Antimicrobial, Antibiofilm, and Antioxidant Activity of Functional Poly(Butylene Succinate) Films Modified with Curcumin and Carvacrol

Abstract

The use of food industry waste as bioactive compounds in the modification of biodegradable films as food packaging remains a major challenge. This study describes the preparation and bioactivity characterization of poly(butylene succinate) (PBS)-based films with the addition of the bioactive compounds curcumin (CUR) and carvacrol (CAR). Films based on PBS modified with curcumin and carvacrol at different concentration variations (0%/0.1%/1%) were prepared by solvent casting method. The antioxidant, antimicrobial, and antibiofilm properties were investigated against bacteria (Escherichia coli, Staphylococcus aureus) and fungi (Candida albicans). As a result of the modification, the films exhibited free radicals scavenging (DPPH up to 91.47% and ABTS up to 99.21%), as well as antimicrobial (6 log, 4 log, and 2 log reductions for E. coli, S. aureus, and C. albicans, respectively, for samples modified with 1% CUR and 1% CAR) activity. Moreover, antibiofilm activity of modified materials was observed (8.22–87.91% reduction of biofilm, depending on bioactive compounds concentration). PBS films modified with curcumin and carvacrol with observed bifunctional properties have many potential applications as active packaging.

Recent insight into the biomedical applications of polybutylene succinate and polybutylene succinate-based materials

“…Wastewater treatment - Blending 30 wt% PBS and 70 wt%PCL improved water uptake due to increased porosity - The blend had high water flux, flux recovery, and permeate flux of 106, 26, and 37%, respectively - In addition, the blend demonstrated higher rejection of pollution indices when compared to neat PCL [84] Poly(butylene succinateco-terephthalate) (PBST) (Figure 12c) Electrospinning Wastewater treatment - Functionalized PBST with cyclodextrin demonstrated higher efficiency in removing methylene blue (MB) dye - Also, functionalized PBST membrane exhibited a maximum adsorption capacity of 90.9 mg/g [85] Table 2 In addition, the increase in nanocrystals loading to 3 wt% results in to increase in both mechanical and barrier properties - The composites were biodegraded in approximately 3 months using wastewater treatment sludge [88,89] PBS/geraniol Twin screw extruder Bread shelf-life extension - PBS-based material containing 10 wt% geraniol showed good antimicrobial properties - Release test revealed that the migration concentration of geraniol increased with increasing humidity - Shelf-life extension results indicated that the spoilage of bread stored using the resultant material was delayed by three weeks 0 [90] PBS/Curcumin and Carvacrol Solvent casting Active packaging - The PBS films containing 1 wt% of curcumin and carvacrol demonstrated antimicrobial properties and improved antioxidant activities 0 [91] Poly(butylene-succinateco-adipate) (PBSA) based materials (Figure 12d)…”