Antimicrobial, anti-inflammatory and wound healing activity of polyherbal formulation

Dev, Suresh Kumar; Choudhury, P. K.; Srivastava, Rajnish; Sharma, Meena

doi:10.1016/j.biopha.2018.12.075

Cited by 93 publications

(56 citation statements)

References 38 publications

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“…Several investigational studies have been done on animal models using chitosan in wound healing but the majority of the results were considered unconvincing. 32 In other reported studies healing effects were observed, and in many cases the outcome was due to the synergistic upshot of the various germicidal agents and wound dressing materials, that is, heparin, 15,12 alginate, 31 and so on. The scope of the present study, however, was to develop a chitosan gel formulation and to determine the efficacy of chitosan formulation against the marketed product currently in use.…”

Section: Discussionmentioning

confidence: 97%

A Comparative Study of Chitosan Gel and Soframycin in the Management of Wounds

Khanna

Sharma

Khar³

et al. 2019

The International Journal of Lower Extremity Wounds

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Wounds and related injuries remain a major cause of death and disability. Healing of wound is a complex, highly regulated process that includes cellular, molecular, biochemical, and physiological events that permit living organisms to repair accidental lesions. Therefore, dealing with wounds has always been a subject of concern to the world, and demand for products in wound management had increased to $9.3 trillion worldwide in the health care industry, affecting economic growth. The present work aimed to assess the wound healing effect of chitosan, and a comparative profile with soframycin is established in experimental animals. Enormous research reports, the wound healing properties of chitosan, but the protective mechanism implicated in wound healing activity of chitosan is unknown. In addition to this, we evaluated the anatomical, macroscopical, and histopathological alterations in wounds of experimental rats. Collagenase activity was performed to determine the granulation tissue formation and epithelialization of wounds treated with untainted chitosan. Wounds treated with glycerated chitosan gel, that is, GCG-3 (high degree of deacetylation), showed faster healing with highest percentage of contraction as compared with the soframycin-treated group. The healing of wounds was found to be 85% in GCG-3 on the sixth day of treatment, showing significant ( P < .001) improvement in epithelial tissue. The collagenase activity in GCG-3 was 192 unit/mg of protein. Wound reepithelialization was found to be to 94 ± 4% in case of the GCG-3-treated group and 87 ± 5% in the soframycin-treated group. Higher degree of deacetylation in the chitosan, GCG-3, warrants its use in the treatment and management of dermal wounds.

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Section: Discussionmentioning

confidence: 97%

A Comparative Study of Chitosan Gel and Soframycin in the Management of Wounds

Khanna

Sharma

Khar³

et al. 2019

The International Journal of Lower Extremity Wounds

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show abstract

“…Previous studies reported that plant extracts rich in tannins, flavonoids can lead to the relaxation of the smooth muscle of the urinary tract, which could facilitate the expulsion of stones from the kidney and diminished the size of calculi in rats 36 . Flavonoids and phenolic compounds exhibit inhibitory effects against multiple microorganisms and are the natural antioxidants with antimutagenic and antiinflammatory properties 37,38 .…”

Section: Discussionmentioning

confidence: 99%

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2020

IJPSR

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“…Feruloyl-caffeoyl-glycerol shows powerful cancer prevention agent movement 7 and has a sub-atomic This concentrate can be utilized as a cost effective material for twisted mending later on because of the presence of compounds showing antimicrobial, anti-provocative, anti-oxidant, antieczemic, emollient, antiseptic action. Past examinations revealed that medications containing antimicrobial, anti-fiery movement advanced the injury recuperating process through the quickened rebuilding of harmed tissue 19 , antioxidant action improves the mending of contaminated and non-tainted injuries by decreasing the harm brought about by free radicals 20 . Emollients are re-lubing the skin while purifying, as opposed to de-lubing it; they are additionally cradled so they maintain the ordinary surface pH 21 .…”

Section: Discussionmentioning

confidence: 99%