Antimicrobial, antioxidant and anticancer properties of globe artichoke and grape by-products as a source of the bio-active phenolic compounds

Globe Artichoke (Cynara scolymus L.) By-Products in Food Applications: Functional and Biological Properties

“…These results confirm the previous ones obtained by Salama et al (2013), who evaluated the cytotoxic properties of bract methanolic extract on the HepG2 cell line, obtaining a strong effect (IC50 69 µg/mL) [84]. The action mechanism is probably the regulation of apoptosis-related proteins, or the deregulation of the cell cycle, operated by the phenolic compounds present in the extract, as also reported by Mosehly et al (2023) [83].…”

“…Conversely, MCF-7 and Caco-2 cells' exposure to higher concentrations (750 mg/mL and 1500 mg/mL) results in a reduced cell viability (26.2% and 47%, and 19.3% and 30.4% for MCF-7 and Caco-2, respectively) [82]. Caco-2 cells were also used as a model to test a bract ethanolic extract, obtaining a higher effect (IC50 143 µg/mL) than that registered for human colon carcinoma (HCT116) (IC50 234 µg/mL) and mammalian cells (Vero) from African green monkey kidney cell lines (IC50 329 µg/mL) [83]. These results confirm the previous ones obtained by Salama et al (2013), who evaluated the cytotoxic properties of bract methanolic extract on the HepG2 cell line, obtaining a strong effect (IC50 69 µg/mL) [84].…”