic in the Artemia franciscana bioassay, with LC50 values greatly in excess of 1000 µg/ml. Conclusion: The inhibitory bioactivity against a range of microbes, the anti-proliferative activity against CaCo 2 and HeLa cells, as well as the lack of toxicity, indicate the potential for G. cambogia in the discovery and development of new natural pharmaceuticals.

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Antimicrobial, antioxidant, antitumour-promoting and cytotoxic activities of different plant part extracts of Garcinia atroviridis Griff. ex T. Anders.

Cited by 133 publications

References 21 publications

Anti-ulcer activity of Synadenium grantii latex

Anti-ulcer activity of Synadenium grantii latex

In vivo toxicity study of Lantana camara

An examination of the antimicrobial and anticancer properties of Garcinia cambogia fruit pericarp extracts

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