A Comparative Study of Chitosan Gel and Soframycin in the Management of Wounds

Abstract

Wounds and related injuries remain a major cause of death and disability. Healing of wound is a complex, highly regulated process that includes cellular, molecular, biochemical, and physiological events that permit living organisms to repair accidental lesions. Therefore, dealing with wounds has always been a subject of concern to the world, and demand for products in wound management had increased to $9.3 trillion worldwide in the health care industry, affecting economic growth. The present work aimed to assess the wound healing effect of chitosan, and a comparative profile with soframycin is established in experimental animals. Enormous research reports, the wound healing properties of chitosan, but the protective mechanism implicated in wound healing activity of chitosan is unknown. In addition to this, we evaluated the anatomical, macroscopical, and histopathological alterations in wounds of experimental rats. Collagenase activity was performed to determine the granulation tissue formation and epithelialization of wounds treated with untainted chitosan. Wounds treated with glycerated chitosan gel, that is, GCG-3 (high degree of deacetylation), showed faster healing with highest percentage of contraction as compared with the soframycin-treated group. The healing of wounds was found to be 85% in GCG-3 on the sixth day of treatment, showing significant ( P < .001) improvement in epithelial tissue. The collagenase activity in GCG-3 was 192 unit/mg of protein. Wound reepithelialization was found to be to 94 ± 4% in case of the GCG-3-treated group and 87 ± 5% in the soframycin-treated group. Higher degree of deacetylation in the chitosan, GCG-3, warrants its use in the treatment and management of dermal wounds.

In vitro and in vivo wound healing activities of Globularia arabica leaf methanolic extract in diabetic rats

“…The dorsal region was shaved and one fragment was gently removed from the skin using a 10‐mm diameter circular biopsy (Figure 1). 24 The wound was cleaned with a cotton swab soaked in alcohol followed by the application of the plant extract and 1% Soframycin ointment as positive control 25 on the wound once daily for 15 days starting from the first day of wounding. The control group received all the consistents of ointment except plant extract.…”

Antimicrobial and wound healing potential of naphthoquinones encapsulated in nanochitosan

“…A successful hemostatic effect is completed by chitosan-induced inhibition of plasmin release that prevents clot dissolution. During the inflammation stage, chitosan can assist by avoiding or combating bacterial infection, as its positive charge allows it to bind with negatively charged carbohydrate, lipid and protein residues located on the cell surface of bacteria, consequently inhibiting their growth ( Kim, 2018 ; Khanna et al, 2020 ). Furthermore, chitosan exerts anti-inflammatory effects that reduce inflammatory cytokines, IL-10 and TNF-α, reducing oxidative damage and inflammation ( Yang et al, 2016 ; Mohyuddin et al, 2021 ).…”

Recent Advances in Chitosan‐Based Metal Nanocomposites for Wound Healing Applications

“…In addition to its inherent biocompatibility and nontoxicity, it also possesses effective antibacterial, healing, haemostatic, and analgesic effects associated with the cationic amine group [30]. Khanna et al studied the effect of deacetylation on wound healing [31], and the results of in vivo experiments showed that the higher the degree of deacetylation, the faster the rate of wound surface healing. CS can also be used to prepare different types of dressings, including hydrogels, fibres, films, membranes, scaffolds, and sponges, for various types of wounds; this is convenient for clinical applications [32][33][34].…”