Antimicrobial and healing-promoting properties of animal and plant oils for the treatment of infected wounds

Kennewell, TL; Mashtoub, Suzanne; Howarth, G. B.; Cowin, Allison J.; Kopecki, Zlatko

doi:10.33235/wpr.27.4.175-183

Cited by 7 publications

(5 citation statements)

References 38 publications

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“…Due to the critical issue of drug resistance, it is becoming increasingly difficult to select the most effective treatment for wound healing. Natural product-based treatments are becoming more and more popular [ 58 , 59 ]. In the past, they were used to treat wounds and kill bacteria that were resistant to multiple drugs [ 58 , 59 ].…”

Section: Resultsmentioning

confidence: 99%

“…Natural product-based treatments are becoming more and more popular [ 58 , 59 ]. In the past, they were used to treat wounds and kill bacteria that were resistant to multiple drugs [ 58 , 59 ]. In prior research, the combination of drug-delivery systems and effective components of herbal extract produced a synergistic antibacterial effect 60 ].…”

Section: Resultsmentioning

confidence: 99%

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Fabrication, Optimization, and Characterization of Antibacterial Electrospun Shellac Fibers Loaded with Kaempferia parviflora Extract

et al. 2022

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This study aimed to develop a Kaempferia parviflora (KP) extract based on electrospun shellac fibers capable of transporting methoxyflavones. This study used a Box–Behnken design to determine the optimal production parameters that influence the fiber diameter and bead-to-fiber ratio responses. The optimization step produced fibers with a small diameter (574 nm) and a lower bead-to-fiber ratio (0.48 beads per fiber) by combining 37.25% w/w shellac and 1.50% w/w KP extract with a solution feed rate of 0.8 mL/h and an electrical voltage of 18 kV. The KP extract was found to be dispersed throughout the electrospun shellac fibers during the characterization study. The results were highly correlated with the theoretical values, indicating that the regression models used to predict the response variables were adequate. A study of in vitro dissolution confirmed that KP extract-loaded electrospun shellac fibers could produce a sustained-release profile within 10 h. Additionally, KP-infused shellac fibers demonstrated antibacterial activity against Staphylococcus aureus. This KP loading method combined with shellac properties provided a new delivery system and could be used to explore novel biomedical materials.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Fabrication, Optimization, and Characterization of Antibacterial Electrospun Shellac Fibers Loaded with Kaempferia parviflora Extract

et al. 2022

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“…In broiler chickens and turkeys, the selection for fast growth rate inevitably led to increase abdominal fat deposition and drastic reduction in breeder fertility 82 , 83 . Additionally, one has to consider whether selection for increased fat deposition would alter the fatty acids composition and other bioactive ingredients in the adipose tissue and thus affecting the efficacy of the emu oil 5 .…”

Section: Discussionmentioning

confidence: 99%

“…In Canada, emu is primarily farmed to produce oil. Emu oil is rendered from both the subcutaneous and retroperitoneal fat tissues 1 and has anti‐inflammatory and antioxidant formulation with reparative properties 2 – 5 . Topical application of emu oil has been shown to reduce inflammation associated with reduced levels of interleukin 1-alpha (IL-1α), tumor necrosis factor-alpha (TNFα) and other proinflammatory cytokines in a croton-oil-induced inflammation mouse model 6 , 7 .…”

Section: Introductionmentioning

confidence: 99%

Seasonal and sexual variation in mRNA expression of selected adipokine genes affecting fat deposition and metabolism of the emu (Dromaius novaehollandiae)

Kim

Bennett

Wright

et al. 2022

Sci Rep

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Emus are farmed for fat production. Oil rendered from their back and abdominal fat pads has good anti-oxidant and anti-inflammatory properties and has ingredients that promote cell growth. Our objective is to examine the mRNA expression of 7 emu adipokine genes (eFABP4, eSCD1, eAdipoQ, eAdipoR1, eAdipoR2, eLEP and eLepR) to identify gene markers that may help improve emu fat production. Back and abdominal fat tissues from 11 adult emus were biopsied at four time points (April, June, August and November). Total RNA was isolated and cDNA was synthesized. Gene specific primers were designed for partial cloning fragments to amplify the open reading frame of the 7 genes. eLEP was not expressed in emu fat tissue. Nucleotides and amino acids sequences of the 6 expressed gene were compared with homologs from other species and phylogenetic relationships established. Seasonal mRNA expression of each gene was assessed by quantitative RT-PCR and differential expression analysed by the 2−ΔΔCT method. The 6 expressed genes showed seasonal variation in expression and showed association of expression level with back fat adiposity. More whole-genome scanning studies are needed to develop novel molecular markers that can be applied to improve fat production in emus.

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“…It is also used for preventing degenerative diseases because of its antioxidant effects [ 11 ]. Clove bud oil is a common healing agent for wounds and burns in traditional medicine [ 12 ]. The antibacterial and wound infection control efficacy of clove bud oil and its interaction with imipenem were determined in the present study.…”

Section: Introductionmentioning

confidence: 99%

Antibacterial Activity of Syzygium aromaticum (Clove) Bud Oil and Its Interaction with Imipenem in Controlling Wound Infections in Rats Caused by Methicillin-Resistant Staphylococcus aureus

et al. 2022

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Methicillin-resistant Staphylococcus aureus (MRSA) is one of the leading causes of infection worldwide. Clove oil’s ability to inhibit the growth of MRSA was studied through in vitro and in vivo studies. The phytochemical components of clove oil were determined through gas chromatography-mass spectrometry (GC-MS) analysis. The antibacterial effects of clove oil and its interaction with imipenem were determined by studying MIC, MBC, and FIC indices in vitro. The in vivo wound-healing effect of the clove oil and infection control were determined using excision wound model rats. The GC-MS analysis of clove oil revealed the presence of 16 volatile compounds. Clove oil showed a good antibacterial effect in vitro but no interaction was observed with imipenem. Clove bud oil alone or in combination with imipenem healed wounds faster and reduced the microbial load in wounds. The findings of this study confirmed the antibacterial activity of clove oil in vitro and in vivo and demonstrated its interaction with imipenem.

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Antimicrobial and healing-promoting properties of animal and plant oils for the treatment of infected wounds

Abstract: For referencing Kennewell TL et al. Antimicrobial and healing-promoting properties of animal and plant oils for the treatment of infected wounds.

Cited by 7 publications

References 38 publications

Fabrication, Optimization, and Characterization of Antibacterial Electrospun Shellac Fibers Loaded with Kaempferia parviflora Extract

Fabrication, Optimization, and Characterization of Antibacterial Electrospun Shellac Fibers Loaded with Kaempferia parviflora Extract

Seasonal and sexual variation in mRNA expression of selected adipokine genes affecting fat deposition and metabolism of the emu (Dromaius novaehollandiae)

Antibacterial Activity of Syzygium aromaticum (Clove) Bud Oil and Its Interaction with Imipenem in Controlling Wound Infections in Rats Caused by Methicillin-Resistant Staphylococcus aureus

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