Antibacterial Activity of Syzygium aromaticum (Clove) Bud Oil and Its Interaction with Imipenem in Controlling Wound Infections in Rats Caused by Methicillin-Resistant Staphylococcus aureus

Alanazi, Abdulaziz Khaleef; Alqasmi, Mohammed; Alrouji, Mohammed; Kuriri, Fahd A.; Almuhanna, Yasir; Joseph, Babu; Asad, Mohammed

doi:10.3390/molecules27238551

Cited by 16 publications

(4 citation statements)

References 63 publications

(49 reference statements)

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“…The addition of clove oil actually increased antimicrobial activities against all test microbes except C. krusei. Clove oil has been reported for its good antibacterial effect, ability to heal wounds faster, and its ability to diminish the microbial load in wounds [65]. Clove oil causes a considerable reduction in the quantity of ergosterol, a specific fungal cell membrane component [66].…”

Section: Antimicrobial Activitiesmentioning

confidence: 99%

Clotrimazole-Loaded Borneol-Based In Situ Forming Gel as Oral Sprays for Oropharyngeal Candidiasis Therapy

Lertsuphotvanit

Tuntarawongsa

Jitrangsri

et al. 2023

Gels

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Oral candidiasis encompasses fungal infections of the tongue and other oral mucosal sites with fungal overgrowth and its invasion of superficial oral tissues. Borneol was assessed in this research as the matrix-forming agent of clotrimazole-loaded in situ forming gel (ISG) comprising clove oil as the co-active agent and N-methyl pyrrolidone (NMP) as a solvent. Their physicochemical properties, including pH, density, viscosity, surface tension, contact angle, water tolerance, gel formation, and drug release/permeation, were determined. Their antimicrobial activities were tested using agar cup diffusion. The pH values of clotrimazole-loaded borneol-based ISGs were in the range of 5.59–6.61, which are close to the pH of 6.8 of saliva. Increasing the borneol content in the formulation slightly decreased the density, surface tension, water tolerance, and spray angle but increased the viscosity and gel formation. The borneol matrix formation from NMP removal promoted a significantly (p < 0.05) higher contact angle of the borneol-loaded ISGs on agarose gel and porcine buccal mucosa than those of all borneol-free solutions. Clotrimazole-loaded ISG containing 40% borneol demonstrated appropriate physicochemical properties and rapid gel formation at microscopic and macroscopic levels. In addition, it prolonged drug release with a maximum flux of 370 µg·cm−2 at 2 days. The borneol matrix generated from this ISG obsentively controlled the drug penetration through the porcine buccal membrane. Most clotrimazole amounts still remained in formulation at the donor part and then the buccal membrane and receiving medium, repectively. Therefore, the borneol matrix extended the drug release and penetration through the buccal membrane efficiently. Some accumulated clotrimazole in tissue should exhibit its potential antifugal activity against microbes invading the host tissue. The other predominant drug release into the saliva of the oral cavity should influence the pathogen of oropharyngeal candidiasis. Clotrimazole-loaded ISG demonstrated efficacious inhibition of growth against S. aureus, E. coli, C. albicans, C. krusei, C. Lusitaniae, and C. tropicalis. Consequently, the clotrimazole-loaded ISG exhibited great potential as a drug delivery system for oropharyngeal candidiasis treatment by localized spraying.

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Section: Antimicrobial Activitiesmentioning

confidence: 99%

Clotrimazole-Loaded Borneol-Based In Situ Forming Gel as Oral Sprays for Oropharyngeal Candidiasis Therapy

Lertsuphotvanit

Tuntarawongsa

Jitrangsri

et al. 2023

Gels

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“…Moreover, It has antioxidant action so it utilizes in preventing some degenerative diseases. Syzygium aromaticum bud oil heals wounds and burns Alanazi et al (2022).…”

Section: Introductionmentioning

confidence: 99%

Antibacterial and Antioxidant Properties of Some Plant Extracts With Propolis

Aydin,

Kadioğlu

2024

J. Ayu. Her. Integr. Med.

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For many years, plants have been utilized in food, healing materials, and curing for many illnesses. Lately, improvements in biological searches have displayed the notable potential of natural compounds.Objective: In this study, biological activities of extracts of herbal mixtures with propolis were investigated.Materials and Methodology: Ethanol and hexane extracts of propolis-Syzygium aromaticum mixture, propolis-Papaver somniferum mixture, propolis-Foeniculum sp. mixture were used in the assays.Results: Ethanol extracts exhibited higher antibacterial activity compared to hexane extracts. While ethanol extracts inhibited bacterial growth ranges from 7±1.41 mm to 19.5±2.12 mm, hexane extracts showed inhibition zones ranges from 7±0.00 mm to 14±1.41 mm. The maximum and the minimum total phenolic contents were detected in propolis-S. aromaticum ethanol extracts as 389.81±0,001 μg GAE/mL and in propolis-Foeniculum sp. as 100.57±0.012 μg GAE/mL, respectively.Conclusion: Studied plant extracts with propolis might be an option to synthetic antioxidant and antibacterial compounds.

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“…In ammatory phase, proliferation or granulation phase, and remodeling or maturation phase are the three interactive and overlapping phases of wound healing (Saporito et One of the biggest issues when treating wounds is the development of infections because they cause the patient's systemic harm by delaying the lesion's healing. Additionally, it is important to note that the immune system's response is exacerbated by the growth of the microbial load, which can result in sepsis and even critical colonization (Wang et al, 2021;Alanazi et al, 2022).…”

Section: Introductionmentioning

confidence: 99%

Development of gel containing Psidium glaziovianum essential oil has in vitro antimicrobial activity and improves healing of excisional wounds in mice

Costa

Guimarães

Silva

et al. 2023

Preprint

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Wounds are physical, chemical, biological or even medical procedure-related damage to the skin or mucous membranes. One of the major problems in the treatment of wounds is the development of infections, as they cause systemic damage to the patient, delaying recovery from the injury. In order to accelerate the healing process, there is currently an interest in finding drugs that can interact with the injured tissue and fight the associated infections. Previously P. glaziovianum essential oil (PgEO) has been shown to have antinociceptive and anti-inflammatory properties, as well as minimal oral toxicity. Therefore, our objective was to evaluate the impact of topical application of a gel formulation containing PgEO in excisional wounds in mice. Additionally, in vitro antimicrobial evaluation was also performed. The results of this research demonstrate that the gel containing essential oil of P. glaziovianum has action against gram-positive and gram-negative bacteria, as well as fungi. Furthermore, the results show that PgEO gel therapy improves skin wound healing, presumably because of its ability to stimulate antioxidant enzymes and inhibit pro-inflammatory cytokines. The gel also demonstrated minimal erythrocyte toxicity and skin irritation, which may hold promise for future preclinical and clinical studies in various types of wounds.

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Antibacterial Activity of Syzygium aromaticum (Clove) Bud Oil and Its Interaction with Imipenem in Controlling Wound Infections in Rats Caused by Methicillin-Resistant Staphylococcus aureus

Cited by 16 publications

References 63 publications

Clotrimazole-Loaded Borneol-Based In Situ Forming Gel as Oral Sprays for Oropharyngeal Candidiasis Therapy

Clotrimazole-Loaded Borneol-Based In Situ Forming Gel as Oral Sprays for Oropharyngeal Candidiasis Therapy

Antibacterial and Antioxidant Properties of Some Plant Extracts With Propolis

Development of gel containing Psidium glaziovianum essential oil has in vitro antimicrobial activity and improves healing of excisional wounds in mice

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