Antimicrobial and cytotoxic secondary metabolites from tropical leaf endophytes: Isolation of antibacterial agent pyrrocidine C from Lewia infectoria SNB-GTC2402

Casella, Thiago M.; Éparvier, Véronique; Mandavid, Hugues; Bendelac, Audrey; Odonne, Guillaume; Dayan, Laura; Duplais, Christophe; Espindola, Laïla Salmen; Stien, Didier

doi:10.1016/j.phytochem.2013.10.004

Cited by 84 publications

(55 citation statements)

References 26 publications

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“…The general procedures adopted for isolation and identification of the endophytic microorganisms followed the methodology described by Casella et al . Thirty‐eight fungal strains were isolated from D .…”

Section: Methodsmentioning

confidence: 99%

Betulinic Acid, The First Lupane‐Type Triterpenoid Isolated from Both a Phomopsis sp. and Its Host Plant Diospyros carbonaria Benoist

Peyrat

Éparvier

Eydoux

et al. 2016

Chemistry & Biodiversity

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Following a biological screening using a dengue replicon virus-cell-based assay, Diospyros carbonaria AcOEt extract was investigated, affording six known lupane-type triterpenoids endowed with anti-DENV-2 NS5 polymerase activity. The study of the associated microbial community of this species permitted us to identify 38 endophytes belonging to five different orders. Nine out of these 38 strains showed significant activity on the dengue replicon assay. The chemical investigation of the most active one, Phomopsis sp. SNB-LAP1-7-32, led to the isolation of betulinic acid, an anti-viral secondary metabolite isolated previously from the host plant. This result is the first example of a lupane-type triterpenoid isolated from both an endophyte and its host plant. Its presence in the Phomopsis strain may result from gene transfer and/or specific niche selection.

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Section: Methodsmentioning

confidence: 99%

Betulinic Acid, The First Lupane‐Type Triterpenoid Isolated from Both a Phomopsis sp. and Its Host Plant Diospyros carbonaria Benoist

Peyrat

Éparvier

Eydoux

et al. 2016

Chemistry & Biodiversity

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“…To isolate endophytes from the close vicinity of their hosts was a successful strategy in the identification of (novel) organisms with high antimicrobial potential and in many cases new compounds could be isolated and characterized (e.g. Casella et al 2013). However, there are also studies that report antimicrobial effects without further identification of the active principle in extracts of endophytes (e.g.…”

Section: Endophytes Produce Bioactive Compoundsmentioning

confidence: 99%

“…Therefore, the potential of endophytes to synthesize secondary metabolites and to use them in biotechnology has been recognized (e.g. Casella et al 2013). There are already several recent reviews touching the ability of endophytes to produce plant metabolites (Aly et al 2013;Kusari et al 2013;Gandhi et al 2015).…”

Section: Introductionmentioning

confidence: 99%

Plants and endophytes: equal partners in secondary metabolite production?

2015

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Well known plant production systems should be re-evaluated due to findings that the interesting metabolite might actually be produced by microbes intimately associated with the plant, so-called endophytes. Endophytes can be bacteria or fungi and they are characterized usually by the feature that they do not cause any harm to the host. Indeed, in some cases, such as mycorrhizal fungi or other growth promoting endophytes, they can be beneficial for the plant. Here some examples are reviewed where the host plant and/or endophyte metabolism can be induced by the other partner. Also, partial or complete biosynthesis pathways for plant secondary metabolites can be attributed to such endophytes. In other cases the host plant is able to metabolize substances from fungal origin. The question of the natural role of such metabolic changes for the endophyte will be briefly touched. Finally, the consequences for the use of plant cultures for secondary metabolite production is discussed.

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“…SNB-GTC2501, which was isolated from the leaves of Bisboecklera microcephala, exhibited significant antibacterial activity against Staphylococcus aureus (MIC = 8 lg ml À1 ). 12 Chemical investigation of the antibacterial EtOAc extract derived from a solid culture of the Xylaria sp. strain led to the isolation of three known compounds including (À)-5-methylmellein (3), 13 mellein-5-carboxylic acid (4) 14 and ergosterol peroxide (5) 15 along with two unknown compounds (1 and 2).…”

Section: Introductionmentioning

confidence: 99%

Two new isopimarane diterpenoids from the endophytic fungus Xylaria sp. SNB-GTC2501

Sorres

Nirma

Touré

et al. 2015

Tetrahedron Letters

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Antimicrobial and cytotoxic secondary metabolites from tropical leaf endophytes: Isolation of antibacterial agent pyrrocidine C from Lewia infectoria SNB-GTC2402

Cited by 84 publications

References 26 publications

Betulinic Acid, The First Lupane‐Type Triterpenoid Isolated from Both a Phomopsis sp. and Its Host Plant Diospyros carbonaria Benoist

Betulinic Acid, The First Lupane‐Type Triterpenoid Isolated from Both a Phomopsis sp. and Its Host Plant Diospyros carbonaria Benoist

Plants and endophytes: equal partners in secondary metabolite production?

Two new isopimarane diterpenoids from the endophytic fungus Xylaria sp. SNB-GTC2501

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