Antimicrobial and antioxidant activity of propolis from Croatia and Brazil: a comparative study

Kosalec, Ivan; Sanković, Krešimir; Zovko, Marijana; Oršolić, Nada; Bakmaz, Marina; Kalogjera, Z.; Pepeljnjak, Stjepan

doi:10.1055/s-2007-986946

Cited by 19 publications

(36 citation statements)

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“…It estimates the ability of a substance, or an extract which contains it, to donate a proton, and thus cause the transformation of free radicals into a less reactive species. Interestingly, some previous findings indicated that ethanolic propolis extracts were superior reducers and inhibitors of β-carotene degradation [14]. In this study, however, WSDP was more successful inhibitor of β-carotene bleaching than EEP, while the reducing powers of the two extracts were equal.…”

Section: Discussioncontrasting

confidence: 56%

“…This is in accordance with some previous studies which showed a superior activity of ethanolic extract over aqueous in this assay. For example, antiradical activity of ethanolic extracts of both, poplar-type propolis from Croatia and alecrim-type Brazilian propolis, was greater than the activity of their aqueous extracts [14]. …”

Section: Discussionmentioning

confidence: 99%

“…Complexity and variety of the chemical composition of propolis has been reported in the literature. From different botanical and geographical origins of world, more than 300 compounds including volatile organic compounds, flavonoid aglycones, phenolic acids and their esters, phenolic aldehydes, alcohols and ketones, sesquiterpenes, quinones, coumarins, steroids, aminoacids were reported to have been isolated from propolis [12-14]. The main types of flavonoids are galangin, chrisin, pinocebrin and caffeic acid phenethyl ester [13-15].…”

Section: Introductionmentioning

confidence: 99%

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Effect of Croatian propolis on diabetic nephropathy and liver toxicity in mice

Oršolić

Sirovina

Končić

et al. 2012

BMC Complement Altern Med

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BackgroundIn the present study, we examined the antioxidant effect of water soluble derivative of propolis (WSDP) and ethanolic (EEP) extract of propolis on renal and liver function in alloxan-induced diabetic mice. In addition, we examined whether different extract of propolis could prevent diabetic nephropathy and liver toxicity by inhibiting lipid peroxidation in vivo.MethodsDiabetes was induced in Swiss albino mice with a single intravenous injection of alloxan (75 mg kg-1). Two days after alloxan injection, propolis preparations (50 mg kg-1 per day) were given intraperitoneally for 7 days in diabetic mice. Survival analysis and body weights as well as hematological and biochemical parameters were measured. The renal and liver oxidative stress marker malonaldehyde levels and histopathological changes were monitored in the liver and kidney of treated and control mice.ResultsAdministration of propolis to diabetic mice resulted in a significant increase of body weight, haematological and immunological parameters of blood as well as 100% survival of diabetic mice. Alloxan-injected mice showed a marked increase in oxidative stress in liver and kidney homogenate, as determined by lipid peroxidation. Histopathological observation of the liver sections of alloxan-induced diabetic mice showed several lesions including cellular vacuolization, cytoplasmic eosinophilia and lymphocyte infiltrations, but with individual variability.Treatment of diabetic mice with propolis extracts results in decreased number of vacuolized cells and degree of vacuolization; propolis treatment improve the impairment of fatty acid metabolism in diabetes. Renal histology showed corpuscular, tubular and interstitial changes in alloxan-induced diabetic mice. Test components did not improve renal histopathology in diabetic mice.ConclusionsPropolis preparations are able to attenuate diabetic hepatorenal damage, probably through its anti-oxidative action and its detoxification proccess as well as the potential to minimize the deleterious effects of free radicals on tissue. The protective role of propolis against the ROS induced damages in diabetic mice gives a hope that they may have similar protective action in humans.

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Section: Discussioncontrasting

confidence: 56%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Effect of Croatian propolis on diabetic nephropathy and liver toxicity in mice

Oršolić

Sirovina

Končić

et al. 2012

BMC Complement Altern Med

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“…The results are presented as MIC values (Table 1), except for e. coli since no antibacterial activity could be detected and all MIC values were above 50 mg/ml. Nina et al (2015) described limited activity of propolis samples from Argentina against e. coli, while others (Boyanova et al 2006;Kosalec et al 2007) found no inhibitory activity of Bulgarian and Brazilian propolis, respectively, against e. coli. Kosalec et al (2007) found MIC values of below 10.4 mg/ml against e. coli while testing Croatian propolis samples.…”

Section: Discussionmentioning

confidence: 99%

“…Nina et al (2015) described limited activity of propolis samples from Argentina against e. coli, while others (Boyanova et al 2006;Kosalec et al 2007) found no inhibitory activity of Bulgarian and Brazilian propolis, respectively, against e. coli. Kosalec et al (2007) found MIC values of below 10.4 mg/ml against e. coli while testing Croatian propolis samples. On the other hand, it has been shown that Brazilian and Korean propolis inhibit the Gram-negative bacterium s. typhimurium, but have no activity against P. aeruginosa (Choi et al 2006).…”

Section: Discussionmentioning

confidence: 99%

Components responsible for antimicrobial activity of propolis from continental and Mediterranean regions in Croatian

Gajger¹,

Pavlović²,

Bojić³

et al. 2017

Czech J. Food Sci.

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Tlak Gajger I., Pavlović I., Bojić M., Kosalec I., Srečec S., Vlainić T., Vlainić J. Propolis is a popular subject of research worldwide due to its therapeutic potential. The antimicrobial activity of propolis appears to be promising but depends on many variables related to its origin such as the content of phenolics and flavonoids. To address this issue with Croatian propolis, which has two major origins (Mediterranean and continental), we exposed bacteria (escherichia coli and staphylococcus aureus) and yeasts (candida albicans and Aspergillus niger) to different propolis concentrations (two-fold microdilution method with TCC/formazan endpoint). Total phenolic and flavonoid content and chromatographic profile along with antioxidant activity were assessed. The majority of the 24 propolis samples tested exhibited potent antimicrobial activity against s. aureus bacteria and the yeast c. albicans. Most propolis samples also exhibited robust antioxidative capacity which correlated polyphenol and flavonoid content. To the best of our knowledge this is the first study in which the antimicrobial activity of Croatian propolis is correlated with its constituents.

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