Antimicrobial and cytotoxic activities of Malaysian endophytes

Abstract

Endophytes, which are receiving increasing attention, have been found to be potential sources of bioactive metabolites following the discovery of paclitaxel producing endophytic fungi. In the present study, a total of 348 endophytes were isolated from different parts of 24 Malaysian medicinal plants. Three selected endophytes (HAB10R12, HAB11R3 and HAB21F25) were investigated for their antimicrobial and cytotoxic activities. For antimicrobial activity, HAB10R12 and HAB11R3 were found to be most active against bacteria and fungi, respectively. Their antimicrobial effects were comparable to, if not better than, a number of current commercial antibacterial and antifungal agents. Both HAB10R12 and HAB21F25 were found to be potential anticancer drug candidates, having potent activity against MCF-7 and HCT116 cell lines and warrant further investigation.

Isolation and Identification of Three Bioactive Compounds from Endophytic Fungus Trichoderma sp.

“…The MIC and MBC are shown in Table (1). Since our study was the primary screening for the antibacterial activity of these extracts, assaying MIC is suggested in order to strengthen the findings of the current study [23].Varied values of MIC and MBC were obtained, the reason for this is due to the difference in the cell wall of gram negative bacteria and gram positive bacteria as it is characterized by a wall of negative bacteria lack the permeability of the outer shell of antibiotics because of the presence of the outer layer, which prevents the arrival of antibiotics to the target zone. The wall of gram negative bacteria contains on lipopolysaccharides and lipoprotein and the walls of gram positive bacteria are characterized by permeability for effective compounds more than gram negative bacteria [24].…”

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“…82 , Ginkgo biloba L. 83 (Figure 2) 90 . Two endophytic fungal strains, HAB10R12 and HAB11R3, isolated from Malaysian medicinal plants had potent inhibitory effects on bacterial and fungal pathogens, which were comparable to a number of current commercial antibacterial and antifungal agents 91 .…”

Endophytic pyrones Aspergillus sp. display anti-proliferative effect on several cancer cell lines

“…Currently, there are limited amount of data on endophyte that have been reported. Nevertheless, this is a comparative study in order to compare the activities of the extract with the previous research [8].…”