Antimicrobial and Cytotoxic Activity of Withania somnifera

Atta, Waham S.; Al-Ani, Nabeel K.

doi:10.22401/jnus.18.3.16

Cited by 3 publications

(2 citation statements)

References 10 publications

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“…Some authors reported cytotoxic activity of the adaptogens toward cell lines [ 47 , 48 ]. It has been reported that the silver nanoparticles of the Eleutherococcus senticosus dried stem parts demonstrated substantial cytotoxic and apoptotic effects on A549 lung cancer cells and HT29 colon cancer cells at a concentration of 10 μg/mL.…”

Section: Resultsmentioning

confidence: 99%

Phenolic Profile, Antioxidant, Anti-Enzymatic and Cytotoxic Activity of the Fruits and Roots of Eleutherococcus senticosus (Rupr. et Maxim.) Maxim

et al. 2022

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Eleutherococcus senticosus (Rupr. et Maxim.) Maxim. is well-known for its adaptogenic properties in traditional Eastern medicine. It has been categorized as an endangered species due to the over-exploitation of the roots. As a result, alternatives must be found, including the usage of renewable aerial parts such as fruits. The goal of this research was to determine the phenolic compounds and the enzymatic, antioxidant, and cytotoxic activities of the intractum gained from the E. senticosus fruits and the mixture of chloroform-methanol roots extract with naringenin (3:7:5). The obtained results showed, that the intractum contained 1.02 mg/g ext. of polyphenols, 0.30 mg/g ext. of flavonoids, and 0.19 mg/g ext. of phenolic acids. In turn, the mixture of chloroform-methanol roots extract with naringenin (3:7:5) contained 159.27 mg/g ext. of polyphenols, 137.47 mg/g ext. of flavonoids, and 79.99 mg/g ext. of phenolic acids. Regarding the anti-enzymatic assay, the IC50 values for tyrosinase and hyaluronidase were equal to 586.83 and 217.44 [μg/mL] for the intractum, and 162.56 and 44.80 [μg/mL] for the mixture, respectively. Both preparations have possessed significant antioxidant activity in the ABTS, DPPH, and ferrozine tests. No cytotoxic effect on the FaDu and HEP G2 cancer cell lines was observed. Our findings support the traditional use of fruits and roots. Moreover, the results indicate also that adaptogens are rather nontoxic for normal and cancer cells, which corresponds with some hypotheses on adaptogens activity.

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Section: Resultsmentioning

confidence: 99%

Phenolic Profile, Antioxidant, Anti-Enzymatic and Cytotoxic Activity of the Fruits and Roots of Eleutherococcus senticosus (Rupr. et Maxim.) Maxim

et al. 2022

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“…It is an evergreen shrub, also known as winter cherry and Ashwagandha, has been an important property as herbal medicine [6]. W. somnifera is used in medicine, for antimicrobial activity, anti-fungal, antioxidant, anti-inflammatory, anticancer and other different diseases [7].The roots of W.somnifera contain different type of alkaloids, flavonoids, anolides, reducing sugars, amino acids, steroids, volatile oil, starch, glycosides, hentriacontane, dulcitol and withaniol [8][9]. So the aim is to study the effect of Withania somnifera roots extract on hyperlipidemia in male rabbits.…”

Section: Introductionmentioning

confidence: 99%

Alcoholic extract effect of Withania somnifera roots on cholesterol diet induced hyperlipidemia in male rabbits

Saleh¹,

Laylani

2018

ijs

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The current study was used 20 male rabbits that divided into four groups (consist of five rabbits in each group), The first group was considered as control and fed normal diet and given tap water, The second group was consisted of rabbits that fed on high cholesterol diet for six weeks, The third group was consisted of rabbits that fed on high cholesterol diet and 50mg root extract for six weeks, The forth group was consisted of rabbits that fed on high cholesterol diet and 100mg root extract for six weeks. The male rabbits that feeding on high cholesterol diet showed significant increased (P < 0.05) the levels of cholesterol, triglyceride, LDL, VLDL, MDA and HMG-CoA reductase while HDL and GSH levels were significantly decreased (P < 0.05) compared with to control group. It was concluded from this study that root extract has amply good effective role on hyperlipidemia of male rabbits. Keywords

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The intractum from the Eleutherococcus senticosus fruits affects the innate immunity in human leukocytes: From the ethnomedicinal use to contemporary evidence-based research

Graczyk

Orzechowska

Franz

et al. 2021

Journal of Ethnopharmacology

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Antimicrobial and Cytotoxic Activity of Withania somnifera

Cited by 3 publications

References 10 publications

Phenolic Profile, Antioxidant, Anti-Enzymatic and Cytotoxic Activity of the Fruits and Roots of Eleutherococcus senticosus (Rupr. et Maxim.) Maxim

Phenolic Profile, Antioxidant, Anti-Enzymatic and Cytotoxic Activity of the Fruits and Roots of Eleutherococcus senticosus (Rupr. et Maxim.) Maxim

Alcoholic extract effect of Withania somnifera roots on cholesterol diet induced hyperlipidemia in male rabbits

The intractum from the Eleutherococcus senticosus fruits affects the innate immunity in human leukocytes: From the ethnomedicinal use to contemporary evidence-based research

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